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Protein

Mitochondrial substrate carrier family protein W

Gene

mcfW

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein W
Gene namesi
Name:mcfW
ORF Names:DDB_G0290669
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290669. mcfW.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39Mitochondrial intermembraneBy similarityAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 90Mitochondrial matrixBy similarityAdd BLAST30
Transmembranei91 – 111Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini112 – 135Mitochondrial intermembraneBy similarityAdd BLAST24
Transmembranei136 – 156Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini157 – 193Mitochondrial matrixBy similarityAdd BLAST37
Transmembranei194 – 214Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini215 – 230Mitochondrial intermembraneBy similarityAdd BLAST16
Transmembranei231 – 251Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini252 – 296Mitochondrial matrixBy similarityAdd BLAST45
Transmembranei297 – 315Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini316 – 329Mitochondrial intermembraneBy similarityAdd BLAST14

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003855291 – 329Mitochondrial substrate carrier family protein WAdd BLAST329

Proteomic databases

PaxDbiQ54FU9.

Structurei

3D structure databases

ProteinModelPortaliQ54FU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 119Solcar 1Add BLAST86
Repeati133 – 221Solcar 2Add BLAST89
Repeati231 – 321Solcar 3Add BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 26Poly-Gln9

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0757. Eukaryota.
ENOG410XS20. LUCA.
InParanoidiQ54FU9.
KOiK15115.
OMAiTHVAVQF.
PhylomeDBiQ54FU9.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q54FU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNNSNDNN KRYGIIKQQL QQQQQQHHQQ HEQHSRLVEM TAGCGAGFMA
60 70 80 90 100
SLFTTPLDVI KTTLQVDNSS NKTIMSTVKS ILDRKGGVKN LYLGLKPTLV
110 120 130 140 150
GQIPSWAVYF STYTFCKELF TKENDKHSLL EKESPLIFMT SAIIAGAATS
160 170 180 190 200
ICTSPIWLIK TRFITQEMVG RQKKYRGIVH SMVSIYHEEG FRGLYKGLGP
210 220 230 240 250
SLLGVLHVGV QFPLYEKFKS ILKEKNKNKE LGIVEIMIAS SVSKIIASVV
260 270 280 290 300
AYPHEVLRAR SQDSSPDSPN RTYRGNIIQM FKQIVREEGW RGLYRGMGVN
310 320
LLRVTPSCVI TFTSYEYIKK FLSQNQNHF
Length:329
Mass (Da):37,321
Last modified:May 24, 2005 - v1
Checksum:i6B5134E2DE130788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000164 Genomic DNA. Translation: EAL62195.1.
RefSeqiXP_635668.1. XM_630576.1.

Genome annotation databases

EnsemblProtistsiEAL62195; EAL62195; DDB_G0290669.
GeneIDi8627740.
KEGGiddi:DDB_G0290669.

Similar proteinsi

Entry informationi

Entry nameiMCFW_DICDI
AccessioniPrimary (citable) accession number: Q54FU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families