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Protein

Ubiquitin-conjugating enzyme E2 S

Gene

ube2s

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 S (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme S
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene namesi
Name:ube2s
ORF Names:DDB_G0289021
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289021 ube2s

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277521 – 215Ubiquitin-conjugating enzyme E2 SAdd BLAST215

Proteomic databases

PaxDbiQ54I43

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0305006

Structurei

3D structure databases

ProteinModelPortaliQ54I43
SMRiQ54I43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 167Poly-Asn6
Compositional biasi169 – 180Poly-ThrAdd BLAST12

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0423 Eukaryota
COG5078 LUCA
InParanoidiQ54I43
KOiK10583
OMAiGHKGEIC
PhylomeDBiQ54I43

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q54I43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSENLPPDV IKRVVKELKE LNSSTLEGIT LLPCEEDITN IEAVVTGPAG
60 70 80 90 100
TPYEGGYFKA RLILSSDFPR SPPKANFITK IFHPNVSKKG EICVNTLKKD
110 120 130 140 150
WTEDLGLKHI LLTIKCLLIV PNAESSLNED ASRLLLENYD DYCKHAKLFT
160 170 180 190 200
SIHASKPIID SNNNNENSTT TPTTTTTATT PSTNTASISS PVKKKTETTN
210
STTTKVQPKK SLKRL
Length:215
Mass (Da):23,617
Last modified:May 24, 2005 - v1
Checksum:i8D79DBBEBAD4519C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000129 Genomic DNA Translation: EAL62926.1
RefSeqiXP_636428.1, XM_631336.1

Genome annotation databases

EnsemblProtistsiEAL62926; EAL62926; DDB_G0289021
GeneIDi8626920
KEGGiddi:DDB_G0289021

Similar proteinsi

Entry informationi

Entry nameiUBE2S_DICDI
AccessioniPrimary (citable) accession number: Q54I43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health