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Protein

Inositol oxygenase

Gene

miox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathway:imyo-inositol degradation into D-glucuronate

This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol.
Proteins known to be involved in this subpathway in this organism are:
  1. Inositol oxygenase (miox)
This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo-inositol, the pathway myo-inositol degradation into D-glucuronate and in Polyol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331SubstrateBy similarity
Metal bindingi101 – 1011Iron 1By similarity
Metal bindingi128 – 1281Iron 1By similarity
Metal bindingi129 – 1291Iron 1By similarity
Metal bindingi129 – 1291Iron 2By similarity
Binding sitei132 – 1321SubstrateBy similarity
Metal bindingi201 – 2011Iron 2By similarity
Metal bindingi227 – 2271Iron 2By similarity
Metal bindingi260 – 2601Iron 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:miox
ORF Names:DDB_G0290161
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290161. miox.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Inositol oxygenasePRO_0000328413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235367.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 903Substrate bindingBy similarity
Regioni149 – 1502Substrate bindingBy similarity
Regioni227 – 2282Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

eggNOGiNOG135479.
InParanoidiQ54GH4.
KOiK00469.
OMAiMHAPEIN.
PhylomeDBiQ54GH4.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54GH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIETRTTTST SEIKHDNSLK TGFEITKEVE EFRNYENSED RVSEAYRNSH
60 70 80 90 100
TYQTYDYATE KKKQYSQLDT SIKMGLWEAA ELLNTIIDES DPDSNIPQIN
110 120 130 140 150
HCLQTAEAIR KVYPDSKYDW FHLTGFIHDL GKVLLSKKFK EQPQWATVGD
160 170 180 190 200
TFPLGCKFDE SNIFYEFFKM NPDYNDSKYN SECGIYKKNI GLENVTMSWG
210 220 230 240 250
HDEYFYLVCV GNKCLLPKES LYMIRFHSFY PWHRHNKYTH LTNEEDEKML
260 270 280 290
NWVKEFNKFD LYSKDSEPVD VESLKPYYQS LISKYFPNEL HW
Length:292
Mass (Da):34,801
Last modified:May 24, 2005 - v1
Checksum:i4F4D1E483BECFF8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000158 Genomic DNA. Translation: EAL62352.1.
RefSeqiXP_635854.1. XM_630762.1.

Genome annotation databases

EnsemblProtistsiDDB0235367; DDB0235367; DDB_G0290161.
GeneIDi8627510.
KEGGiddi:DDB_G0290161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000158 Genomic DNA. Translation: EAL62352.1.
RefSeqiXP_635854.1. XM_630762.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0235367.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0235367; DDB0235367; DDB_G0290161.
GeneIDi8627510.
KEGGiddi:DDB_G0290161.

Organism-specific databases

dictyBaseiDDB_G0290161. miox.

Phylogenomic databases

eggNOGiNOG135479.
InParanoidiQ54GH4.
KOiK00469.
OMAiMHAPEIN.
PhylomeDBiQ54GH4.

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Miscellaneous databases

PROiQ54GH4.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMIOX_DICDI
AccessioniPrimary (citable) accession number: Q54GH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 22, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.