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Q54I80 (PANC_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantoate--beta-alanine ligase

EC=6.3.2.1
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene names
Name:panC
ORF Names:DDB_G0288935
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Sequence similarities

Belongs to the pantothenate synthetase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytosol

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantoate-beta-alanine ligase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
PRO_0000328042

Regions

Nucleotide binding43 – 508ATP By similarity
Nucleotide binding162 – 1654ATP By similarity
Nucleotide binding199 – 2024ATP By similarity

Sites

Active site501Proton donor By similarity
Binding site741Beta-alanine By similarity
Binding site741Pantoate By similarity
Binding site1681Pantoate By similarity
Binding site1911ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54I80 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: DE906470A9BDCA46

FASTA30034,105
        10         20         30         40         50         60 
MKELIICNNI KLIKEEIHKK KIEISKRNNK EYYEIKVGFV PTMGYLHSGH ISLVERAKLE 

        70         80         90        100        110        120 
NDIVVVSIFV NPTQFNANED LSSYPSDIEN DSKLLKNVGT DLLFLPTPDI MYPKESGYST 

       130        140        150        160        170        180 
FVTVESMEQV MEGKSRPGHF RGVATIVTKL LLITTPTNLY IGQKDAMQCI CIKRLVADLN 

       190        200        210        220        230        240 
IDTNVIICNT IREDTGLAKS SRNSYLSNEE QIQASSIYKI LESFKNNINS FTDRQSFINE 

       250        260        270        280        290        300 
ITKQLEQNPL FKVEYVSIAS NITGLEIIDQ FPPPKDSNLS LALLFFAEKR KTRLIDIIIL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000126 Genomic DNA. Translation: EAL62991.1.
RefSeqXP_636499.1. XM_631407.1.

3D structure databases

ProteinModelPortalQ54I80.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231511.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231511; DDB0231511; DDB_G0288935.
GeneID8626882.
KEGGddi:DDB_G0288935.

Organism-specific databases

dictyBaseDDB_G0288935. panC.

Phylogenomic databases

eggNOGCOG0414.
OMAAMQCICI.
PhylomeDBQ54I80.

Enzyme and pathway databases

UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetSearch...

Other

PROQ54I80.

Entry information

Entry namePANC_DICDI
AccessionPrimary (citable) accession number: Q54I80
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase