Q54GA9 (MGST_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable microsomal glutathione S-transferase
EC=2.5.1.18

Gene names

Name:	mgst
ORF Names:	DDB_G0290291

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May perform the conjugation of reduced glutathione to electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the MAPEG family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione biosynthetic process Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	endoplasmic reticulum Inferred from Biological aspect of Ancestor. Source: RefGenome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	glutathione peroxidase activity Inferred from Biological aspect of Ancestor. Source: RefGenome glutathione transferase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 149	149	Probable microsomal glutathione S-transferase		PRO_0000331235
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	123 – 143	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q54GA9 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: FB822FF2A2C7818A	FASTA	149	16,626
	10 20 30 40 50 60 MPFDTKSIFP DFIVFPSAIS TIAIGLWSVQ AYKLGEARKR YNVKAPHVQG DPEFERIAHE 70 80 90 100 110 120 YQNTSEALGA IIPATFMFSY YISPKCSLLL GGTWLVSKML NCCSYCCKKE KENDCAKNVH 130 140 TCLSHISFFA LLGGSAFGIG SSLYNRYKL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000162 Genomic DNA. Translation: EAL62272.1.
RefSeq	XP_635774.1. XM_630682.1.
3D structure databases
ProteinModelPortal	Q54GA9.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0231516.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231516; DDB0231516; DDB_G0290291.
GeneID	8627578.
KEGG	ddi:DDB_G0290291.
Organism-specific databases
dictyBase	DDB_G0290291.
Phylogenomic databases
eggNOG	NOG77136.
KO	K00799.
OMA	EYQNTSE.
Family and domain databases
Gene3D	1.20.120.550. 1 hit.
InterPro	IPR023352. MAPEG-like_dom. IPR001129. Membr-assoc_MAPEG. [Graphical view]
Pfam	PF01124. MAPEG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MGST_DICDI

Accession

Primary (citable) accession number: Q54GA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)