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Q54GH4

- MIOX_DICDI

UniProt

Q54GH4 - MIOX_DICDI

Protein

Inositol oxygenase

Gene

miox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Myo-inositol + O2 = D-glucuronate + H2O.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331SubstrateBy similarity
    Metal bindingi101 – 1011Iron 1By similarity
    Metal bindingi128 – 1281Iron 1By similarity
    Metal bindingi129 – 1291Iron 1By similarity
    Metal bindingi129 – 1291Iron 2By similarity
    Binding sitei132 – 1321SubstrateBy similarity
    Metal bindingi201 – 2011Iron 2By similarity
    Metal bindingi227 – 2271Iron 2By similarity
    Metal bindingi260 – 2601Iron 1By similarity

    GO - Molecular functioni

    1. inositol oxygenase activity Source: UniProtKB-EC
    2. iron ion binding Source: InterPro
    3. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Source: dictyBase

    GO - Biological processi

    1. inositol catabolic process Source: dictyBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00111; UER00527.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol oxygenase (EC:1.13.99.1)
    Alternative name(s):
    Myo-inositol oxygenase
    Short name:
    MI oxygenase
    Gene namesi
    Name:miox
    ORF Names:DDB_G0290161
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0290161. miox.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Inositol oxygenasePRO_0000328413Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0188751.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni88 – 903Substrate bindingBy similarity
    Regioni149 – 1502Substrate bindingBy similarity
    Regioni227 – 2282Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the myo-inositol oxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG135479.
    KOiK00469.
    OMAiNGESERQ.
    PhylomeDBiQ54GH4.

    Family and domain databases

    InterProiIPR007828. Inositol_oxygenase.
    [Graphical view]
    PANTHERiPTHR12588. PTHR12588. 1 hit.
    PfamiPF05153. DUF706. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54GH4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIETRTTTST SEIKHDNSLK TGFEITKEVE EFRNYENSED RVSEAYRNSH    50
    TYQTYDYATE KKKQYSQLDT SIKMGLWEAA ELLNTIIDES DPDSNIPQIN 100
    HCLQTAEAIR KVYPDSKYDW FHLTGFIHDL GKVLLSKKFK EQPQWATVGD 150
    TFPLGCKFDE SNIFYEFFKM NPDYNDSKYN SECGIYKKNI GLENVTMSWG 200
    HDEYFYLVCV GNKCLLPKES LYMIRFHSFY PWHRHNKYTH LTNEEDEKML 250
    NWVKEFNKFD LYSKDSEPVD VESLKPYYQS LISKYFPNEL HW 292
    Length:292
    Mass (Da):34,801
    Last modified:May 24, 2005 - v1
    Checksum:i4F4D1E483BECFF8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000158 Genomic DNA. Translation: EAL62352.1.
    RefSeqiXP_635854.1. XM_630762.1.

    Genome annotation databases

    EnsemblProtistsiDDB0235367; DDB0235367; DDB_G0290161.
    GeneIDi8627510.
    KEGGiddi:DDB_G0290161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000158 Genomic DNA. Translation: EAL62352.1 .
    RefSeqi XP_635854.1. XM_630762.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0188751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0235367 ; DDB0235367 ; DDB_G0290161 .
    GeneIDi 8627510.
    KEGGi ddi:DDB_G0290161.

    Organism-specific databases

    dictyBasei DDB_G0290161. miox.

    Phylogenomic databases

    eggNOGi NOG135479.
    KOi K00469.
    OMAi NGESERQ.
    PhylomeDBi Q54GH4.

    Enzyme and pathway databases

    UniPathwayi UPA00111 ; UER00527 .

    Miscellaneous databases

    PROi Q54GH4.

    Family and domain databases

    InterProi IPR007828. Inositol_oxygenase.
    [Graphical view ]
    PANTHERi PTHR12588. PTHR12588. 1 hit.
    Pfami PF05153. DUF706. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiMIOX_DICDI
    AccessioniPrimary (citable) accession number: Q54GH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3