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Protein

Serine--pyruvate aminotransferase

Gene

agxt

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Dual metabolic roles of gluconeogenesis and glyoxylate detoxification.By similarity

Catalytic activityi

L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
L-alanine + glyoxylate = pyruvate + glycine.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei376SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-389661. Glyoxylate metabolism and glycine degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine--pyruvate aminotransferase (EC:2.6.1.51)
Short name:
SPT
Alternative name(s):
Alanine--glyoxylate aminotransferase (EC:2.6.1.44)
Short name:
AGT
Gene namesi
Name:agxt
ORF Names:DDB_G0289923
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289923. agxt.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003285871 – 407Serine--pyruvate aminotransferaseAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ54GT6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237978.

Structurei

3D structure databases

ProteinModelPortaliQ54GT6.
SMRiQ54GT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2862. Eukaryota.
COG0075. LUCA.
InParanoidiQ54GT6.
KOiK00830.
OMAiWGCDDKP.
PhylomeDBiQ54GT6.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54GT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYSDKHKLK TSNLQLPVRL LLGPGPSNLH PRVNQQLISS MVGYTDASYY
60 70 80 90 100
KVMDETMELM RYLFQTDNHF TIPISGAGTA AMETCVSNLI EPGDKVVCLV
110 120 130 140 150
SGFFSDRIYQ MAVRYGGNIL KVDKQWGQWF ALEEIESALV QHKPSLLTLV
160 170 180 190 200
FGETSTGVKQ QMEGVGELCK KYNCLLMVDC VAALGGVPVF VDDWKIDACY
210 220 230 240 250
TGTQKCLSGP PGISPLTFSN AACHKIATRK TPVANWYLDC NLLGGYWCPE
260 270 280 290 300
FNLADGTIAK EEKSTIPKRY HHTTPANLLY SLREALVLLV EEGLDNVWKR
310 320 330 340 350
HQDAAILLYA GLESLGLKPF VPQLNEAPEK GGRLFSLTTV NIPDGVDGKM
360 370 380 390 400
VMKYLLDNFN IEIAGGIGAF AGKVWRIGLM GQNANPGNIK LLISSLSDAL

KVNGFNC
Length:407
Mass (Da):44,711
Last modified:May 24, 2005 - v1
Checksum:iD5701FCFDB38DE50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000149 Genomic DNA. Translation: EAL62474.1.
RefSeqiXP_635983.1. XM_630891.1.

Genome annotation databases

EnsemblProtistsiEAL62474; EAL62474; DDB_G0289923.
GeneIDi8627398.
KEGGiddi:DDB_G0289923.

Similar proteinsi

Entry informationi

Entry nameiSPYA_DICDI
AccessioniPrimary (citable) accession number: Q54GT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: June 7, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families