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Q54HS3

- SET1_DICDI

UniProt

Q54HS3 - SET1_DICDI

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Protein

Histone-lysine N-methyltransferase set1

Gene

set1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Histone methyltransferase that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. May act to regulate chromatin-mediated events.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K4 specific) Source: dictyBase

GO - Biological processi

  1. aggregation involved in sorocarp development Source: dictyBase
  2. histone H3-K4 methylation Source: GOC
  3. histone methylation Source: dictyBase
  4. regulation of gene expression, epigenetic Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase set1 (EC:2.1.1.43)
Alternative name(s):
Histone H3 lysine 4 methyltransferase
SET domain-containing protein 1
Gene namesi
Name:set1
Synonyms:H3K4
ORF Names:DDB_G0289257
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289257. set1.

Subcellular locationi

Nucleus 1 Publication. Chromosome 1 Publication

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Cells display unusually rapid development, characterized by precocious aggregation into multicellular aggregates, and completely lack mono-, di- and trimethylation of H3K4 ('Lys-5' of histone 3). Cells also induce premature differentiation.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1425 – 14251N → Q: Loss of catalytic activity; when associated with Ala-1474. 1 Publication
Mutagenesisi1474 – 14741C → A: Loss of catalytic activity; when associated with Gln-1425. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14861486Histone-lysine N-methyltransferase set1PRO_0000379483Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0233375.

