Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q54HS3

- SET1_DICDI

UniProt

Q54HS3 - SET1_DICDI

Protein

Histone-lysine N-methyltransferase set1

Gene

set1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Histone methyltransferase that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. May act to regulate chromatin-mediated events.1 Publication

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K4 specific) Source: dictyBase

    GO - Biological processi

    1. aggregation involved in sorocarp development Source: dictyBase
    2. histone H3-K4 methylation Source: GOC
    3. histone methylation Source: dictyBase
    4. regulation of gene expression, epigenetic Source: dictyBase

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase set1 (EC:2.1.1.43)
    Alternative name(s):
    Histone H3 lysine 4 methyltransferase
    SET domain-containing protein 1
    Gene namesi
    Name:set1
    Synonyms:H3K4
    ORF Names:DDB_G0289257
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0289257. set1.

    Subcellular locationi

    Nucleus 1 Publication. Chromosome 1 Publication

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: dictyBase

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Cells display unusually rapid development, characterized by precocious aggregation into multicellular aggregates, and completely lack mono-, di- and trimethylation of H3K4 ('Lys-5' of histone 3). Cells also induce premature differentiation.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1425 – 14251N → Q: Loss of catalytic activity; when associated with Ala-1474. 1 Publication
    Mutagenesisi1474 – 14741C → A: Loss of catalytic activity; when associated with Gln-1425. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14861486Histone-lysine N-methyltransferase set1PRO_0000379483Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0233375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54HS3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1347 – 1464118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1470 – 148617Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili359 – 40042Sequence AnalysisAdd
    BLAST
    Coiled coili717 – 74428Sequence AnalysisAdd
    BLAST
    Coiled coili1177 – 125579Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 4415Poly-AsnAdd
    BLAST
    Compositional biasi45 – 506Poly-Thr
    Compositional biasi116 – 14025Thr-richAdd
    BLAST
    Compositional biasi143 – 1486Poly-Asn
    Compositional biasi225 – 23713Poly-ThrAdd
    BLAST
    Compositional biasi321 – 33212Poly-ProAdd
    BLAST
    Compositional biasi335 – 3406Poly-Pro
    Compositional biasi360 – 39233Poly-GlnAdd
    BLAST
    Compositional biasi455 – 54288Arg-richAdd
    BLAST
    Compositional biasi553 – 58533Thr-richAdd
    BLAST
    Compositional biasi619 – 6257Poly-Ser
    Compositional biasi627 – 66236Poly-AsnAdd
    BLAST
    Compositional biasi884 – 8896Poly-Gln
    Compositional biasi912 – 9154Poly-Asn
    Compositional biasi916 – 93015Poly-AspAdd
    BLAST
    Compositional biasi958 – 9625Poly-Asp
    Compositional biasi963 – 97917Poly-HisAdd
    BLAST
    Compositional biasi1066 – 107611Poly-ThrAdd
    BLAST
    Compositional biasi1219 – 12235Poly-Asn
    Compositional biasi1295 – 130713Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG2940.
    InParanoidiQ54HS3.
    KOiK11422.
    OMAiWERDRDW.

