Reviewed, UniProtKB/Swiss-Prot Q54H71 (ADRPH_DICDI)

Names and origin

Protein names

Recommended name:
    [Protein ADP-ribosylarginine] hydrolase
      Short name=ADP-ribosylarginine hydrolase
    EC=3.2.2.19
Alternative name(s):
    ADP-ribose-L-arginine cleaving enzyme

Gene names

Name:	adprh
ORF Names:	DDB_G0289675

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reverse reaction of mono-ADP-ribosylation By similarity.
Catalytic activity	Protein-N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-ribose + protein-L-arginine. N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-ribose + L-arginine.
Sequence similarities	Belongs to the ADP-ribosylglycohydrolase family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid de-ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Molecular function	ADP-ribosylarginine hydrolase activity Inferred from sequence or structural similarity. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	[Protein ADP-ribosylarginine] hydrolase		PRO_0000328209

Sequences

	Sequence		Length	Mass (Da)
	Q54H71-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: B99C7063F05AB67C	FASTA	392	44,362
	10 20 30 40 50 60 MFHKFISTLT NKKITQTIMG TINKENIKPA MLLSAFGDAC GYKNGIWEFE KSPSRIYEHY 70 80 90 100 110 120 EYLGGYKNLK INKKDWRLSD DTIMHIATAI AITRPTNTDN ESICKELAKA YIHSMEDMAG 130 140 150 160 170 180 RAPGIQTINS VSLMTQTGMR SKVYQWNEID FSDRAGGCGG SMRSMCIGFK YWSDEQLDTL 190 200 210 220 230 240 IELSIESGRI THNNPVGFLG ALVSALFASY AIRSIPPKTW PLKLMTEVMP KAREYLEKTS 250 260 270 280 290 300 NSSNRNIENY EKGWNYFWNS WKSYLKLRQI PSNPDELKAA NDKGIDYPVF PKDYSDYKVR 310 320 330 340 350 360 ENFYHSISFS GWGGSSGHDS CIIAYDALLG SADNWEEMIK RSVLHGGDND STGAIGCCWW 370 380 390 GALYGFNGVP ECNYEKIEYK SIIEGLAKEI SN

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000148 Genomic DNA. Translation: EAL62549.1.
RefSeq	XP_636047.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3387663.
GenomeReviews	Gene locus adprh in contig CM000154_GR.
KEGG	ddi:DDB_0238599.
Organism-specific databases
dictyBase	DDB_G0289675. adprh.
Phylogenomic databases
OMA	IPFNSHE.
Enzyme and pathway databases
BRENDA	3.2.2.19. 424.
Family and domain databases
InterPro	IPR012108. ADP-ribosylarg_hydro. IPR005502. Ribosyl_crysJ1. [Graphical view]
PANTHER	PTHR22957:SF7. ADP-ribosylarg_hydro. 1 hit.
Pfam	PF03747. ADP_ribosyl_GH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADRPH_DICDI

Accession

Primary (citable) accession number: Q54H71

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)