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Q54HS3

- SET1_DICDI

UniProt

Q54HS3 - SET1_DICDI

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Protein
Histone-lysine N-methyltransferase set1
Gene
set1, H3K4, DDB_G0289257
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Histone methyltransferase that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. May act to regulate chromatin-mediated events.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K4 specific) Source: dictyBase

GO - Biological processi

  1. aggregation involved in sorocarp development Source: dictyBase
  2. histone H3-K4 methylation Source: GOC
  3. histone methylation Source: dictyBase
  4. regulation of gene expression, epigenetic Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase set1 (EC:2.1.1.43)
Alternative name(s):
Histone H3 lysine 4 methyltransferase
SET domain-containing protein 1
Gene namesi
Name:set1
Synonyms:H3K4
ORF Names:DDB_G0289257
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289257. set1.

Subcellular locationi

Nucleus. Chromosome Inferred 1 Publication

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Cells display unusually rapid development, characterized by precocious aggregation into multicellular aggregates, and completely lack mono-, di- and trimethylation of H3K4 ('Lys-5' of histone 3). Cells also induce premature differentiation.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1425 – 14251N → Q: Loss of catalytic activity; when associated with Ala-1474. 1 Publication
Mutagenesisi1474 – 14741C → A: Loss of catalytic activity; when associated with Gln-1425. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14861486Histone-lysine N-methyltransferase set1
PRO_0000379483Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0233375.

Structurei

3D structure databases

ProteinModelPortaliQ54HS3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1347 – 1464118SET
Add
BLAST
Domaini1470 – 148617Post-SET
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili359 – 40042 Reviewed prediction
Add
BLAST
Coiled coili717 – 74428 Reviewed prediction
Add
BLAST
Coiled coili1177 – 125579 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 4415Poly-Asn
Add
BLAST
Compositional biasi45 – 506Poly-Thr
Compositional biasi116 – 14025Thr-rich
Add
BLAST
Compositional biasi143 – 1486Poly-Asn
Compositional biasi225 – 23713Poly-Thr
Add
BLAST
Compositional biasi321 – 33212Poly-Pro
Add
BLAST
Compositional biasi335 – 3406Poly-Pro
Compositional biasi360 – 39233Poly-Gln
Add
BLAST
Compositional biasi455 – 54288Arg-rich
Add
BLAST
Compositional biasi553 – 58533Thr-rich
Add
BLAST
Compositional biasi619 – 6257Poly-Ser
Compositional biasi627 – 66236Poly-Asn
Add
BLAST
Compositional biasi884 – 8896Poly-Gln
Compositional biasi912 – 9154Poly-Asn
Compositional biasi916 – 93015Poly-Asp
Add
BLAST
Compositional biasi958 – 9625Poly-Asp
Compositional biasi963 – 97917Poly-His
Add
BLAST
Compositional biasi1066 – 107611Poly-Thr
Add
BLAST
Compositional biasi1219 – 12235Poly-Asn
Compositional biasi1295 – 130713Poly-Ser
Add
BLAST

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 SET domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ54HS3.
KOiK11422.
OMAiWERDRDW.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54HS3-1 [UniParc]FASTAAdd to Basket

