Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable polyketide synthase 30

Gene

pks30

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable polyketide synthase (By similarity). May be involved in the process of cell migration.By similarity1 Publication

Miscellaneous

Encoded by one of the numerous copies of polyketide synthase genes and clustered as a quartet pks29/pks30/pks31/pks32 in chromosome 5.

Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei198For beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei673For acyl/malonyl transferase activityPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cell motility Source: dictyBase

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-DDI-163765 ChREBP activates metabolic gene expression
R-DDI-199220 Vitamin B5 (pantothenate) metabolism
R-DDI-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable polyketide synthase 30 (EC:2.3.1.-)
Short name:
dipks30
Gene namesi
Name:pks30
ORF Names:DDB_G0290701
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290701 pks30

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003713901 – 3075Probable polyketide synthase 30Add BLAST3075

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2570O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiQ54FQ2
PRIDEiQ54FQ2

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235263

Structurei

3D structure databases

ProteinModelPortaliQ54FQ2
SMRiQ54FQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2533 – 2610CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 232Beta-ketoacyl synthaseAdd BLAST54
Regioni663 – 696Acyl/malonyl transferaseAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi199 – 202Poly-Ser4
Compositional biasi881 – 938Asn-richAdd BLAST58
Compositional biasi1160 – 1165Poly-Asn6
Compositional biasi1207 – 1214Poly-Asn8
Compositional biasi1683 – 1688Poly-Asn6
Compositional biasi2525 – 2528Poly-Ser4
Compositional biasi2612 – 2624Poly-AsnAdd BLAST13
Compositional biasi2659 – 2663Poly-Asn5

Domaini

Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity

Phylogenomic databases

eggNOGiKOG1202 Eukaryota
COG3321 LUCA
InParanoidiQ54FQ2
OMAiDITVQMV
PhylomeDBiQ54FQ2

Family and domain databases

CDDicd05235 SDR_e1, 1 hit
Gene3Di1.10.1200.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR010080 Thioester_reductase-like_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08240 ADH_N, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF08242 Methyltransf_12, 1 hit
PF07993 NAD_binding_4, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 4 hits
SSF52151 SSF52151, 2 hits
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit

Sequencei

Sequence statusi: Complete.

