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Q54GE1

- BGAL1_DICDI

UniProt

Q54GE1 - BGAL1_DICDI

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Protein
Beta-galactosidase 1
Gene
glb1, DDB_G0290217
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei200 – 2001Proton donor Reviewed prediction
Active sitei288 – 2881Nucleophile Reviewed prediction

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase 1 (EC:3.2.1.23)
Alternative name(s):
Acid beta-galactosidase 1
Short name:
Lactase 1
Gene namesi
Name:glb1
ORF Names:DDB_G0290217
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290217. glb1.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 671653Beta-galactosidase 1
PRO_0000328062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi400 – 4001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi564 – 5641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi595 – 5951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ54GE1.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0188784.

Structurei

3D structure databases

ProteinModelPortaliQ54GE1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
KOiK12309.
OMAiHPEYWED.
PhylomeDBiQ54GE1.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54GE1-1 [UniParc]FASTAAdd to Basket

« Hide

MKLIVLIFFL LFINLNYCLK IKEQPKVGGI DSEQPTNSFY IENGNFLMNN    50
QGNGGSLNQY QIISGSFHYF RCLPELWVDR LTKMKACGLN TIQTYIPWNV 100
HQPNGFNTEL VATNDLIEFL RQAQQIGLNV ILRPGPYSCA EWELGGFPYW 150
ILEQQPIALR SSDSVFISAV IAYWSRLLPL LEPLLFTNGG PIIMVQVENE 200
YGSYGEDKSY LETLLTLLQK YLGQGDGNGS GVLFHSTDGP SAQMLFGSKL 250
EGVYQTVDFG PMPIEQIQDN FKIQQTFASK PTPPMNSEYY TGWITNWGDA 300
SAARTDASVV AQGLDDILSL NASVNMYMFF GGSNAGFMNG ANSNSPTTNF 350
EITIQSYDYD SPLSESGDTT EKYFAIKNVI EKYIKPTTNS NSTLPPIPSN 400
STKVAYGTIQ ITQATSLFNN LANLVNSNQQ QLQTGAPIPM EQLQQSTGFV 450
LYETTMNIAQ SSQLSITELH DRATIFINDE AIEDTQTIGQ AVFLQRPFNS 500
SIEITYPSNV TDDGNFNLRI LLENQGRVNF GPYLNDRKGL LSGGVLSGQQ 550
YLGPWNNYPL PLTNKTLSNI NNWEQIKDYT LSNTPTFYQA TLSLNSTNDI 600
GDTFLSFTGL GKGQLFVNGY NVGRYWNVGP QRTIYISSVL LHQGDNEIIL 650
FETLLTQPIF EIQFLNQPYF D 671
Length:671
Mass (Da):74,979
Last modified:May 24, 2005 - v1
Checksum:i27F7DD24EDA31925
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000161 Genomic DNA. Translation: EAL62330.1.
RefSeqiXP_635837.1. XM_630745.1.

Genome annotation databases

EnsemblProtistsiDDB0266380; DDB0266380; DDB_G0290217.
GeneIDi8627545.
KEGGiddi:DDB_G0290217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000161 Genomic DNA. Translation: EAL62330.1 .
RefSeqi XP_635837.1. XM_630745.1.

3D structure databases

ProteinModelPortali Q54GE1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0188784.

Proteomic databases

PRIDEi Q54GE1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0266380 ; DDB0266380 ; DDB_G0290217 .
GeneIDi 8627545.
KEGGi ddi:DDB_G0290217.

Organism-specific databases

dictyBasei DDB_G0290217. glb1.

Phylogenomic databases

eggNOGi COG1874.
KOi K12309.
OMAi HPEYWED.
PhylomeDBi Q54GE1.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PIRSFi PIRSF006336. B-gal. 1 hit.
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiBGAL1_DICDI
AccessioniPrimary (citable) accession number: Q54GE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3