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Q54GE1

- BGAL1_DICDI

UniProt

Q54GE1 - BGAL1_DICDI

Protein

Beta-galactosidase 1

Gene

glb1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei200 – 2001Proton donorSequence Analysis
    Active sitei288 – 2881NucleophileSequence Analysis

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase 1 (EC:3.2.1.23)
    Alternative name(s):
    Acid beta-galactosidase 1
    Short name:
    Lactase 1
    Gene namesi
    Name:glb1
    ORF Names:DDB_G0290217
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0290217. glb1.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 671653Beta-galactosidase 1PRO_0000328062Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi595 – 5951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ54GE1.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0188784.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54GE1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1874.
    KOiK12309.
    OMAiHPEYWED.
    PhylomeDBiQ54GE1.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR026283. B-gal_1-like.
    IPR008979. Galactose-bd-like.
    IPR019801. Glyco_hydro_35_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006336. B-gal. 1 hit.
    PRINTSiPR00742. GLHYDRLASE35.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54GE1-1 [UniParc]FASTAAdd to Basket

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    MKLIVLIFFL LFINLNYCLK IKEQPKVGGI DSEQPTNSFY IENGNFLMNN    50
    QGNGGSLNQY QIISGSFHYF RCLPELWVDR LTKMKACGLN TIQTYIPWNV 100
    HQPNGFNTEL VATNDLIEFL RQAQQIGLNV ILRPGPYSCA EWELGGFPYW 150
    ILEQQPIALR SSDSVFISAV IAYWSRLLPL LEPLLFTNGG PIIMVQVENE 200
    YGSYGEDKSY LETLLTLLQK YLGQGDGNGS GVLFHSTDGP SAQMLFGSKL 250
    EGVYQTVDFG PMPIEQIQDN FKIQQTFASK PTPPMNSEYY TGWITNWGDA 300
    SAARTDASVV AQGLDDILSL NASVNMYMFF GGSNAGFMNG ANSNSPTTNF 350
    EITIQSYDYD SPLSESGDTT EKYFAIKNVI EKYIKPTTNS NSTLPPIPSN 400
    STKVAYGTIQ ITQATSLFNN LANLVNSNQQ QLQTGAPIPM EQLQQSTGFV 450
    LYETTMNIAQ SSQLSITELH DRATIFINDE AIEDTQTIGQ AVFLQRPFNS 500
    SIEITYPSNV TDDGNFNLRI LLENQGRVNF GPYLNDRKGL LSGGVLSGQQ 550
    YLGPWNNYPL PLTNKTLSNI NNWEQIKDYT LSNTPTFYQA TLSLNSTNDI 600
    GDTFLSFTGL GKGQLFVNGY NVGRYWNVGP QRTIYISSVL LHQGDNEIIL 650
    FETLLTQPIF EIQFLNQPYF D 671
    Length:671
    Mass (Da):74,979
    Last modified:May 24, 2005 - v1
    Checksum:i27F7DD24EDA31925
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000161 Genomic DNA. Translation: EAL62330.1.
    RefSeqiXP_635837.1. XM_630745.1.

    Genome annotation databases

    EnsemblProtistsiDDB0266380; DDB0266380; DDB_G0290217.
    GeneIDi8627545.
    KEGGiddi:DDB_G0290217.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000161 Genomic DNA. Translation: EAL62330.1 .
    RefSeqi XP_635837.1. XM_630745.1.

    3D structure databases

    ProteinModelPortali Q54GE1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0188784.

    Proteomic databases

    PRIDEi Q54GE1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0266380 ; DDB0266380 ; DDB_G0290217 .
    GeneIDi 8627545.
    KEGGi ddi:DDB_G0290217.

    Organism-specific databases

    dictyBasei DDB_G0290217. glb1.

    Phylogenomic databases

    eggNOGi COG1874.
    KOi K12309.
    OMAi HPEYWED.
    PhylomeDBi Q54GE1.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR026283. B-gal_1-like.
    IPR008979. Galactose-bd-like.
    IPR019801. Glyco_hydro_35_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006336. B-gal. 1 hit.
    PRINTSi PR00742. GLHYDRLASE35.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiBGAL1_DICDI
    AccessioniPrimary (citable) accession number: Q54GE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3