Q54H38 (ABHD_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Abhydrolase domain-containing protein
EC=3.1.1.-

Gene names

Name:	abhd
ORF Names:	DDB_G0289723

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	phagocytic vesicle Inferred from direct assay Ref.2. Source: dictyBase
Molecular function	carboxylesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Abhydrolase domain-containing protein		PRO_0000344505
Sites
	Active site	200	1	Charge relay system By similarity
	Active site	327	1	Charge relay system By similarity
	Active site	356	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54H38 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 228ED9FB2F1D1381	FASTA	395	45,168
	10 20 30 40 50 60 MFSSRDKAEV KLYFDSNNEE NQKILDQCPH LYQKYDKDVT INDRINNIED SEPTIKNGVT 70 80 90 100 110 120 FYPPYYLYNS HFMNYYGSYK IPKLNLKTRR EILVNPIDGG TISLDFFELG EFKEDTPTIV 130 140 150 160 170 180 INHGLTGGSH ERYVQYFAQR AYKEKGFRSV VFNYRGCAGN PITADRAYSA VQLDDIKFVT 190 200 210 220 230 240 EYLTKTALPL VKKWFLVGFS LGSAILVNYM ADAGKDSPYL AHVSISNPMN MVECTKNLSS 250 260 270 280 290 300 TYINNLIYNK GLANNLKRLF RKFDGRLDKY ATKEQIMAAQ TIADFDDLIT SKMFGFETAH 310 320 330 340 350 360 DYYLAASSSK SIRNLVKPIL FINAIDDPIA PTSGFPWKDF KSNPNTILCV SRWGGHLGFI 370 380 390 SYEDHMSWSD KAAVEYLSTF LDDNNNNNDN DNKTE

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake." Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T. Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed: 16926386] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Strain: AX2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000148 Genomic DNA. Translation: EAL62573.1.
RefSeq	XP_636080.1. XM_630988.1.
3D structure databases
ProteinModelPortal	Q54H38.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54H38.
Proteomic databases
PRIDE	Q54H38.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0237966; DDB0237966; DDB_G0289723.
GeneID	8627292.
GenomeReviews	Gene locus abhd in contig CM000154_GR.
KEGG	ddi:DDB_G0289723.
Organism-specific databases
dictyBase	DDB_G0289723. abhd.
Phylogenomic databases
eggNOG	KOG1838.
GeneTree	EPrGT00050000005736.
OMA	DFAFIAK.
PhylomeDB	Q54H38.
Family and domain databases
InterPro	IPR012020. AB-Hydro_YheT. [Graphical view]
KO	K07019.
PIRSF	PIRSF005211. Ab_hydro_YheT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ABHD_DICDI

Accession

Primary (citable) accession number: Q54H38

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)