Q54GQ6 (ACOX1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal acyl-coenzyme A oxidase 1
EC=1.3.3.6

Gene names

Name:	acox1
ORF Names:	DDB_G0289993

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs By similarity.
Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro generation of precursor metabolites and energy Inferred from sequence or structural similarity. Source: UniProtKB prostaglandin metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	peroxisome Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from sequence or structural similarity. Source: UniProtKB flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 700	700	Peroxisomal acyl-coenzyme A oxidase 1		PRO_0000330929
Regions
	Nucleotide binding	412 – 417	6	FAD By similarity
	Motif	698 – 700	3	Microbody targeting signal Potential
	Compositional bias	461 – 464	4	Poly-Gly
Sites
	Active site	437	1	Proton acceptor By similarity
	Binding site	147	1	FAD By similarity
	Binding site	186	1	FAD; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54GQ6 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 3F286207CFD33958	FASTA	700	79,762
	10 20 30 40 50 60 MYCPKAYENE KKNEDLEFER SQSTFSVSEL NFILNNNDHN IINIKNEIKK FIDNDEIISK 70 80 90 100 110 120 PQEIHFLSRE EQYKRALYVS SKLIEIKKRF GEIGRDQYYQ SLFEEIPFVI NDIVFACAFK 130 140 150 160 170 180 SLASDEQMNR LYSKFENYQY FGSYSQTEIG HGSNVQGIET TCTFIKETGE FELNSPNLTS 190 200 210 220 230 240 TKFWIGGLGK LATHTIVFAQ LLIPSSIDGK LKNYGPHPFI LQVRSLDDHS PLPGVTVGDI 250 260 270 280 290 300 GPKLGFNSID NGFLRLDHVR IPRENMLSRF FRVNEQGEYE KPKHPKLIYA GMVGVRSSMI 310 320 330 340 350 360 ENSFVSLSRA VTIAIRYSTI RKQFKSNRLD KQEKKIIEYS NQMNRIIPYL AQTFAYFFTG 370 380 390 400 410 420 KRFSIEFDQM MKAVKHNQDT TLLSELHANS SGLKSLMTQS TSDGIESCRL SCGGHGYSQF 430 440 450 460 470 480 SGLPYLWSNY VHMSSAEGES NLLPQQTTKY LLTILRKVLS GGGGSSDTTT ADDDNKPIGK 490 500 510 520 530 540 SVKYINDEFQ SSFENINQFI QEKGLNSIIH PDSLLQLFKH RSFILIKSIA ESIQEQMSNG 550 560 570 580 590 600 NKDIPQIWSD LNVEINHCSK AHCQLYVIQS FYDQILLLSS NSSSCSSSIT TVLIQLLQTY 610 620 630 640 650 660 SIWIINSNLV DFLQDQYVEL SQIDFLKKSL INFYKLLRPN LVPLVDSFDL CNTTLGSALG 670 680 690 700 SYNGDVYSTL YKWASTQPFN KNSLPLGFNE TIKPLINSKL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000150 Genomic DNA. Translation: EAL62442.1.
RefSeq	XP_635946.1. XM_630854.1.
3D structure databases
HSSP	HSSP built from PDB template 2DDH based on UniProtKB P07872.
ProteinModelPortal	Q54GQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54GQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0234154; DDB0234154; DDB_G0289993.
GeneID	8627428.
GenomeReviews	Gene locus acox1 in contig CM000154_GR.
KEGG	ddi:DDB_G0289993.
Organism-specific databases
dictyBase	DDB_G0289993.
Phylogenomic databases
eggNOG	KOG0136.
GeneTree	EPrGT00050000005239.
HOGENOM	HBG737904.
OMA	IRERENC.
PhylomeDB	Q54GQ6.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR023570. Acyl-CoA_oxidase_perosiome. IPR009075. AcylCo_DH/oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR009100. AcylCoA_DH/oxidase. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
KO	K00232.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAM	SSF56645. AcylCoA_dehyd_NM. 1 hit. SSF47203. AcylCoADH_C_like. 2 hits.
ProtoNet	Search...

Entry information

Entry name

ACOX1_DICDI

Accession

Primary (citable) accession number: Q54GQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)