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Protein

Probable cycloartenol-C-24-methyltransferase 1

Gene

smt1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi: sterol biosynthesis

This protein is involved in the pathway sterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway sterol biosynthesis and in Steroid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • hyperosmotic response Source: dictyBase
  • methylation Source: GO_Central
  • response to bacterium Source: dictyBase
  • sterol biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00766

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cycloartenol-C-24-methyltransferase 1 (EC:2.1.1.41)
Alternative name(s):
24-sterol C-methyltransferase 1
Sterol 24-C-methyltransferase 1
Gene namesi
Name:smt1
ORF Names:DDB_G0288907
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288907 smtA

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003282811 – 354Probable cycloartenol-C-24-methyltransferase 1Add BLAST354

Proteomic databases

PaxDbiQ54I98

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237965

Structurei

3D structure databases

ProteinModelPortaliQ54I98
SMRiQ54I98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1269 Eukaryota
ENOG410XP5G LUCA
InParanoidiQ54I98
KOiK00559
OMAiGIPKMYK
PhylomeDBiQ54I98

Family and domain databases

InterProiView protein in InterPro
IPR013216 Methyltransf_11
IPR030384 MeTrfase_SMT
IPR029063 SAM-dependent_MTases
IPR013705 Sterol_MeTrfase_C
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
PF08498 Sterol_MT_C, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51685 SAM_MT_ERG6_SMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q54I98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTQQRAMEG DLSRIVAISR KEKDAVSRND KVDDTLNGYK ELFKGNDDKA
60 70 80 90 100
IQARKNNYTH MVNTFYDLAT DFYEFGWGQS FHFATRHKYE SFEASIARHE
110 120 130 140 150
MYMAHQLGLF PGMKVIDIGC GVGGPMRTIA RFSGANVVGL NNNEYQIQRG
160 170 180 190 200
KRLNESAGLS HLCSFIKADF MHVPVEDNTY DCAYQIEATC HAPDLVGLYK
210 220 230 240 250
EVFRIVKPGG LFGGYEWIMT NKFNPEDPVE VNIKKQIELG NGLPDLVKPA
260 270 280 290 300
EIINAAKAAG FEVITAFDVA ETSELPWYLP LSSGVSITGF LHTGVGRYLT
310 320 330 340 350
GKFTQLLEIV KLAPAGSYNT NVWLQNAATF LVQGGEKQIF SPMFFLLCRK

PSTD
Length:354
Mass (Da):39,559
Last modified:May 24, 2005 - v1
Checksum:iE5E6C3B08A002B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000126 Genomic DNA Translation: EAL62977.1
RefSeqiXP_636481.1, XM_631389.1

Genome annotation databases

EnsemblProtistsiEAL62977; EAL62977; DDB_G0288907
GeneIDi8626864
KEGGiddi:DDB_G0288907

Similar proteinsi

Entry informationi

Entry nameiSMT1_DICDI
AccessioniPrimary (citable) accession number: Q54I98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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