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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Gene

ndufv1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Protein has several cofactor binding sites:
  • FMNCuratedNote: Binds 1 FMN.Curated
  • [4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi396Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi399Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi402Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi442Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi103 – 112NAD(H)By similarity10
Nucleotide bindingi216 – 264FMNBy similarityAdd BLAST49

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-DDI-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-51kD
Short name:
CI-51kD
NADH-ubiquinone oxidoreductase 51 kDa subunit
Gene namesi
Name:ndufv1
Synonyms:qinA, rcdG, veg107
ORF Names:DDB_G0288875
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288875 ndufv1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000327999? – 479NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PaxDbiQ54I90

Interactioni

Subunit structurei

Complex I is composed of about 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0191420

Structurei

3D structure databases

ProteinModelPortaliQ54I90
SMRiQ54I90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 51 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2658 Eukaryota
COG1894 LUCA
InParanoidiQ54I90
KOiK03942
OMAiSGMKWSF
PhylomeDBiQ54I90

Family and domain databases

Gene3Di1.20.1440.230, 1 hit
3.40.50.11540, 1 hit
InterProiView protein in InterPro
IPR001949 NADH-UbQ_OxRdtase_51kDa_CS
IPR011537 NADH-UbQ_OxRdtase_suF
IPR011538 Nuo51_FMN-bd
IPR037225 Nuo51_FMN-bd_sf
IPR019575 Nuop51_4Fe4S-bd
IPR037207 Nuop51_4Fe4S-bd_sf
IPR019554 Soluble_ligand-bd
PfamiView protein in Pfam
PF01512 Complex1_51K, 1 hit
PF10589 NADH_4Fe-4S, 1 hit
PF10531 SLBB, 1 hit
SMARTiView protein in SMART
SM00928 NADH_4Fe-4S, 1 hit
SUPFAMiSSF140490 SSF140490, 1 hit
SSF142019 SSF142019, 1 hit
TIGRFAMsiTIGR01959 nuoF_fam, 1 hit
PROSITEiView protein in PROSITE
PS00644 COMPLEX1_51K_1, 1 hit
PS00645 COMPLEX1_51K_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54I90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNLGNRVKS VIKLTSTTGL TGKDFQATKV ATFSTAQVQQ AQENVRSYGG
60 70 80 90 100
LKDKDRIFTN LYGEHDVYLK GAIARGDWYK TKNIIDKGKD WILKEMMASG
110 120 130 140 150
LRGRGGAGFP SGLKWSFMPK TTSKDRPQYL VINADEGEPG TCKDREIMRH
160 170 180 190 200
DPHKLIEGCL LAGFAMRACA AYIYIRGEFH YEAKVLEQAI DEAYKAGLIG
210 220 230 240 250
ENACGTGYKF DVYVHRGAGA YICGEETALI ESIEGKQGKP RLKPPFPAMA
260 270 280 290 300
GLYGCPTTVT NVETVAVAPT ILRRGGAWFA SFGRPKNAGT KLFCISGHVN
310 320 330 340 350
NPCTVEEEMS IPLRELIDKH CGGVIGGWDN LKGVIPGGSS VPVLPKNICD
360 370 380 390 400
NVLMDFDDLR QHRSGLGTAA VIVMNKETDM IAAIARLSKF YKHESCGQCT
410 420 430 440 450
PCREGVGWLY DITDRLVTGN AKPDEIDSLE EISRQIEGHT ICALGDAAAW
460 470
PVQGLIRHFR PEIEDRIKQF QLNKKQSPF
Length:479
Mass (Da):52,691
Last modified:May 24, 2005 - v1
Checksum:i1316E7409080C448
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24D → N in AAB03672 (PubMed:8643615).Curated1
Sequence conflicti120K → E in AAB03672 (PubMed:8643615).Curated1
Sequence conflicti231E → G in AAB03672 (PubMed:8643615).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61989 mRNA Translation: AAB03672.1
AAFI02000126 Genomic DNA Translation: EAL62961.1
RefSeqiXP_636489.1, XM_631397.1

Genome annotation databases

EnsemblProtistsiEAL62961; EAL62961; DDB_G0288875
GeneIDi8626872
KEGGiddi:DDB_G0288875

Similar proteinsi

Entry informationi

Entry nameiNDUV1_DICDI
AccessioniPrimary (citable) accession number: Q54I90
Secondary accession number(s): Q23923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health