Q54FQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQNTDNNTY NQLIRDINDY DDAGSSGDVA VIGIGLRFPS GSLKESISKP
60 70 80 90 100
NQLFNELLNG LDGIVTTSER WSDNYFLNGE IASKFAGLLP LDEWKQFDPI
110 120 130 140 150
FFAINPSNDN VSSIDPQQRF LLKCVWEALE DSGIDPISLR GTNTSTFIGS
160 170 180 190 200
STIDYNNLQK SSFETQNNIF GSSTHSVANR IGYCFDFRGE NLTIDTACSS
210 220 230 240 250
SSNAINCGYN SIKSNKSNVS IVGGVNFILD PHISKSFTQL GLLSPTGRCH
260 270 280 290 300
TFSSDADGYV RSEGVGIVVL KKLKDAIKDS NNIYCVIKGS SSNIDGNFDK
310 320 330 340 350
LNFYSPSKSS QYENIKLAIK STNGQINESD IDYCETHGTG TPTGDPIELE
360 370 380 390 400
GISRVFNKAP ATTNNNHKQV LIGSIKSNIG HTEACSGVAS LIKCCLMFKN
410 420 430 440 450
KLFLQNINFK EPNPLINFKE WGLKVVTEPI KFNENKSTVM LINNFGVTGS
460 470 480 490 500
NVCLILSEFK NNLSRYGNGN GYHKMEIDNN LNEKKKYLIP LSSNSSTSLN
510 520 530 540 550
NYKSSIIKHS NSNSSPTTTS FKEFVYNQIK FKSTSLIQKS VIIASDWNEF
560 570 580 590 600
QDESNQIKLN NSDNLISNIT VEKKKSPITV MVLCGQGSQY NKMALSLYDN
610 620 630 640 650
EPIFRESVNR FDKELFKYYG YSVLDKLRSI DDKDLISIHQ PILAQPANVI
660 670 680 690 700
IQVSLYELYK HWGVSADIII GHSLGEVSSP YCSGMIDFQT LCYLTYHRSV
710 720 730 740 750
AQNRTTGTGR MLSVNISSDE FINKYQSTTK YKSLEIACYN SPTSIVIAGN
760 770 780 790 800
EDLLNEITNE FKSNDIFCSM LGSLSSFHTS SQQMIKDEVC SLNISSKQPS
810 820 830 840 850
IAVFSTVTTN LFNHQTSPFN ANYVFDNIIQ PVYFTQTITN LYKHIESNDM
860 870 880 890 900
GNEITFIEVS PHPTLQYYLN QMKSTQSSYF NNGKNITIYS PLNKKKNDYN
910 920 930 940 950
EFLKTISLLY VNNNFDINFK SQLINDNNNI SNTTKLNNLP LYQWDDKEYF
960 970 980 990 1000
KLNSSLEKIK SEGPSINNLG NNTDSPYLSY QTFIDIKKSP FQWLKGHQVS
1010 1020 1030 1040 1050
DKFYYPGMGY VHNLLSIYPN QDITISSLEF KSPLVLTEGN NQCLQTIIAP
1060 1070 1080 1090 1100
LSKNEFNIKS HYKDQKTNQW ILSSLGNFSL TKHNSITSNK LINIQSLKDK
1110 1120 1130 1140 1150
CNFTSMSKQD FYETIRIKTN LTYKGLFQGV KQCYIGNNCS LAIVSLNEIY
1160 1170 1180 1190 1200
NQKEYNHLIN NNNMNTFFNA AILDTCLHGS LVAVTQPVVL DKIEAFKFYS
1210 1220 1230 1240 1250
SNIPLLNKNN NNNNSDDDSI KELYVFSDIK PRTNSQTYSV SVKVILPNGT
1260 1270 1280 1290 1300
LLVDISNVVC ALVSLGSNPD STIICKPPSN DIYTPYLQLK DSIINKPEQF
1310 1320 1330 1340 1350
KHLYSVDEFS VKEEDNQFIS NELLLSLFYK HINNRSPSIN LESLTTLEYN
1360 1370 1380 1390 1400
QFKQLYYNSL ANENLFKFIF ENLKRYSNIL NHDNNHSNIK SKHEELYIRT
1410 1420 1430 1440 1450
TKIMAKQLFP LKDDDSITDT PQSLFESGFL DDFYKNSRVV QPLNNLLSEI
1460 1470 1480 1490 1500
IVETLKPILN EPIVFRILEA GGGTGSLSLL ILEKICKLLN DNSTTSIINI
1510 1520 1530 1540 1550
EFTWSDVSAS FFAEIKEKFS SFTNHNNLNI IYRVLDLEKP LLDQDLKASY
1560 1570 1580 1590 1600
YDFIVMSNVM HVVKKLKPTL NEIHNILTPN GQLLYIEPPY KSFYYDSIFG
1610 1620 1630 1640 1650
CFSQWWPSSD SDIELRPDRC CMKQEKWINL LNQCNYRDTI MSGNDNLLFL
1660 1670 1680 1690 1700
IQTRKPTINE IISEQSISLD QLNSFNNIIL FCNNNNSNDK NRNSCSSSIL
1710 1720 1730 1740 1750
DLIRSNQELK HKIININNYN EFQSWITNNQ NKDDCNKTLI IFLKSIESTM
1760 1770 1780 1790 1800
NTFNFKEITF EYIQINQLIL KLELSNNFKH LLLSLNSSTD NYLSSSIIGA
1810 1820 1830 1840 1850
ARYFVEFPQL DLYILNYDNV SIENNQQLSL INYLINPNNN IQKEFTINNN
1860 1870 1880 1890 1900
KVYYERYCRR SNNIKSIFQS ESFETNKDNL YIQLNSNLEY QLYSKKAELN
1910 1920 1930 1940 1950
SNEVEIEVKA NGINYKDYLM YIGMIGTDLD IKYGKEYEIE NGIGIDNPNI
1960 1970 1980 1990 2000
GNDFSGIITR LGSNVKKFKV GDQVCGIGSK TNSSHVIIDF NFIYYKPLNY
2010 2020 2030 2040 2050
NHSVSASIPS IYITSLHSIY SIGNLKSNES ILIHSAAGGV GISSLDLLKS
2060 2070 2080 2090 2100
KQHQGYIFLT VGSKDKEEYL TKKYGSLITA IYSSRNKDYV YEIKNKLIEL
2110 2120 2130 2140 2150
GVVEQNQQGV DIILNTLSSE YMDSNFQCLN MSGCIVDLSI THLTPNDYMT
2160 2170 2180 2190 2200
NNHYKFNMGY NNVEVVDFPS KLIKSYLKKI IKMINSNELE LSVPIIEYSN
2210 2220 2230 2240 2250
NQFKDAIEYI NQRKHIGKII VNHNQDEFNR VYNNYQSNNN QIIMKHSYDI
2260 2270 2280 2290 2300
SKLNIGKNIL LTGQTGIVLE ILKYLVKYSN HSIENIIILS KSKLKWELEL
2310 2320 2330 2340 2350
LINQSKFKKD NNIKFHFNQI DIEDSNKVNQ VLNQLELNEN ITNIDSIIHF
2360 2370 2380 2390 2400
AFMNDIGDVQ QVDMNRLNNA HGAKTIGAIN LHNQSINRSW NIKQFIMASS
2410 2420 2430 2440 2450
IVSIFGSDQQ CCYVSACSVI DSLSKYRHSI GLPSLAINLG AISSTGFISR
2460 2470 2480 2490 2500
NNAIETMFKS SILKLFSPQL VISSLDLFIQ NQHQYPNYCL SDFNFEVLPS
2510 2520 2530 2540 2550
TLTNHFLTKF DYQINISKKL SQIKSSSSGN GGDNNEIIRS TILNKICELL
2560 2570 2580 2590 2600
SIDESKINED LQLTQYGMDS LVIVQLKNFI DNQIGHNLIT IQQLQNNKIN
2610 2620 2630 2640 2650
QSIEIIKSAH INNNKNKNNN NNNNLVKKEQ QSLDEFIKNE IKLNESIISR
2660 2670 2680 2690 2700
PYSIKNILNN NNNKSIFLTG STGFLGAYLL TELIKMDNIS KIYCLIRNNS
2710 2720 2730 2740 2750
KLTNPIDVII NNLKKHQLID MNKESPNQRL TKIINRTGNM SNDKLNSNIE
2760 2770 2780 2790 2800
NSENNNKQIS EDQLIKIIPM IGDVSKDKFG LTEQDYLKLS NECDIIINSA
2810 2820 2830 2840 2850
ADLNLKSNYE ESKTVNVDSI NQVIKLSVSN NSSQKLIVHF SSIAVFINHQ
2860 2870 2880 2890 2900
LKDGETFEET NILPNFYTTP IGYIQCKVIS EKLLTNAAES RGIPSIIIRP
2910 2920 2930 2940 2950
PDIFSNPITG IGHSNDFVSL LLKVSKEIGY YPNIHKPIFT TPITTIAKTT
2960 2970 2980 2990 3000
IDLIFNENSW NQNKSKPISI YSLNGNSIEM KSIYEFLENK FNCKEIDYQE
3010 3020 3030 3040 3050
WIKLVSKSNG KSSKRYSAFH IHDNQNLLIS TFKINSLFKM SNSTKELLIS
3060 3070
IGSYNHQDWE INESIILNNI NSNSN
Length:3,075
Mass (Da):349,549
Last modified:May 24, 2005 - v1
Checksum:i034D04EA30186AD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000167 Genomic DNA Translation: EAL62085.1
RefSeqiXP_635589.1, XM_630497.1

Genome annotation databases

EnsemblProtistsiEAL62085; EAL62085; DDB_G0290701
GeneIDi8627786
KEGGiddi:DDB_G0290701

Similar proteinsi

Entry informationi

Entry nameiPKS30_DICDI
AccessioniPrimary (citable) accession number: Q54FQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health