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Protein

Probable malate dehydrogenase 1

Gene

mdhA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei149SubstrateBy similarity1
Binding sitei155SubstrateBy similarity1
Binding sitei162NADBy similarity1
Binding sitei169NADBy similarity1
Binding sitei188SubstrateBy similarity1
Binding sitei219SubstrateBy similarity1
Active sitei244Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 74NADBy similarity7
Nucleotide bindingi186 – 188NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

ReactomeiR-DDI-70263 Gluconeogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenase 1 (EC:1.1.1.37)
Gene namesi
Name:mdhA
ORF Names:DDB_G0290207
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290207 mdhA

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123651 – 391Probable malate dehydrogenase 1Add BLAST391

Proteomic databases

PaxDbiQ54GE6
PRIDEiQ54GE6

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230186

Structurei

3D structure databases

ProteinModelPortaliQ54GE6
SMRiQ54GE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.Curated

Phylogenomic databases

eggNOGiKOG1496 Eukaryota
COG0039 LUCA
InParanoidiQ54GE6
KOiK00025
OMAiYPDVHHC
PhylomeDBiQ54GE6

Family and domain databases

CDDicd01336 MDH_cytoplasmic_cytosolic, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR011274 Malate_DH_NAD-dep_euk
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
TIGR01758 MDH_euk_cyt, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q54GE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQAILRINN ISSQLTGKCP FKAHGGGAGK CPYKLGGGQI LDQSKAWSLV
60 70 80 90 100
NVTANVDQVT PIKVLVTGAA GQIAYSLMFM IASGQMFGPH QPVILHLLDI
110 120 130 140 150
PKMADALKGV VMELQDCSYP LLQSVVATTD IQTAFLHINV AILVGAFPRG
160 170 180 190 200
PGMQRKDLLK VNVSIFKEQG EALNKYASRG VKVLVVGNPA NTNALTALMK
210 220 230 240 250
ASDLPTSNFS ALTRLDQNRA QSMISEKVGT NVDNVHNVII WGNHSQTQVP
260 270 280 290 300
DVNHGYILNY PNRGLIEPIP SSVNDDKWLN EQFIPLVQNR GATVIAARKL
310 320 330 340 350
SSAASAANAI VGHVRDWLLG TKDGEHVSMA VYSDGSYNVP KGLIFSFPVT
360 370 380 390
CHNGQWTIVQ GLKINSSTQQ KIDATIKELQ EEKETAMSFL N
Length:391
Mass (Da):42,265
Last modified:May 24, 2005 - v1
Checksum:iE9433362AD830967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000161 Genomic DNA Translation: EAL62325.1
RefSeqiXP_635832.1, XM_630740.1

Genome annotation databases

EnsemblProtistsiEAL62325; EAL62325; DDB_G0290207
GeneIDi8627540
KEGGiddi:DDB_G0290207

Similar proteinsi

Entry informationi

Entry nameiMDHA_DICDI
AccessioniPrimary (citable) accession number: Q54GE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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