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Q54I90 (NDUV1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-51kD
Short name=CI-51kD
NADH-ubiquinone oxidoreductase 51 kDa subunit
Gene names
Name:ndufv1
Synonyms:qinA, rcdG, veg107
ORF Names:DDB_G0288875
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone = NAD+ + ubiquinol.

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 FMN Potential.

Binds 1 4Fe-4S cluster Potential.

Subunit structure

Complex I is composed of about 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 479NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialPRO_0000327999

Regions

Nucleotide binding103 – 11210NAD(H) By similarity
Nucleotide binding216 – 26449FMN By similarity

Sites

Metal binding3961Iron-sulfur (4Fe-4S) Potential
Metal binding3991Iron-sulfur (4Fe-4S) Potential
Metal binding4021Iron-sulfur (4Fe-4S) Potential
Metal binding4421Iron-sulfur (4Fe-4S) Potential

Experimental info

Sequence conflict241D → N in AAB03672. Ref.1
Sequence conflict1201K → E in AAB03672. Ref.1
Sequence conflict2311E → G in AAB03672. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q54I90 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 1316E7409080C448

FASTA47952,691
        10         20         30         40         50         60 
MMNLGNRVKS VIKLTSTTGL TGKDFQATKV ATFSTAQVQQ AQENVRSYGG LKDKDRIFTN 

        70         80         90        100        110        120 
LYGEHDVYLK GAIARGDWYK TKNIIDKGKD WILKEMMASG LRGRGGAGFP SGLKWSFMPK 

       130        140        150        160        170        180 
TTSKDRPQYL VINADEGEPG TCKDREIMRH DPHKLIEGCL LAGFAMRACA AYIYIRGEFH 

       190        200        210        220        230        240 
YEAKVLEQAI DEAYKAGLIG ENACGTGYKF DVYVHRGAGA YICGEETALI ESIEGKQGKP 

       250        260        270        280        290        300 
RLKPPFPAMA GLYGCPTTVT NVETVAVAPT ILRRGGAWFA SFGRPKNAGT KLFCISGHVN 

       310        320        330        340        350        360 
NPCTVEEEMS IPLRELIDKH CGGVIGGWDN LKGVIPGGSS VPVLPKNICD NVLMDFDDLR 

       370        380        390        400        410        420 
QHRSGLGTAA VIVMNKETDM IAAIARLSKF YKHESCGQCT PCREGVGWLY DITDRLVTGN 

       430        440        450        460        470 
AKPDEIDSLE EISRQIEGHT ICALGDAAAW PVQGLIRHFR PEIEDRIKQF QLNKKQSPF

« Hide

References

[1]"Ordered yeast artificial chromosome clones representing the Dictyostelium discoideum genome."
Kuspa A., Loomis W.F.
Proc. Natl. Acad. Sci. U.S.A. 93:5562-5566(1996) [PubMed: 8643615] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U61989 mRNA. Translation: AAB03672.1.
AAFI02000126 Genomic DNA. Translation: EAL62961.1.
RefSeqXP_636489.1. XM_631397.1.

3D structure databases

HSSPHSSP built from PDB template 2FUG based on UniProtKB Q56222.
ProteinModelPortalQ54I90.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ54I90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0191420; DDB0191420; DDB_G0288875.
GeneID8626872.
GenomeReviewsGene locus ndufv1 in contig CM000154_GR.
KEGGddi:DDB_G0288875.

Organism-specific databases

dictyBaseDDB_G0288875. ndufv1.

Phylogenomic databases

eggNOGKOG2658.
GeneTreeEPrGT00050000005855.
HOGENOMHBG669338.
OMAKHAGGVT.
PhylomeDBQ54I90.
ProtClustDBPTZ00304.

Family and domain databases

InterProIPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
KOK03942.
PfamPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]
TIGRFAMsTIGR01959. NuoF_fam. 1 hit.
PROSITEPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUV1_DICDI
AccessionPrimary (citable) accession number: Q54I90
Secondary accession number(s): Q23923
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

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