Beta-galactosidase 1 precursor - Dictyostelium discoideum (Slime mold)

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Q54GE1 (BGAL1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 55. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Beta-galactosidase 1
EC=3.2.1.23

Alternative name(s):
Acid beta-galactosidase 1
Short name=Lactase 1

Gene names

Name:	glb1
ORF Names:	DDB_G0290217

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from direct assay. Source: dictyBase lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-galactosidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

18

Potential

Chain

653

Beta-galactosidase 1

PRO_0000328062

Sites

Active site

1

Proton donor Potential

Active site

1

Nucleophile Potential

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q54GE1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 27F7DD24EDA31925
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671

74,979

        10         20         30         40         50         60 
MKLIVLIFFL LFINLNYCLK IKEQPKVGGI DSEQPTNSFY IENGNFLMNN QGNGGSLNQY 

        70         80         90        100        110        120 
QIISGSFHYF RCLPELWVDR LTKMKACGLN TIQTYIPWNV HQPNGFNTEL VATNDLIEFL 

       130        140        150        160        170        180 
RQAQQIGLNV ILRPGPYSCA EWELGGFPYW ILEQQPIALR SSDSVFISAV IAYWSRLLPL 

       190        200        210        220        230        240 
LEPLLFTNGG PIIMVQVENE YGSYGEDKSY LETLLTLLQK YLGQGDGNGS GVLFHSTDGP 

       250        260        270        280        290        300 
SAQMLFGSKL EGVYQTVDFG PMPIEQIQDN FKIQQTFASK PTPPMNSEYY TGWITNWGDA 

       310        320        330        340        350        360 
SAARTDASVV AQGLDDILSL NASVNMYMFF GGSNAGFMNG ANSNSPTTNF EITIQSYDYD 

       370        380        390        400        410        420 
SPLSESGDTT EKYFAIKNVI EKYIKPTTNS NSTLPPIPSN STKVAYGTIQ ITQATSLFNN 

       430        440        450        460        470        480 
LANLVNSNQQ QLQTGAPIPM EQLQQSTGFV LYETTMNIAQ SSQLSITELH DRATIFINDE 

       490        500        510        520        530        540 
AIEDTQTIGQ AVFLQRPFNS SIEITYPSNV TDDGNFNLRI LLENQGRVNF GPYLNDRKGL 

       550        560        570        580        590        600 
LSGGVLSGQQ YLGPWNNYPL PLTNKTLSNI NNWEQIKDYT LSNTPTFYQA TLSLNSTNDI 

       610        620        630        640        650        660 
GDTFLSFTGL GKGQLFVNGY NVGRYWNVGP QRTIYISSVL LHQGDNEIIL FETLLTQPIF 

       670 
EIQFLNQPYF D

References

[1]

"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.

expand/collapse author list

Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000161 Genomic DNA. Translation: EAL62330.1.
RefSeq	XP_635837.1. XM_630745.1.
3D structure databases
ProteinModelPortal	Q54GE1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54GE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0266380; DDB0266380; DDB_G0290217.
GeneID	8627545.
GenomeReviews	Gene locus glb1 in contig CM000154_GR.
KEGG	ddi:DDB_G0290217.
Organism-specific databases
dictyBase	DDB_G0290217. glb1.
Phylogenomic databases
eggNOG	KOG0496.
GeneTree	EPrGT00050000004828.
HOGENOM	HBG292753.
OMA	MDEAGGV.
PhylomeDB	Q54GE1.
ProtClustDB	CLSZ2429695.
Family and domain databases
InterPro	IPR008979. Galactose-bd-like. IPR019801. Glyco_hydro_35_CS. IPR013781. Glyco_hydro_subgr_catalytic. IPR001944. Glycoside_Hdrlase_35. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K12309.
PANTHER	PTHR23421. Glyco_hydro_35. 1 hit.
Pfam	PF01301. Glyco_hydro_35. 1 hit. [Graphical view]
PRINTS	PR00742. GLHYDRLASE35.
SUPFAM	SSF49785. Gal_bind_like. 1 hit. SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS01182. GLYCOSYL_HYDROL_F35. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BGAL1_DICDI

Accession

Primary (citable) accession number: Q54GE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents