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Q54I90

- NDUV1_DICDI

UniProt

Q54I90 - NDUV1_DICDI

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Protein
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Gene
ndufv1, qinA, rcdG, veg107, DDB_G0288875
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 FMN Reviewed prediction.
Binds 1 4Fe-4S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi396 – 3961Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi399 – 3991Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi402 – 4021Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi442 – 4421Iron-sulfur (4Fe-4S) Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 11210NAD(H) By similarity
Nucleotide bindingi216 – 26449FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. FMN binding Source: InterPro
  3. NAD binding Source: InterPro
  4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  5. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-51kD
Short name:
CI-51kD
NADH-ubiquinone oxidoreductase 51 kDa subunit
Gene namesi
Name:ndufv1
Synonyms:qinA, rcdG, veg107
ORF Names:DDB_G0288875
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288875. ndufv1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB
  2. mitochondrial respiratory chain complex I Source: UniProtKB
  3. mitochondrion Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 479NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialPRO_0000327999
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PRIDEiQ54I90.

Interactioni

Subunit structurei

Complex I is composed of about 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0191420.

Structurei

3D structure databases

ProteinModelPortaliQ54I90.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1894.
KOiK03942.
OMAiKWSFMNP.
PhylomeDBiQ54I90.

Family and domain databases

InterProiIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamiPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTiSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
PROSITEiPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54I90-1 [UniParc]FASTAAdd to Basket

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MMNLGNRVKS VIKLTSTTGL TGKDFQATKV ATFSTAQVQQ AQENVRSYGG    50
LKDKDRIFTN LYGEHDVYLK GAIARGDWYK TKNIIDKGKD WILKEMMASG 100
LRGRGGAGFP SGLKWSFMPK TTSKDRPQYL VINADEGEPG TCKDREIMRH 150
DPHKLIEGCL LAGFAMRACA AYIYIRGEFH YEAKVLEQAI DEAYKAGLIG 200
ENACGTGYKF DVYVHRGAGA YICGEETALI ESIEGKQGKP RLKPPFPAMA 250
GLYGCPTTVT NVETVAVAPT ILRRGGAWFA SFGRPKNAGT KLFCISGHVN 300
NPCTVEEEMS IPLRELIDKH CGGVIGGWDN LKGVIPGGSS VPVLPKNICD 350
NVLMDFDDLR QHRSGLGTAA VIVMNKETDM IAAIARLSKF YKHESCGQCT 400
PCREGVGWLY DITDRLVTGN AKPDEIDSLE EISRQIEGHT ICALGDAAAW 450
PVQGLIRHFR PEIEDRIKQF QLNKKQSPF 479
Length:479
Mass (Da):52,691
Last modified:May 24, 2005 - v1
Checksum:i1316E7409080C448
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241D → N in AAB03672. 1 Publication
Sequence conflicti120 – 1201K → E in AAB03672. 1 Publication
Sequence conflicti231 – 2311E → G in AAB03672. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61989 mRNA. Translation: AAB03672.1.
AAFI02000126 Genomic DNA. Translation: EAL62961.1.
RefSeqiXP_636489.1. XM_631397.1.

Genome annotation databases

EnsemblProtistsiDDB0191420; DDB0191420; DDB_G0288875.
GeneIDi8626872.
KEGGiddi:DDB_G0288875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61989 mRNA. Translation: AAB03672.1 .
AAFI02000126 Genomic DNA. Translation: EAL62961.1 .
RefSeqi XP_636489.1. XM_631397.1.

3D structure databases

ProteinModelPortali Q54I90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0191420.

Proteomic databases

PRIDEi Q54I90.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0191420 ; DDB0191420 ; DDB_G0288875 .
GeneIDi 8626872.
KEGGi ddi:DDB_G0288875.

Organism-specific databases

dictyBasei DDB_G0288875. ndufv1.

Phylogenomic databases

eggNOGi COG1894.
KOi K03942.
OMAi KWSFMNP.
PhylomeDBi Q54I90.

Miscellaneous databases

PROi Q54I90.

Family and domain databases

InterProi IPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view ]
Pfami PF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view ]
SMARTi SM00928. NADH_4Fe-4S. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01959. nuoF_fam. 1 hit.
PROSITEi PS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ordered yeast artificial chromosome clones representing the Dictyostelium discoideum genome."
    Kuspa A., Loomis W.F.
    Proc. Natl. Acad. Sci. U.S.A. 93:5562-5566(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiNDUV1_DICDI
AccessioniPrimary (citable) accession number: Q54I90
Secondary accession number(s): Q23923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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