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Reviewed, UniProtKB/Swiss-Prot Q54IA7 (HEM6_DICDI)

Last modified February 9, 2010. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Coproporphyrinogen-III oxidase
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
    EC=1.3.3.3
Gene names
Name: cpox
Synonyms: hemF
ORF Names: DDB_G0288893
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity.

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Coproporphyrinogen-III oxidase
PRO_0000328892

Regions

Region57 – 8428Important for dimerization By similarity
Region135 – 1373Substrate binding By similarity
Region265 – 30036Important for dimerization By similarity
Region283 – 2886Substrate binding By similarity

Sites

Active site1331Proton donor By similarity
Binding site1191Substrate By similarity
Site2011Important for dimerization By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54IA7-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: E265FBDFDED984F2

FASTA33238,266
        10         20         30         40         50         60 
MTSTNEPIPT EEEIKNGFKF IQDEICKFLI TTTGGHQQYS EDKWDYTKGS GGGISRVWEG 

        70         80         90        100        110        120 
KEEEGFYLNQ DYQSQNNKCD KIEKGGVNFS YIVGSNLPSA AATQFKIAPD TKYIATGVSL 

       130        140        150        160        170        180 
VIHPYNPNVP TIHMNVRYFE AGDVWWFGGG VDLTPVYPKL DQVVEFHSTL KKVCDQYGQE 

       190        200        210        220        230        240 
ENKTSYALGK AECDSYFFLP HRGETRGVGG LFFDHLKSDK AKTWKFIYQL GLSFIDLYKP 

       250        260        270        280        290        300 
FLVNNSSISY DKVQREYQLY RRSRYVEFNL LFDRGTKFGI LSEGRTESIL MSLPAVCKWK 

       310        320        330 
YNYKPEENTP EANLLTFLRP RDWLNENQEN KN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000126 Genomic DNA. Translation: EAL62970.1.
RefSeqXP_636472.1.

3D structure databases

HSSPHSSP built from PDB template 1TK1 based on UniProtKB P11353.
SMRQ54IA7. Positions 11-324.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ54IA7.

Genome annotation databases

GeneID8626855.
KEGGddi:DDB_0231414.

Organism-specific databases

dictyBaseDDB_G0288893. cpox.

Phylogenomic databases

eggNOGKOG1518.
HOGENOMHBG631180.
OMAINPREWI.
PhylomeDBQ54IA7.

Enzyme and pathway databases

BRENDA1.3.3.3. 424.

Family and domain databases

InterProIPR001260. Coprogen_oxidas.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
PROSITEPS01021. COPROGEN_OXIDASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_DICDI
AccessionPrimary (citable) accession number: Q54IA7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents