Q54I82 (CDD_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytidine deaminase
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase

Gene names

Name:	cda
ORF Names:	DDB_G0288933

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxycytidine catabolic process Inferred from sequence or structural similarity. Source: dictyBase pyrimidine-containing compound salvage Inferred from sequence or structural similarity. Source: dictyBase
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: dictyBase nucleus Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	cytidine deaminase activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 147	147	Probable cytidine deaminase		PRO_0000328079
Regions
	Region	45 – 51	7	Substrate binding By similarity
Sites
	Active site	58	1	Proton donor By similarity
	Metal binding	56	1	Zinc; catalytic By similarity
	Metal binding	90	1	Zinc; catalytic By similarity
	Metal binding	93	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54I82 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 09C5F427AB1ADD1F	FASTA	147	16,263
	10 20 30 40 50 60 MNQEELEKCI DAAQNSQQYA HCPYSHFRIG AALLTSCGKI FTGVNVENSS YGLTICAERT 70 80 90 100 110 120 AYTKAVSEGY KSFKGIVVAS DLKDRFITPC GACRQFGVEF GDFEVVCVKP DRSTFKSSTH 130 140 KLLPGLFSQE DLIAKAEQDE RECKAQN

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000126 Genomic DNA. Translation: EAL62990.1.
RefSeq	XP_636497.1. XM_631405.1.
3D structure databases
HSSP	HSSP built from PDB template 1MQ0 based on UniProtKB P32320.
ProteinModelPortal	Q54I82.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54I82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0230205; DDB0230205; DDB_G0288933.
GeneID	8626880.
GenomeReviews	Gene locus cda in contig CM000154_GR.
KEGG	ddi:DDB_G0288933.
Organism-specific databases
dictyBase	DDB_G0288933. cda.
Phylogenomic databases
eggNOG	KOG0833.
HOGENOM	HBG352939.
OMA	EFFEENT.
PhylomeDB	Q54I82.
ProtClustDB	CLSZ2429832.
Family and domain databases
InterPro	IPR002125. CMP_dCMP_Zn-bd. IPR006262. Cyt_deam_tetra. IPR016193. Cytidine_deaminase-like. [Graphical view]
KO	K01489.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view]
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit.
TIGRFAMs	TIGR01354. Cyt_deam_tetra. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_DICDI

Accession

Primary (citable) accession number: Q54I82

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)