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Q54I90

- NDUV1_DICDI

UniProt

Q54I90 - NDUV1_DICDI

Protein

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Gene

ndufv1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 FMN.Curated
    Binds 1 4Fe-4S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi396 – 3961Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi399 – 3991Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi402 – 4021Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi442 – 4421Iron-sulfur (4Fe-4S)Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi103 – 11210NAD(H)By similarity
    Nucleotide bindingi216 – 26449FMNBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. FMN binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. NAD binding Source: InterPro
    5. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-51kD
    Short name:
    CI-51kD
    NADH-ubiquinone oxidoreductase 51 kDa subunit
    Gene namesi
    Name:ndufv1
    Synonyms:qinA, rcdG, veg107
    ORF Names:DDB_G0288875
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0288875. ndufv1.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex I Source: UniProtKB
    3. mitochondrion Source: dictyBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 479NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialPRO_0000327999
    Transit peptidei1 – ?Mitochondrion

    Proteomic databases

    PRIDEiQ54I90.

    Interactioni

    Subunit structurei

    Complex I is composed of about 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0191420.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54I90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 51 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1894.
    KOiK03942.
    OMAiKWSFMNP.
    PhylomeDBiQ54I90.

    Family and domain databases

    InterProiIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
    IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
    IPR011537. NADH-UbQ_OxRdtase_suF.
    IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
    IPR019554. Soluble_ligand-bd.
    [Graphical view]
    PfamiPF01512. Complex1_51K. 1 hit.
    PF10589. NADH_4Fe-4S. 1 hit.
    PF10531. SLBB. 1 hit.
    [Graphical view]
    SMARTiSM00928. NADH_4Fe-4S. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
    PROSITEiPS00644. COMPLEX1_51K_1. 1 hit.
    PS00645. COMPLEX1_51K_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54I90-1 [UniParc]FASTAAdd to Basket

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    MMNLGNRVKS VIKLTSTTGL TGKDFQATKV ATFSTAQVQQ AQENVRSYGG    50
    LKDKDRIFTN LYGEHDVYLK GAIARGDWYK TKNIIDKGKD WILKEMMASG 100
    LRGRGGAGFP SGLKWSFMPK TTSKDRPQYL VINADEGEPG TCKDREIMRH 150
    DPHKLIEGCL LAGFAMRACA AYIYIRGEFH YEAKVLEQAI DEAYKAGLIG 200
    ENACGTGYKF DVYVHRGAGA YICGEETALI ESIEGKQGKP RLKPPFPAMA 250
    GLYGCPTTVT NVETVAVAPT ILRRGGAWFA SFGRPKNAGT KLFCISGHVN 300
    NPCTVEEEMS IPLRELIDKH CGGVIGGWDN LKGVIPGGSS VPVLPKNICD 350
    NVLMDFDDLR QHRSGLGTAA VIVMNKETDM IAAIARLSKF YKHESCGQCT 400
    PCREGVGWLY DITDRLVTGN AKPDEIDSLE EISRQIEGHT ICALGDAAAW 450
    PVQGLIRHFR PEIEDRIKQF QLNKKQSPF 479
    Length:479
    Mass (Da):52,691
    Last modified:May 24, 2005 - v1
    Checksum:i1316E7409080C448
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241D → N in AAB03672. (PubMed:8643615)Curated
    Sequence conflicti120 – 1201K → E in AAB03672. (PubMed:8643615)Curated
    Sequence conflicti231 – 2311E → G in AAB03672. (PubMed:8643615)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61989 mRNA. Translation: AAB03672.1.
    AAFI02000126 Genomic DNA. Translation: EAL62961.1.
    RefSeqiXP_636489.1. XM_631397.1.

    Genome annotation databases

    EnsemblProtistsiDDB0191420; DDB0191420; DDB_G0288875.
    GeneIDi8626872.
    KEGGiddi:DDB_G0288875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61989 mRNA. Translation: AAB03672.1 .
    AAFI02000126 Genomic DNA. Translation: EAL62961.1 .
    RefSeqi XP_636489.1. XM_631397.1.

    3D structure databases

    ProteinModelPortali Q54I90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0191420.

    Proteomic databases

    PRIDEi Q54I90.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0191420 ; DDB0191420 ; DDB_G0288875 .
    GeneIDi 8626872.
    KEGGi ddi:DDB_G0288875.

    Organism-specific databases

    dictyBasei DDB_G0288875. ndufv1.

    Phylogenomic databases

    eggNOGi COG1894.
    KOi K03942.
    OMAi KWSFMNP.
    PhylomeDBi Q54I90.

    Miscellaneous databases

    PROi Q54I90.

    Family and domain databases

    InterProi IPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
    IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
    IPR011537. NADH-UbQ_OxRdtase_suF.
    IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
    IPR019554. Soluble_ligand-bd.
    [Graphical view ]
    Pfami PF01512. Complex1_51K. 1 hit.
    PF10589. NADH_4Fe-4S. 1 hit.
    PF10531. SLBB. 1 hit.
    [Graphical view ]
    SMARTi SM00928. NADH_4Fe-4S. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01959. nuoF_fam. 1 hit.
    PROSITEi PS00644. COMPLEX1_51K_1. 1 hit.
    PS00645. COMPLEX1_51K_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ordered yeast artificial chromosome clones representing the Dictyostelium discoideum genome."
      Kuspa A., Loomis W.F.
      Proc. Natl. Acad. Sci. U.S.A. 93:5562-5566(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiNDUV1_DICDI
    AccessioniPrimary (citable) accession number: Q54I90
    Secondary accession number(s): Q23923
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3