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Protein

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Gene

mmsdh

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).By similarity

Catalytic activityi

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei307 – 3071NucleophilePROSITE-ProRule annotation
Binding sitei408 – 4081NADSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2035NADSequence analysis
Nucleotide bindingi251 – 2566NADSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-DDI-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (EC:1.2.1.18, EC:1.2.1.27)
Short name:
MMSDH
Short name:
Malonate-semialdehyde dehydrogenase [acylating]
Gene namesi
Name:mmsdh
Synonyms:aldh6
ORF Names:DDB_G0289085
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289085. mmsdh.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626MitochondrionSequence analysisAdd
BLAST
Chaini27 – 528502Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialPRO_0000327926Add
BLAST

Proteomic databases

PaxDbiQ54I10.
PRIDEiQ54I10.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231483.

Structurei

3D structure databases

ProteinModelPortaliQ54I10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
InParanoidiQ54I10.
KOiK00140.
OMAiSNVKPNM.
PhylomeDBiQ54I10.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54I10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFKFAKSA SKVIGNRNFH SSSASLANTT KLFINGKFVE SKTKEWLEVR
60 70 80 90 100
NPATQELVTK VPVSTKEEME AAVKAASDAF PAWRDTSVSN RSRIISNYKN
110 120 130 140 150
LINKNMDKIA AIITEEQGKT LPDAKGDVFR GLEVVEHSVN VASLMMGETV
160 170 180 190 200
ENVSKNVDIY SYVQPLGVCA GITPFNFPAM IPLWMFPLAI ACGNTFVLKP
210 220 230 240 250
SERVPSASMF LVQLAQEAGV PDGVVNVIHG GKEAVNFICD APEVRAISFV
260 270 280 290 300
GADQAGRHIH ARGTANGKRV QSNMAAKNHA TIVPDAHKER TLDALTGAAF
310 320 330 340 350
GASGQRCMAL SAAVFVGESK NWIPELAERA KKLKVAGGAA PGADLGPVIS
360 370 380 390 400
AASKQRIHEL IQSGIDEGAK CILDGRNVVV DPEFSKGNFV GPTILTDVKP
410 420 430 440 450
HMRCYKEEIF GPVLVCLNVD TVDQAIQLIN ANPYGNGTAV FTSSGAVARK
460 470 480 490 500
YQREIDVGQV GINLPIPVPL PFFSFTGSRG SFVGAGHFYG KTGVQFFTQI
510 520
KTITSNWRDD DISHGVSSSM NMPILGKN
Length:528
Mass (Da):56,696
Last modified:May 24, 2005 - v1
Checksum:iD83629D894CC3E68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000130 Genomic DNA. Translation: EAL62892.1.
RefSeqiXP_636395.1. XM_631303.1.

Genome annotation databases

EnsemblProtistsiDDB0231483; DDB0231483; DDB_G0289085.
GeneIDi8626954.
KEGGiddi:DDB_G0289085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000130 Genomic DNA. Translation: EAL62892.1.
RefSeqiXP_636395.1. XM_631303.1.

3D structure databases

ProteinModelPortaliQ54I10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231483.

Proteomic databases

PaxDbiQ54I10.
PRIDEiQ54I10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231483; DDB0231483; DDB_G0289085.
GeneIDi8626954.
KEGGiddi:DDB_G0289085.

Organism-specific databases

dictyBaseiDDB_G0289085. mmsdh.

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
InParanoidiQ54I10.
KOiK00140.
OMAiSNVKPNM.
PhylomeDBiQ54I10.

Enzyme and pathway databases

ReactomeiR-DDI-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

PROiQ54I10.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMMSA_DICDI
AccessioniPrimary (citable) accession number: Q54I10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.