« Hide

MENETIVDNS LNNKSNVNNS NNDINNSKSN NNNTNTNYNN NHNNTTTTTT     50
INKTEEKQND SPKDSEFEFL DELKGVDDQH HVFSSEDESY TNGNKKRKQT 100
DTPLSPNQDL KKRSITSPTT SPTTSTSTST STSTSTSTST IINNNNNNLK 150
DKTKEEIEFI KHIRSQLVKP KFLKDKPNFP LRSSGGNWIF VGKLPSLQST 200
TTDNTTLMSP NNATTTNGSS SNISTTTTTT TTTTPTTKIL YRVNGFLSDN 250
ETIDSIEINF GDPRDRYEIE RLHSSRINNP FELPCVSFKN PLFIKSNIAK 300
DIGISNEYGG MNDSFEFSNQ PPPPSPPPPP PPTLPPPPPP TLPPQHSLEQ 350
QSTKQQIFTQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQIPKINQQH 400
YSTQPSVLID DIYDPSNPTE PISPHQDHYP NFIFSKLQRY EHLPTRNPIS 450
QYDYRDRPRD WERDRDRDWE RDRDWERDRD RERDRDRDRD WERDRDWERD 500
RDWERDRDRD RDWERDRDRD WERDRDRDWE RDRERDRDRY DRQTNFSPAP 550
QSTTTSASTS STTSSTDKNS NNTTSTSVSA TTSTTKRKSK FSEPIEPSPF 600
AIQIPRDNIK INGNLINNSS SSSSSGNNNN NNNNNNNNNN NNNNNNNNNN 650
NNNNNSNNNN NNSDVKDIKD KLLKQFKIYD PVNVYMDESY WYIDFRSSES 700
RERAIQVLNG SFIDTWKLNV DNKKTNTINE ELQKQKQLEN DSNNNKPNNF 750
NLLENERSLK EICKLLVATE LLSTSSKDIS KNFIEAEILK TIKLLDSQRI 800
DPLTQNSTII NNTTNTTTSN INNTSNNTTV TPIVTPKSII SAPTSRDSPR 850
GGRSSSTTTK KPSKLDLNGS GVPPTLKKLD TIKQQQQPQP PLSPLKRPPK 900
SHFYSDSEDD GNNNNDDDDD DDDDEDDDFD QELSPLHSSR DSKKNIKSII 950
KKKPIYSDDD DDHYHHHNHH HNHHHHHHHD RSEVELYNES DLQVDVLDSD 1000
NENQDESDYH KSSDNFGHVE LSDDDNEFDS LDTDQDLYDT EENDNGKKSN 1050
KRPRKSKFNG KSKKPTTTTS TTTTATKSKG RSKKTTITTP THNIPVLDEI 1100
QSNLDDEDAS YVSMVMAADK DIKLLFSTKS EEGFEDSSQE ILSTPTRTKP 1150
SRNRKERNLP FLDEEDDESF KQLPQPQQKQ EKQEKHEHKL KNKELKQKNN 1200
EVIINKTEEH FSENLNGDNN NNNDKSENEN ENENENKNEN ENDNNNLNTS 1250
IDNINGVERR SITGCARSEG YTRSDIQKLF KRKQVAPTGK RGAASSASSG 1300
SNSSSSSTAE SFETGGNLSK SARSSRFDNR GFGSDPITLA SLKSRRKRIK 1350
FERSDIHDWG LFAMETISAK DMVIEYIGEV IRQKVADERE KRYVKKGIGS 1400
SYLFRVDDDT IIDATFKGNL ARFINHCCDP NCIAKVLTIG NQKKIIIYAK 1450
RDINIGEEIT YDYKFPIEDV KIPCLCKSPK CRQTLN 1486
Length:1,486
Mass (Da):170,527
Last modified:May 24, 2005 - v1
Checksum:iF46F71F1A5DFBFFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000132 Genomic DNA. Translation: EAL62816.1.
RefSeqiXP_636258.1. XM_631166.1.

Genome annotation databases

EnsemblProtistsiDDB0233375; DDB0233375; DDB_G0289257.
GeneIDi8627040.
KEGGiddi:DDB_G0289257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000132 Genomic DNA. Translation: EAL62816.1 .
RefSeqi XP_636258.1. XM_631166.1.

3D structure databases

ProteinModelPortali Q54HS3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0233375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233375 ; DDB0233375 ; DDB_G0289257 .
GeneIDi 8627040.
KEGGi ddi:DDB_G0289257.

Organism-specific databases

dictyBasei DDB_G0289257. set1.

Phylogenomic databases

eggNOGi COG2940.
InParanoidi Q54HS3.
KOi K11422.
OMAi WERDRDW.

Miscellaneous databases

PROi Q54HS3.

Family and domain databases

InterProi IPR003616. Post-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase."
    Chubb J.R., Bloomfield G., Xu Q., Kaller M., Ivens A., Skelton J., Turner B.M., Nellen W., Shaulsky G., Kay R.R., Bickmore W.A., Singer R.H.
    Dev. Biol. 292:519-532(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION, MUTAGENESIS OF ASN-1425 AND CYS-1474, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSET1_DICDI
AccessioniPrimary (citable) accession number: Q54HS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3