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Q54I82

- CDD_DICDI

UniProt

Q54I82 - CDD_DICDI

Protein

Probable cytidine deaminase

Gene

cda

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

    Catalytic activityi

    Cytidine + H2O = uridine + NH3.
    2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi56 – 561Zinc; catalyticBy similarity
    Active sitei58 – 581Proton donorBy similarity
    Metal bindingi90 – 901Zinc; catalyticBy similarity
    Metal bindingi93 – 931Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. cytidine deaminase activity Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cytidine catabolic process Source: dictyBase
    2. cytidine deamination Source: UniProtKB
    3. deoxycytidine catabolic process Source: dictyBase
    4. pyrimidine-containing compound salvage Source: dictyBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytidine deaminase (EC:3.5.4.5)
    Alternative name(s):
    Cytidine aminohydrolase
    Gene namesi
    Name:cda
    ORF Names:DDB_G0288933
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0288933. cda.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: dictyBase
    2. nucleus Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Probable cytidine deaminasePRO_0000328079Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0230205.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54I82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 108105CMP/dCMP deaminase zinc-bindingAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni45 – 517Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    KOiK01489.
    OMAiCAERTAY.
    PhylomeDBiQ54I82.

    Family and domain databases

    InterProiIPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54I82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQEELEKCI DAAQNSQQYA HCPYSHFRIG AALLTSCGKI FTGVNVENSS    50
    YGLTICAERT AYTKAVSEGY KSFKGIVVAS DLKDRFITPC GACRQFGVEF 100
    GDFEVVCVKP DRSTFKSSTH KLLPGLFSQE DLIAKAEQDE RECKAQN 147
    Length:147
    Mass (Da):16,263
    Last modified:May 24, 2005 - v1
    Checksum:i09C5F427AB1ADD1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000126 Genomic DNA. Translation: EAL62990.1.
    RefSeqiXP_636497.1. XM_631405.1.

    Genome annotation databases

    EnsemblProtistsiDDB0230205; DDB0230205; DDB_G0288933.
    GeneIDi8626880.
    KEGGiddi:DDB_G0288933.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000126 Genomic DNA. Translation: EAL62990.1 .
    RefSeqi XP_636497.1. XM_631405.1.

    3D structure databases

    ProteinModelPortali Q54I82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0230205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0230205 ; DDB0230205 ; DDB_G0288933 .
    GeneIDi 8626880.
    KEGGi ddi:DDB_G0288933.

    Organism-specific databases

    dictyBasei DDB_G0288933. cda.

    Phylogenomic databases

    eggNOGi COG0295.
    KOi K01489.
    OMAi CAERTAY.
    PhylomeDBi Q54I82.

    Miscellaneous databases

    PROi Q54I82.

    Family and domain databases

    InterProi IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiCDD_DICDI
    AccessioniPrimary (citable) accession number: Q54I82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3