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Q54GH4 (MIOX_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol oxygenase

EC=1.13.99.1
Alternative name(s):
Myo-inositol oxygenase
Short name=MI oxygenase
Gene names
Name:miox
ORF Names:DDB_G0290161
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the myo-inositol oxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Inositol oxygenase
PRO_0000328413

Regions

Region88 – 903Substrate binding By similarity
Region149 – 1502Substrate binding By similarity
Region227 – 2282Substrate binding By similarity

Sites

Metal binding1011Iron 1 By similarity
Metal binding1281Iron 1 By similarity
Metal binding1291Iron 1 By similarity
Metal binding1291Iron 2 By similarity
Metal binding2011Iron 2 By similarity
Metal binding2271Iron 2 By similarity
Metal binding2601Iron 1 By similarity
Binding site331Substrate By similarity
Binding site1321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54GH4 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 4F4D1E483BECFF8E

FASTA29234,801
        10         20         30         40         50         60 
MIETRTTTST SEIKHDNSLK TGFEITKEVE EFRNYENSED RVSEAYRNSH TYQTYDYATE 

        70         80         90        100        110        120 
KKKQYSQLDT SIKMGLWEAA ELLNTIIDES DPDSNIPQIN HCLQTAEAIR KVYPDSKYDW 

       130        140        150        160        170        180 
FHLTGFIHDL GKVLLSKKFK EQPQWATVGD TFPLGCKFDE SNIFYEFFKM NPDYNDSKYN 

       190        200        210        220        230        240 
SECGIYKKNI GLENVTMSWG HDEYFYLVCV GNKCLLPKES LYMIRFHSFY PWHRHNKYTH 

       250        260        270        280        290 
LTNEEDEKML NWVKEFNKFD LYSKDSEPVD VESLKPYYQS LISKYFPNEL HW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000158 Genomic DNA. Translation: EAL62352.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0188751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0235367; DDB0235367; DDB_G0290161.
KEGGddi:DDB_G0290161.

Organism-specific databases

dictyBaseDDB_G0290161. miox.

Phylogenomic databases

eggNOGNOG135479.
KOK00469.
OMACQFSDKI.
PhylomeDBQ54GH4.
ProtClustDBCLSZ2429697.

Enzyme and pathway databases

UniPathwayUPA00111; UER00527.

Family and domain databases

InterProIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERPTHR12588. PTHR12588. 1 hit.
PfamPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54GH4.

Entry information

Entry nameMIOX_DICDI
AccessionPrimary (citable) accession number: Q54GH4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase