Q54G06 (XPP1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xaa-Pro aminopeptidase 1
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Cytosolic aminopeptidase P
Soluble aminopeptidase P
Short name=sAmp
X-Pro aminopeptidase 1
X-prolyl aminopeptidase 1, soluble

Gene names

Name:	xpnpep1
Synonyms:	xpnpepl, xpnpepl1
ORF Names:	DDB_G0290501

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	627 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bradykinin catabolic process Inferred from sequence or structural similarity. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	manganese ion binding Inferred from sequence or structural similarity. Source: UniProtKB metalloaminopeptidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 627	627	Xaa-Pro aminopeptidase 1		PRO_0000328258
Sites
	Metal binding	424	1	Manganese 1 By similarity
	Metal binding	435	1	Manganese 1 By similarity
	Metal binding	435	1	Manganese 2 By similarity
	Metal binding	498	1	Manganese 2 By similarity
	Metal binding	533	1	Manganese 2 By similarity
	Metal binding	547	1	Manganese 1 By similarity
	Metal binding	547	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54G06 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: B5EEE1505557CA8A	FASTA	627	71,393
	10 20 30 40 50 60 MQRVLNKIIS KDTINTMGKV AISKKVEKLR TFMKDQSLSA YIVPSEDAHQ SEYICVKDKR 70 80 90 100 110 120 REYISGFSGS AGCVVITLDN QLLWTDGRYW LQAEKELESN WKIMKDRVVG EPTIQDWLLS 130 140 150 160 170 180 NLNKENKVGI DSRLISKGYY DSMKLVLKEK SIDIKFDEDG ENLIDKVRES FKDEEEIPEY 190 200 210 220 230 240 PKNSIFFLED KFTGKQSNEK LKEIREEMKK QSADLMVVSA LDEIAWLLNL RGSDISFNPV 250 260 270 280 290 300 FLSYVVVEHE KVTLFVDESK LNDKTKSQLP SGIAISPYSS VFEYLRNSDK QGKKIWIDPR 310 320 330 340 350 360 SSVALYNCVS ISNLLEKINP ILLSKAIKNE TEIQGMKNAH IRDAVALIQF LAWMEEEIVE 370 380 390 400 410 420 KSDETSHTEY SVCEKLEGFR RQQTDFVSLS FDTISSINAN GAIIHYKPDE TTSATIVKGM 430 440 450 460 470 480 YLVDSGAQYL DGTTDVTRTL HYGKPTQHEI DCYTRVLRGH VGLSLLKFPN RVNGRDIDCV 490 500 510 520 530 540 ARTHLWSVGL DYAHGTGHGV GSFLNVHEGP QGISYRAIAN PTNLQAGMTL TNEPGYYESG 550 560 570 580 590 600 NFGIRIENVM IVAPVTTQFN NGKFIGFDNI TLVPYERKLI NLEMLTKDEI NFINDYYKEI 610 620 GEKILPLIEK TNNQKSINWL KNQIKPL

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000164 Genomic DNA. Translation: EAL62111.1.
RefSeq	XP_635611.1. XM_630519.1.
3D structure databases
ProteinModelPortal	Q54G06.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDBDRAFT_0188915.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0304433; DDB0304433; DDB_G0290501.
GeneID	8627683.
KEGG	ddi:DDB_G0290501.
Organism-specific databases
dictyBase	DDB_G0290501. xpnpep1.
Phylogenomic databases
eggNOG	COG0006.
KO	K01262.
OMA	SRYWEQA.
ProtClustDB	CLSZ2444208.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 2 hits. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XPP1_DICDI

Accession

Primary (citable) accession number: Q54G06

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)