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Q54GH4

- MIOX_DICDI

UniProt

Q54GH4 - MIOX_DICDI

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Protein

Inositol oxygenase

Gene

miox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331SubstrateBy similarity
Metal bindingi101 – 1011Iron 1By similarity
Metal bindingi128 – 1281Iron 1By similarity
Metal bindingi129 – 1291Iron 1By similarity
Metal bindingi129 – 1291Iron 2By similarity
Binding sitei132 – 1321SubstrateBy similarity
Metal bindingi201 – 2011Iron 2By similarity
Metal bindingi227 – 2271Iron 2By similarity
Metal bindingi260 – 2601Iron 1By similarity

GO - Molecular functioni

  1. inositol oxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro
  3. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Source: dictyBase

GO - Biological processi

  1. inositol catabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:miox
ORF Names:DDB_G0290161
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290161. miox.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Inositol oxygenasePRO_0000328413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0188751.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 903Substrate bindingBy similarity
Regioni149 – 1502Substrate bindingBy similarity
Regioni227 – 2282Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

eggNOGiNOG135479.
InParanoidiQ54GH4.
KOiK00469.
OMAiNGESERQ.
PhylomeDBiQ54GH4.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54GH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIETRTTTST SEIKHDNSLK TGFEITKEVE EFRNYENSED RVSEAYRNSH
60 70 80 90 100
TYQTYDYATE KKKQYSQLDT SIKMGLWEAA ELLNTIIDES DPDSNIPQIN
110 120 130 140 150
HCLQTAEAIR KVYPDSKYDW FHLTGFIHDL GKVLLSKKFK EQPQWATVGD
160 170 180 190 200
TFPLGCKFDE SNIFYEFFKM NPDYNDSKYN SECGIYKKNI GLENVTMSWG
210 220 230 240 250
HDEYFYLVCV GNKCLLPKES LYMIRFHSFY PWHRHNKYTH LTNEEDEKML
260 270 280 290
NWVKEFNKFD LYSKDSEPVD VESLKPYYQS LISKYFPNEL HW
Length:292
Mass (Da):34,801
Last modified:May 24, 2005 - v1
Checksum:i4F4D1E483BECFF8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000158 Genomic DNA. Translation: EAL62352.1.
RefSeqiXP_635854.1. XM_630762.1.

Genome annotation databases

EnsemblProtistsiDDB0235367; DDB0235367; DDB_G0290161.
GeneIDi8627510.
KEGGiddi:DDB_G0290161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000158 Genomic DNA. Translation: EAL62352.1 .
RefSeqi XP_635854.1. XM_630762.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0188751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0235367 ; DDB0235367 ; DDB_G0290161 .
GeneIDi 8627510.
KEGGi ddi:DDB_G0290161.

Organism-specific databases

dictyBasei DDB_G0290161. miox.

Phylogenomic databases

eggNOGi NOG135479.
InParanoidi Q54GH4.
KOi K00469.
OMAi NGESERQ.
PhylomeDBi Q54GH4.

Enzyme and pathway databases

UniPathwayi UPA00111 ; UER00527 .

Miscellaneous databases

PROi Q54GH4.

Family and domain databases

InterProi IPR007828. Inositol_oxygenase.
[Graphical view ]
PANTHERi PTHR12588. PTHR12588. 1 hit.
Pfami PF05153. DUF706. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMIOX_DICDI
AccessioniPrimary (citable) accession number: Q54GH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3