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Protein

Probable valine--tRNA ligase, mitochondrial

Gene

valS2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei609ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable valine--tRNA ligase, mitochondrial (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:valS2
ORF Names:DDB_G0288939
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288939. valS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000032776121 – 1051Probable valine--tRNA ligase, mitochondrialAdd BLAST1031

Proteomic databases

PaxDbiQ54I78.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0304686.

Structurei

3D structure databases

ProteinModelPortaliQ54I78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili972 – 1019Sequence analysisAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi71 – 81"HIGH" regionBy similarityAdd BLAST11
Motifi606 – 610"KMSKS" regionBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi721 – 725Poly-Asn5
Compositional biasi946 – 958Poly-AsnAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
InParanoidiQ54I78.
KOiK01873.
OMAiILHACMD.
PhylomeDBiQ54I78.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54I78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLLFLSKK SSTSNLYRFY SRAPINESSI KSSFDPKVVE EFKYKYWQDS
60 70 80 90 100
GLFKPKSNNG GEKFSMVLPP PNVTGSLHIG HSLTTTIQDS LIRYNRMMGK
110 120 130 140 150
EVLWVPGLDH SGIATQVAVE KELQVKQGKT RFDLGREKFL EQVFQWTDQY
160 170 180 190 200
SSNINNQLKI TGSSLDWSRS VFTLDEQRND AVQTAFIRMF EMGLIYRSTR
210 220 230 240 250
LVNWCPYLQS VISDIEVDHK VIEKPTMLKL KSRKKSVEVG AIHNIAYMME
260 270 280 290 300
DPMLAPLIVS TTRPETIFGD TGLAIHPLDE RYKDYHGKFA IHPFNHERIP
310 320 330 340 350
IVLDDILVNR EMGTGVVKIT PAHDFNDYQC GQRHSLPIVN ILNSNGTLNE
360 370 380 390 400
NSTAEFEGVD RLDARSMVIE KLEQMGLYRE KLAHPQTLSI CSRSGDLLEP
410 420 430 440 450
VLKPQWYVKC KDMADKSIEF VESGEIKIIP ESFRADWSRW LTNIQDWCIS
460 470 480 490 500
RQLWWGNPIP AYRVIMIDKV TNEDLDIHLT ETERLKQEKW VVGKNEKEAR
510 520 530 540 550
ENVFKTYGIA NAGEYRLEKD QDVLDTWFSS GLFPISSMGW PTATKNSDND
560 570 580 590 600
NDFSRFLPLD VMETGSDILF FWVARMVMMC STLNNGEVPF KTILLHPMIR
610 620 630 640 650
DSQGRKMSKS LGNVIDPLHV INGISLQDLK ENLSKSNLSQ QEKVTATKGL
660 670 680 690 700
EKEFPQGIPQ CGTDSLRFSL AQYPINGKDI NLDISKIIGN RLFCNKLWNA
710 720 730 740 750
SKFVFNYLVN LNNLSINLYY NNNNNEKDQQ QPFNYLESTT LIDKWILLKL
760 770 780 790 800
SKLVEIVNES YKSNNLSIAA QSLYSFFQYD FCDIYIECIK ADLSKPILSK
810 820 830 840 850
QNEHSSLVLA SVLDSYLRML HPFMPFITED LWQRLPKSKQ QLEIANSIEI
860 870 880 890 900
DDSLSIMISD YPNPSYKYHQ LFKNQEIEIE KQVNLFLDTL KLIRSQKVSL
910 920 930 940 950
GINEKTKLII KLQIIGDDQI LIKSSFNQLK DSFEKLLNSN LIIDENNNND
960 970 980 990 1000
NNNNNDNNDL TNISINKFTI SKELQISIEF DKEINNQLNQ KLINPNQSND
1010 1020 1030 1040 1050
KKILKLENFI KQLQDEIDNP DFKQRVPEKV QNIKIEKLNQ YKIELKEIYK

K
Length:1,051
Mass (Da):121,425
Last modified:January 19, 2010 - v2
Checksum:i9631791BD20CB26C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000126 Genomic DNA. Translation: EAL62993.2.
RefSeqiXP_636501.2. XM_631409.2.

Genome annotation databases

EnsemblProtistsiEAL62993; EAL62993; DDB_G0288939.
GeneIDi8626884.
KEGGiddi:DDB_G0288939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000126 Genomic DNA. Translation: EAL62993.2.
RefSeqiXP_636501.2. XM_631409.2.

3D structure databases

ProteinModelPortaliQ54I78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0304686.

Proteomic databases

PaxDbiQ54I78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL62993; EAL62993; DDB_G0288939.
GeneIDi8626884.
KEGGiddi:DDB_G0288939.

Organism-specific databases

dictyBaseiDDB_G0288939. valS2.

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
InParanoidiQ54I78.
KOiK01873.
OMAiILHACMD.
PhylomeDBiQ54I78.

Miscellaneous databases

PROiQ54I78.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYVM_DICDI
AccessioniPrimary (citable) accession number: Q54I78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 19, 2010
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.