Q54GC8 (ACBD6_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA-binding domain-containing protein 6 homolog

Gene names

Name:	acbd6
ORF Names:	DDB_G0290237

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA. Does not bind fatty acids By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 ACB (acyl-CoA-binding) domain. Contains 2 ANK repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fatty-acyl-CoA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Acyl-CoA-binding domain-containing protein 6 homolog		PRO_0000328232
Regions
	Domain	6 – 94	89	ACB
	Repeat	200 – 229	30	ANK 1
	Repeat	233 – 263	31	ANK 2

Sequences

	Sequence		Length	Mass (Da)
	Q54GC8 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: AE9647B662CAD7F5	FASTA	288	32,891
	10 20 30 40 50 60 MTDAQIENKF KLAVDYITNN SGKLSNIKNE EQLYLYCNYK QATIGDCNTK APPFYDYIGK 70 80 90 100 110 120 SKWNSWNSLK GVEKIVAMNS YISLVNALSP GWDSNIKVER ATQSVFLNDE EFKELEKKEK 130 140 150 160 170 180 EEKEELKKLE EENGGEIEKP KSKWMGPVLS KFSLVDDETL EKLEKNTKQD LGYWVSVNDI 190 200 210 220 230 240 ERVKKEIEND KNIINEVDED GRTALIWACD RGYFEIAKLL IENGSNVNVQ DGEGMTPLHY 250 260 270 280 AVVCDQFEIC KLLLSQSSID KSIKDNSDSI PSDFIDSSTS ENIKSLFK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000161 Genomic DNA. Translation: EAL62340.1.
RefSeq	XP_635850.1. XM_630758.1.
3D structure databases
HSSP	HSSP built from PDB template 2CQU based on UniProtKB O75521.
ProteinModelPortal	Q54GC8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0266382; DDB0266382; DDB_G0290237.
GeneID	8627558.
GenomeReviews	Gene locus acbd6 in contig CM000154_GR.
KEGG	ddi:DDB_G0290237.
Organism-specific databases
dictyBase	DDB_G0290237. acbd6.
Phylogenomic databases
eggNOG	KOG0817.
GeneTree	EPrGT00050000002179.
HOGENOM	HBG596574.
OMA	KVERATQ.
PhylomeDB	Q54GC8.
Family and domain databases
InterPro	IPR000582. Acyl-CoA-binding_protein. IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. [Graphical view]
Gene3D	G3DSA:1.20.80.10. ACBP. 1 hit. G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00887. ACBP. 1 hit. PF12796. Ank_2. 1 hit. [Graphical view]
PRINTS	PR00689. ACOABINDINGP.
SMART	SM00248. ANK. 2 hits. [Graphical view]
SUPFAM	SSF47027. ACBP. 1 hit. SSF48403. ANK. 1 hit.
PROSITE	PS00880. ACB_1. False negative. PS51228. ACB_2. 1 hit. PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACBD6_DICDI

Accession

Primary (citable) accession number: Q54GC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	October 19, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)