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Protein

Pantoate--beta-alanine ligase

Gene

panC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.By similarity

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.By similarity

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Pantoate--beta-alanine ligase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50Proton donorBy similarity1
Binding sitei74Beta-alanineBy similarity1
Binding sitei74PantoateBy similarity1
Binding sitei168PantoateBy similarity1
Binding sitei191ATP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 50ATPBy similarity8
Nucleotide bindingi162 – 165ATPBy similarity4
Nucleotide bindingi199 – 202ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene namesi
Name:panC
ORF Names:DDB_G0288935
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288935 panC

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003280421 – 300Pantoate--beta-alanine ligaseAdd BLAST300

Proteomic databases

PaxDbiQ54I80
PRIDEiQ54I80

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231511

Structurei

3D structure databases

ProteinModelPortaliQ54I80
SMRiQ54I80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.Curated

Phylogenomic databases

eggNOGiKOG3042 Eukaryota
COG0414 LUCA
InParanoidiQ54I80
KOiK01918
OMAiQITKPDN
PhylomeDBiQ54I80

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

Q54I80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELIICNNI KLIKEEIHKK KIEISKRNNK EYYEIKVGFV PTMGYLHSGH
60 70 80 90 100
ISLVERAKLE NDIVVVSIFV NPTQFNANED LSSYPSDIEN DSKLLKNVGT
110 120 130 140 150
DLLFLPTPDI MYPKESGYST FVTVESMEQV MEGKSRPGHF RGVATIVTKL
160 170 180 190 200
LLITTPTNLY IGQKDAMQCI CIKRLVADLN IDTNVIICNT IREDTGLAKS
210 220 230 240 250
SRNSYLSNEE QIQASSIYKI LESFKNNINS FTDRQSFINE ITKQLEQNPL
260 270 280 290 300
FKVEYVSIAS NITGLEIIDQ FPPPKDSNLS LALLFFAEKR KTRLIDIIIL
Length:300
Mass (Da):34,105
Last modified:May 24, 2005 - v1
Checksum:iDE906470A9BDCA46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000126 Genomic DNA Translation: EAL62991.1
RefSeqiXP_636499.1, XM_631407.1

Genome annotation databases

EnsemblProtistsiEAL62991; EAL62991; DDB_G0288935
GeneIDi8626882
KEGGiddi:DDB_G0288935

Similar proteinsi

Entry informationi

Entry nameiPANC_DICDI
AccessioniPrimary (citable) accession number: Q54I80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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