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Protein

Probable cytidine deaminase

Gene

cda

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Zinc; catalyticBy similarity1
Active sitei58Proton donorBy similarity1
Metal bindingi90Zinc; catalyticBy similarity1
Metal bindingi93Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DDI-6798695. Neutrophil degranulation.
R-DDI-73614. Pyrimidine salvage reactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytidine deaminase (EC:3.5.4.5)
Alternative name(s):
Cytidine aminohydrolase
Gene namesi
Name:cda
ORF Names:DDB_G0288933
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288933. cda.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003280791 – 147Probable cytidine deaminaseAdd BLAST147

Proteomic databases

PaxDbiQ54I82.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0230205.

Structurei

3D structure databases

ProteinModelPortaliQ54I82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 130CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 51Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0833. Eukaryota.
COG0295. LUCA.
InParanoidiQ54I82.
KOiK01489.
OMAiRIFKANQ.
PhylomeDBiQ54I82.

Family and domain databases

InterProiIPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54I82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQEELEKCI DAAQNSQQYA HCPYSHFRIG AALLTSCGKI FTGVNVENSS
60 70 80 90 100
YGLTICAERT AYTKAVSEGY KSFKGIVVAS DLKDRFITPC GACRQFGVEF
110 120 130 140
GDFEVVCVKP DRSTFKSSTH KLLPGLFSQE DLIAKAEQDE RECKAQN
Length:147
Mass (Da):16,263
Last modified:May 24, 2005 - v1
Checksum:i09C5F427AB1ADD1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000126 Genomic DNA. Translation: EAL62990.1.
RefSeqiXP_636497.1. XM_631405.1.

Genome annotation databases

EnsemblProtistsiEAL62990; EAL62990; DDB_G0288933.
GeneIDi8626880.
KEGGiddi:DDB_G0288933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000126 Genomic DNA. Translation: EAL62990.1.
RefSeqiXP_636497.1. XM_631405.1.

3D structure databases

ProteinModelPortaliQ54I82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0230205.

Proteomic databases

PaxDbiQ54I82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL62990; EAL62990; DDB_G0288933.
GeneIDi8626880.
KEGGiddi:DDB_G0288933.

Organism-specific databases

dictyBaseiDDB_G0288933. cda.

Phylogenomic databases

eggNOGiKOG0833. Eukaryota.
COG0295. LUCA.
InParanoidiQ54I82.
KOiK01489.
OMAiRIFKANQ.
PhylomeDBiQ54I82.

Enzyme and pathway databases

ReactomeiR-DDI-6798695. Neutrophil degranulation.
R-DDI-73614. Pyrimidine salvage reactions.

Miscellaneous databases

PROiQ54I82.

Family and domain databases

InterProiIPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDD_DICDI
AccessioniPrimary (citable) accession number: Q54I82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.