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Protein

Inositol oxygenase

Gene

miox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: myo-inositol degradation into D-glucuronate

This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol.
Proteins known to be involved in this subpathway in this organism are:
  1. Inositol oxygenase (miox)
This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo-inositol, the pathway myo-inositol degradation into D-glucuronate and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33SubstrateBy similarity1
Metal bindingi101Iron 1By similarity1
Metal bindingi128Iron 1By similarity1
Metal bindingi129Iron 1By similarity1
Metal bindingi129Iron 2By similarity1
Binding sitei132SubstrateBy similarity1
Metal bindingi201Iron 2By similarity1
Metal bindingi227Iron 2By similarity1
Metal bindingi260Iron 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DDI-1855183 Synthesis of IP2, IP, and Ins in the cytosol
UniPathwayiUPA00111; UER00527

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:miox
ORF Names:DDB_G0290161
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290161 miox

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003284131 – 292Inositol oxygenaseAdd BLAST292

Proteomic databases

PaxDbiQ54GH4
PRIDEiQ54GH4

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235367

Structurei

3D structure databases

SMRiQ54GH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Substrate bindingBy similarity3
Regioni149 – 150Substrate bindingBy similarity2
Regioni227 – 228Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1573 Eukaryota
ENOG410XQ4J LUCA
InParanoidiQ54GH4
KOiK00469
OMAiHEKQTVA
PhylomeDBiQ54GH4

Family and domain databases

InterProiView protein in InterPro
IPR007828 Inositol_oxygenase
PANTHERiPTHR12588 PTHR12588, 1 hit
PfamiView protein in Pfam
PF05153 MIOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q54GH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIETRTTTST SEIKHDNSLK TGFEITKEVE EFRNYENSED RVSEAYRNSH
60 70 80 90 100
TYQTYDYATE KKKQYSQLDT SIKMGLWEAA ELLNTIIDES DPDSNIPQIN
110 120 130 140 150
HCLQTAEAIR KVYPDSKYDW FHLTGFIHDL GKVLLSKKFK EQPQWATVGD
160 170 180 190 200
TFPLGCKFDE SNIFYEFFKM NPDYNDSKYN SECGIYKKNI GLENVTMSWG
210 220 230 240 250
HDEYFYLVCV GNKCLLPKES LYMIRFHSFY PWHRHNKYTH LTNEEDEKML
260 270 280 290
NWVKEFNKFD LYSKDSEPVD VESLKPYYQS LISKYFPNEL HW
Length:292
Mass (Da):34,801
Last modified:May 24, 2005 - v1
Checksum:i4F4D1E483BECFF8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000158 Genomic DNA Translation: EAL62352.1
RefSeqiXP_635854.1, XM_630762.1

Genome annotation databases

EnsemblProtistsiEAL62352; EAL62352; DDB_G0290161
GeneIDi8627510
KEGGiddi:DDB_G0290161

Similar proteinsi

Entry informationi

Entry nameiMIOX_DICDI
AccessioniPrimary (citable) accession number: Q54GH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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