Reviewed, UniProtKB/Swiss-Prot Q54IA7 (HEM6_DICDI)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen-III oxidase
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
    EC=1.3.3.3

Gene names

Name:	cpox
Synonyms:	hemF
ORF Names:	DDB_G0288893

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
Sequence similarities	Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Coproporphyrinogen-III oxidase		PRO_0000328892

Sequences

	Sequence		Length	Mass (Da)
	Q54IA7-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: E265FBDFDED984F2	FASTA	332	38,266
	10 20 30 40 50 60 MTSTNEPIPT EEEIKNGFKF IQDEICKFLI TTTGGHQQYS EDKWDYTKGS GGGISRVWEG 70 80 90 100 110 120 KEEEGFYLNQ DYQSQNNKCD KIEKGGVNFS YIVGSNLPSA AATQFKIAPD TKYIATGVSL 130 140 150 160 170 180 VIHPYNPNVP TIHMNVRYFE AGDVWWFGGG VDLTPVYPKL DQVVEFHSTL KKVCDQYGQE 190 200 210 220 230 240 ENKTSYALGK AECDSYFFLP HRGETRGVGG LFFDHLKSDK AKTWKFIYQL GLSFIDLYKP 250 260 270 280 290 300 FLVNNSSISY DKVQREYQLY RRSRYVEFNL LFDRGTKFGI LSEGRTESIL MSLPAVCKWK 310 320 330 YNYKPEENTP EANLLTFLRP RDWLNENQEN KN

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000126 Genomic DNA. Translation: EAL62970.1.
RefSeq	XP_636472.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3388047.
KEGG	ddi:DDB_0231414.
Organism-specific databases
dictyBase	DDB_G0288893. cpox.
Phylogenomic databases
OMA	Q54IA7. INPREWI.
Enzyme and pathway databases
BRENDA	1.3.3.3. 424.
Family and domain databases
InterPro	IPR001260. Coprogen_oxidas. IPR018375. Coproporphyrinogen-3_ox_CS. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_DICDI

Accession

Primary (citable) accession number: Q54IA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)