    Family and domain databases

    InterProiIPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54HS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENETIVDNS LNNKSNVNNS NNDINNSKSN NNNTNTNYNN NHNNTTTTTT     50
    INKTEEKQND SPKDSEFEFL DELKGVDDQH HVFSSEDESY TNGNKKRKQT 100
    DTPLSPNQDL KKRSITSPTT SPTTSTSTST STSTSTSTST IINNNNNNLK 150
    DKTKEEIEFI KHIRSQLVKP KFLKDKPNFP LRSSGGNWIF VGKLPSLQST 200
    TTDNTTLMSP NNATTTNGSS SNISTTTTTT TTTTPTTKIL YRVNGFLSDN 250
    ETIDSIEINF GDPRDRYEIE RLHSSRINNP FELPCVSFKN PLFIKSNIAK 300
    DIGISNEYGG MNDSFEFSNQ PPPPSPPPPP PPTLPPPPPP TLPPQHSLEQ 350
    QSTKQQIFTQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQIPKINQQH 400
    YSTQPSVLID DIYDPSNPTE PISPHQDHYP NFIFSKLQRY EHLPTRNPIS 450
    QYDYRDRPRD WERDRDRDWE RDRDWERDRD RERDRDRDRD WERDRDWERD 500
    RDWERDRDRD RDWERDRDRD WERDRDRDWE RDRERDRDRY DRQTNFSPAP 550
    QSTTTSASTS STTSSTDKNS NNTTSTSVSA TTSTTKRKSK FSEPIEPSPF 600
    AIQIPRDNIK INGNLINNSS SSSSSGNNNN NNNNNNNNNN NNNNNNNNNN 650
    NNNNNSNNNN NNSDVKDIKD KLLKQFKIYD PVNVYMDESY WYIDFRSSES 700
    RERAIQVLNG SFIDTWKLNV DNKKTNTINE ELQKQKQLEN DSNNNKPNNF 750
    NLLENERSLK EICKLLVATE LLSTSSKDIS KNFIEAEILK TIKLLDSQRI 800
    DPLTQNSTII NNTTNTTTSN INNTSNNTTV TPIVTPKSII SAPTSRDSPR 850
    GGRSSSTTTK KPSKLDLNGS GVPPTLKKLD TIKQQQQPQP PLSPLKRPPK 900
    SHFYSDSEDD GNNNNDDDDD DDDDEDDDFD QELSPLHSSR DSKKNIKSII 950
    KKKPIYSDDD DDHYHHHNHH HNHHHHHHHD RSEVELYNES DLQVDVLDSD 1000
    NENQDESDYH KSSDNFGHVE LSDDDNEFDS LDTDQDLYDT EENDNGKKSN 1050
    KRPRKSKFNG KSKKPTTTTS TTTTATKSKG RSKKTTITTP THNIPVLDEI 1100
    QSNLDDEDAS YVSMVMAADK DIKLLFSTKS EEGFEDSSQE ILSTPTRTKP 1150
    SRNRKERNLP FLDEEDDESF KQLPQPQQKQ EKQEKHEHKL KNKELKQKNN 1200
    EVIINKTEEH FSENLNGDNN NNNDKSENEN ENENENKNEN ENDNNNLNTS 1250
    IDNINGVERR SITGCARSEG YTRSDIQKLF KRKQVAPTGK RGAASSASSG 1300
    SNSSSSSTAE SFETGGNLSK SARSSRFDNR GFGSDPITLA SLKSRRKRIK 1350
    FERSDIHDWG LFAMETISAK DMVIEYIGEV IRQKVADERE KRYVKKGIGS 1400
    SYLFRVDDDT IIDATFKGNL ARFINHCCDP NCIAKVLTIG NQKKIIIYAK 1450
    RDINIGEEIT YDYKFPIEDV KIPCLCKSPK CRQTLN 1486
    Length:1,486
    Mass (Da):170,527
    Last modified:May 24, 2005 - v1
    Checksum:iF46F71F1A5DFBFFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000132 Genomic DNA. Translation: EAL62816.1.
    RefSeqiXP_636258.1. XM_631166.1.

    Genome annotation databases

    EnsemblProtistsiDDB0233375; DDB0233375; DDB_G0289257.
    GeneIDi8627040.
    KEGGiddi:DDB_G0289257.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000132 Genomic DNA. Translation: EAL62816.1 .
    RefSeqi XP_636258.1. XM_631166.1.

    3D structure databases

    ProteinModelPortali Q54HS3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0233375.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233375 ; DDB0233375 ; DDB_G0289257 .
    GeneIDi 8627040.
    KEGGi ddi:DDB_G0289257.

    Organism-specific databases

    dictyBasei DDB_G0289257. set1.

    Phylogenomic databases

    eggNOGi COG2940.
    InParanoidi Q54HS3.
    KOi K11422.
    OMAi WERDRDW.

    Miscellaneous databases

    PROi Q54HS3.

    Family and domain databases

    InterProi IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase."
      Chubb J.R., Bloomfield G., Xu Q., Kaller M., Ivens A., Skelton J., Turner B.M., Nellen W., Shaulsky G., Kay R.R., Bickmore W.A., Singer R.H.
      Dev. Biol. 292:519-532(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION, MUTAGENESIS OF ASN-1425 AND CYS-1474, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSET1_DICDI
    AccessioniPrimary (citable) accession number: Q54HS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3