Structurei

3D structure databases

ProteinModelPortaliQ54HS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1347 – 1464118SETPROSITE-ProRule annotationAdd
BLAST
Domaini1470 – 148617Post-SETPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili359 – 40042Sequence AnalysisAdd
BLAST
Coiled coili717 – 74428Sequence AnalysisAdd
BLAST
Coiled coili1177 – 125579Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 4415Poly-AsnAdd
BLAST
Compositional biasi45 – 506Poly-Thr
Compositional biasi116 – 14025Thr-richAdd
BLAST
Compositional biasi143 – 1486Poly-Asn
Compositional biasi225 – 23713Poly-ThrAdd
BLAST
Compositional biasi321 – 33212Poly-ProAdd
BLAST
Compositional biasi335 – 3406Poly-Pro
Compositional biasi360 – 39233Poly-GlnAdd
BLAST
Compositional biasi455 – 54288Arg-richAdd
BLAST
Compositional biasi553 – 58533Thr-richAdd
BLAST
Compositional biasi619 – 6257Poly-Ser
Compositional biasi627 – 66236Poly-AsnAdd
BLAST
Compositional biasi884 – 8896Poly-Gln
Compositional biasi912 – 9154Poly-Asn
Compositional biasi916 – 93015Poly-AspAdd
BLAST
Compositional biasi958 – 9625Poly-Asp
Compositional biasi963 – 97917Poly-HisAdd
BLAST
Compositional biasi1066 – 107611Poly-ThrAdd
BLAST
Compositional biasi1219 – 12235Poly-Asn
Compositional biasi1295 – 130713Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ54HS3.
KOiK11422.
OMAiWERDRDW.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54HS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENETIVDNS LNNKSNVNNS NNDINNSKSN NNNTNTNYNN NHNNTTTTTT
60 70 80 90 100
INKTEEKQND SPKDSEFEFL DELKGVDDQH HVFSSEDESY TNGNKKRKQT
110 120 130 140 150
DTPLSPNQDL KKRSITSPTT SPTTSTSTST STSTSTSTST IINNNNNNLK
160 170 180 190 200
DKTKEEIEFI KHIRSQLVKP KFLKDKPNFP LRSSGGNWIF VGKLPSLQST
210 220 230 240 250
TTDNTTLMSP NNATTTNGSS SNISTTTTTT TTTTPTTKIL YRVNGFLSDN
260 270 280 290 300
ETIDSIEINF GDPRDRYEIE RLHSSRINNP FELPCVSFKN PLFIKSNIAK
310 320 330 340 350
DIGISNEYGG MNDSFEFSNQ PPPPSPPPPP PPTLPPPPPP TLPPQHSLEQ
360 370 380 390 400
QSTKQQIFTQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQIPKINQQH
410 420 430 440 450
YSTQPSVLID DIYDPSNPTE PISPHQDHYP NFIFSKLQRY EHLPTRNPIS
460 470 480 490 500
QYDYRDRPRD WERDRDRDWE RDRDWERDRD RERDRDRDRD WERDRDWERD
510 520 530 540 550
RDWERDRDRD RDWERDRDRD WERDRDRDWE RDRERDRDRY DRQTNFSPAP
560 570 580 590 600
QSTTTSASTS STTSSTDKNS NNTTSTSVSA TTSTTKRKSK FSEPIEPSPF
610 620 630 640 650
AIQIPRDNIK INGNLINNSS SSSSSGNNNN NNNNNNNNNN NNNNNNNNNN
660 670 680 690 700
NNNNNSNNNN NNSDVKDIKD KLLKQFKIYD PVNVYMDESY WYIDFRSSES
710 720 730 740 750
RERAIQVLNG SFIDTWKLNV DNKKTNTINE ELQKQKQLEN DSNNNKPNNF
760 770 780 790 800
NLLENERSLK EICKLLVATE LLSTSSKDIS KNFIEAEILK TIKLLDSQRI
810 820 830 840 850
DPLTQNSTII NNTTNTTTSN INNTSNNTTV TPIVTPKSII SAPTSRDSPR
860 870 880 890 900
GGRSSSTTTK KPSKLDLNGS GVPPTLKKLD TIKQQQQPQP PLSPLKRPPK
910 920 930 940 950
SHFYSDSEDD GNNNNDDDDD DDDDEDDDFD QELSPLHSSR DSKKNIKSII
960 970 980 990 1000
KKKPIYSDDD DDHYHHHNHH HNHHHHHHHD RSEVELYNES DLQVDVLDSD
1010 1020 1030 1040 1050
NENQDESDYH KSSDNFGHVE LSDDDNEFDS LDTDQDLYDT EENDNGKKSN
1060 1070 1080 1090 1100
KRPRKSKFNG KSKKPTTTTS TTTTATKSKG RSKKTTITTP THNIPVLDEI
1110 1120 1130 1140 1150
QSNLDDEDAS YVSMVMAADK DIKLLFSTKS EEGFEDSSQE ILSTPTRTKP
1160 1170 1180 1190 1200
SRNRKERNLP FLDEEDDESF KQLPQPQQKQ EKQEKHEHKL KNKELKQKNN
1210 1220 1230 1240 1250
EVIINKTEEH FSENLNGDNN NNNDKSENEN ENENENKNEN ENDNNNLNTS
1260 1270 1280 1290 1300
IDNINGVERR SITGCARSEG YTRSDIQKLF KRKQVAPTGK RGAASSASSG
1310 1320 1330 1340 1350
SNSSSSSTAE SFETGGNLSK SARSSRFDNR GFGSDPITLA SLKSRRKRIK
1360 1370 1380 1390 1400
FERSDIHDWG LFAMETISAK DMVIEYIGEV IRQKVADERE KRYVKKGIGS
1410 1420 1430 1440 1450
SYLFRVDDDT IIDATFKGNL ARFINHCCDP NCIAKVLTIG NQKKIIIYAK
1460 1470 1480
RDINIGEEIT YDYKFPIEDV KIPCLCKSPK CRQTLN
Length:1,486
Mass (Da):170,527
Last modified:May 24, 2005 - v1
Checksum:iF46F71F1A5DFBFFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000132 Genomic DNA. Translation: EAL62816.1.
RefSeqiXP_636258.1. XM_631166.1.

Genome annotation databases

EnsemblProtistsiDDB0233375; DDB0233375; DDB_G0289257.
GeneIDi8627040.
KEGGiddi:DDB_G0289257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000132 Genomic DNA. Translation: EAL62816.1 .
RefSeqi XP_636258.1. XM_631166.1.

3D structure databases

ProteinModelPortali Q54HS3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0233375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233375 ; DDB0233375 ; DDB_G0289257 .
GeneIDi 8627040.
KEGGi ddi:DDB_G0289257.

Organism-specific databases

dictyBasei DDB_G0289257. set1.

Phylogenomic databases

eggNOGi COG2940.
InParanoidi Q54HS3.
KOi K11422.
OMAi WERDRDW.

Miscellaneous databases

PROi Q54HS3.

Family and domain databases

InterProi IPR003616. Post-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase."
    Chubb J.R., Bloomfield G., Xu Q., Kaller M., Ivens A., Skelton J., Turner B.M., Nellen W., Shaulsky G., Kay R.R., Bickmore W.A., Singer R.H.
    Dev. Biol. 292:519-532(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION, MUTAGENESIS OF ASN-1425 AND CYS-1474, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSET1_DICDI
AccessioniPrimary (citable) accession number: Q54HS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3