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Q54GE1 (BGAL1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-galactosidase 1

EC=3.2.1.23
Alternative name(s):
Acid beta-galactosidase 1
Short name=Lactase 1
Gene names
Name:glb1
ORF Names:DDB_G0290217
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 671653Beta-galactosidase 1
PRO_0000328062

Sites

Active site2001Proton donor Potential
Active site2881Nucleophile Potential

Amino acid modifications

Glycosylation2281N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4001N-linked (GlcNAc...) Potential
Glycosylation4991N-linked (GlcNAc...) Potential
Glycosylation5091N-linked (GlcNAc...) Potential
Glycosylation5641N-linked (GlcNAc...) Potential
Glycosylation5951N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q54GE1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 27F7DD24EDA31925

FASTA67174,979
        10         20         30         40         50         60 
MKLIVLIFFL LFINLNYCLK IKEQPKVGGI DSEQPTNSFY IENGNFLMNN QGNGGSLNQY 

        70         80         90        100        110        120 
QIISGSFHYF RCLPELWVDR LTKMKACGLN TIQTYIPWNV HQPNGFNTEL VATNDLIEFL 

       130        140        150        160        170        180 
RQAQQIGLNV ILRPGPYSCA EWELGGFPYW ILEQQPIALR SSDSVFISAV IAYWSRLLPL 

       190        200        210        220        230        240 
LEPLLFTNGG PIIMVQVENE YGSYGEDKSY LETLLTLLQK YLGQGDGNGS GVLFHSTDGP 

       250        260        270        280        290        300 
SAQMLFGSKL EGVYQTVDFG PMPIEQIQDN FKIQQTFASK PTPPMNSEYY TGWITNWGDA 

       310        320        330        340        350        360 
SAARTDASVV AQGLDDILSL NASVNMYMFF GGSNAGFMNG ANSNSPTTNF EITIQSYDYD 

       370        380        390        400        410        420 
SPLSESGDTT EKYFAIKNVI EKYIKPTTNS NSTLPPIPSN STKVAYGTIQ ITQATSLFNN 

       430        440        450        460        470        480 
LANLVNSNQQ QLQTGAPIPM EQLQQSTGFV LYETTMNIAQ SSQLSITELH DRATIFINDE 

       490        500        510        520        530        540 
AIEDTQTIGQ AVFLQRPFNS SIEITYPSNV TDDGNFNLRI LLENQGRVNF GPYLNDRKGL 

       550        560        570        580        590        600 
LSGGVLSGQQ YLGPWNNYPL PLTNKTLSNI NNWEQIKDYT LSNTPTFYQA TLSLNSTNDI 

       610        620        630        640        650        660 
GDTFLSFTGL GKGQLFVNGY NVGRYWNVGP QRTIYISSVL LHQGDNEIIL FETLLTQPIF 

       670 
EIQFLNQPYF D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000161 Genomic DNA. Translation: EAL62330.1.
RefSeqXP_635837.1. XM_630745.1.

3D structure databases

ProteinModelPortalQ54GE1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0188784.

Proteomic databases

PRIDEQ54GE1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0266380; DDB0266380; DDB_G0290217.
GeneID8627545.
KEGGddi:DDB_G0290217.

Organism-specific databases

dictyBaseDDB_G0290217. glb1.

Phylogenomic databases

eggNOGCOG1874.
OMAHPEYWED.
PhylomeDBQ54GE1.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFPIRSF006336. B-gal. 1 hit.
PRINTSPR00742. GLHYDRLASE35.
SUPFAMSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGAL1_DICDI
AccessionPrimary (citable) accession number: Q54GE1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase