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Protein

Mitochondrial substrate carrier family protein S

Gene

mcfS

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-DDI-70635. Urea cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein S
Alternative name(s):
Carnitine/acylcarnitine translocase
Short name:
CAC
Solute carrier family 25 member 20 homolog B
Gene namesi
Name:mcfS
Synonyms:slc25a20B
ORF Names:DDB_G0290913
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290913. mcfS.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Mitochondrial intermembraneBy similarity9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 61Mitochondrial matrixBy similarityAdd BLAST31
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 101Mitochondrial intermembraneBy similarityAdd BLAST19
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 150Mitochondrial matrixBy similarityAdd BLAST28
Transmembranei151 – 172Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini173 – 199Mitochondrial intermembraneBy similarityAdd BLAST27
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 258Mitochondrial matrixBy similarityAdd BLAST38
Transmembranei259 – 277Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini278 – 285Mitochondrial intermembraneBy similarity8

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003855261 – 285Mitochondrial substrate carrier family protein SAdd BLAST285

Proteomic databases

PaxDbiQ54FE6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0234097.

Structurei

3D structure databases

ProteinModelPortaliQ54FE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 87Solcar 1Add BLAST84
Repeati96 – 183Solcar 2Add BLAST88
Repeati197 – 283Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
InParanoidiQ54FE6.
KOiK15109.
OMAiGVCVSIQ.
PhylomeDBiQ54FE6.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q54FE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTERGLKDS IAGTVAGAAC LFTGHPFDTI RVRLQTSNTP IGIMECFRNT
60 70 80 90 100
IKYEGFSGLY KGVTSPLFGM MFETAVLFAG YGQMKVLLQK DENTPLTVGQ
110 120 130 140 150
CAIAGGFAGV GASVVLTPVE LVKCRLQVQT TGPQKYKGSL DCLVQILKEG
160 170 180 190 200
GIRGAYRGFT PTIAREFVGN MAFFSTYETC KRYFKNKENK PNDDDELNLP
210 220 230 240 250
ALIISGGLGG MAYWTVLYPV DVAKSKIQIS EGAGPSPSIV KVLKEIYSKE
260 270 280
GVKGLFRGYT PTIIRSFPAN AAMFSVYELV IKLLG
Length:285
Mass (Da):30,869
Last modified:May 24, 2005 - v1
Checksum:i1B556CA74591B004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000172 Genomic DNA. Translation: EAL61972.1.
RefSeqiXP_635476.1. XM_630384.1.

Genome annotation databases

EnsemblProtistsiEAL61972; EAL61972; DDB_G0290913.
GeneIDi8627892.
KEGGiddi:DDB_G0290913.

Similar proteinsi

Entry informationi

Entry nameiMCFS_DICDI
AccessioniPrimary (citable) accession number: Q54FE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 24, 2005
Last modified: July 5, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families