Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Xanthine dehydrogenase

Gene

xdh

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity).By similarity

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 2 [2Fe-2S] clusters.By similarity
  • FADBy similarity
  • Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Iron-sulfur 1By similarity1
Metal bindingi61Iron-sulfur 1By similarity1
Metal bindingi64Iron-sulfur 1By similarity1
Metal bindingi89Iron-sulfur 1By similarity1
Metal bindingi129Iron-sulfur 2By similarity1
Metal bindingi132Iron-sulfur 2By similarity1
Metal bindingi164Iron-sulfur 2By similarity1
Metal bindingi166Iron-sulfur 2By similarity1
Binding sitei366FADBy similarity1
Binding sitei389FADBy similarity1
Binding sitei437FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei455FADBy similarity1
Metal bindingi805MolybdenumBy similarity1
Metal bindingi836Molybdenum; via carbonyl oxygenBy similarity1
Binding sitei840SubstrateBy similarity1
Binding sitei918SubstrateBy similarity1
Metal bindingi950Molybdenum; via amide nitrogenBy similarity1
Binding sitei952SubstrateBy similarity1
Binding sitei1048Substrate; via amide nitrogenBy similarity1
Metal bindingi1117Molybdenum; via amide nitrogenBy similarity1
Active sitei1302Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi281 – 288FADBy similarity8
Nucleotide bindingi376 – 380FADBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

ReactomeiR-DDI-74259 Purine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase (EC:1.17.1.4)
Short name:
XD
Gene namesi
Name:xdh
ORF Names:DDB_G0291047
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291047 xdh

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276501 – 1358Xanthine dehydrogenaseAdd BLAST1358

Proteomic databases

PaxDbiQ54FB7
PRIDEiQ54FB7

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230176

Structurei

3D structure databases

ProteinModelPortaliQ54FB7
SMRiQ54FB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 1072Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST90
Domaini253 – 447FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST195

Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG0430 Eukaryota
COG4630 LUCA
COG4631 LUCA
InParanoidiQ54FB7
KOiK00106
OMAiKPEDGEM
PhylomeDBiQ54FB7

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR002888 2Fe-2S-bd
IPR036884 2Fe-2S-bd_dom_sf
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR016208 Ald_Oxase/xanthine_DH
IPR008274 AldOxase/xan_DH_Mopterin-bd
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
IPR005107 CO_DH_flav_C
IPR036683 CO_DH_flav_C_dom_sf
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR002346 Mopterin_DH_FAD-bd
PfamiView protein in Pfam
PF01315 Ald_Xan_dh_C, 1 hit
PF02738 Ald_Xan_dh_C2, 1 hit
PF03450 CO_deh_flav_C, 1 hit
PF00941 FAD_binding_5, 1 hit
PF00111 Fer2, 1 hit
PF01799 Fer2_2, 1 hit
PIRSFiPIRSF000127 Xanthine_DH, 1 hit
SMARTiView protein in SMART
SM01008 Ald_Xan_dh_C, 1 hit
SM01092 CO_deh_flav_C, 1 hit
SUPFAMiSSF47741 SSF47741, 1 hit
SSF54292 SSF54292, 1 hit
SSF54665 SSF54665, 1 hit
SSF55447 SSF55447, 1 hit
SSF56003 SSF56003, 1 hit
SSF56176 SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q54FB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDDENLNGK EPFLKKENQL LFFLNGEKVL INEPNPELST LDYIRSIGLT
60 70 80 90 100
GLKRGCSEGA CGSCTFMLSN VVKDDNDTFR IVHRAVNGCL YPLCALDGMA
110 120 130 140 150
VTTIEGLGNI DKGLHSIQER ISENSGSQCG FCTPGIIMAL YAFLRSNPNS
160 170 180 190 200
TQKDIEQNFD GNLCRCTGYR PILDAAKSFA NQPSDEQLVE LPLPPMATID
210 220 230 240 250
DKKDDTQMIC PGTGKPCNCK TKTSHIPNKP MELNSEPIFP PFLMEYKKES
260 270 280 290 300
LKFTGSRVTW YTPTTLEELL KIKKEKTNAK IVVGNTEIGI ETRFRSIVYP
310 320 330 340 350
TIICPTRVEE LIQIQKEDNG VRVGASVTLT EMKSYLNGII KSSENDEIAN
360 370 380 390 400
KKNGTFKAII SQLKWFAGNQ VRNAASIGGN LCTASPISDL NPVLLAAGAV
410 420 430 440 450
LTMVSLDDNG AKVRRQVPIN QFFLRYRVVD IKPEEILESV FIPYTRPLEF
460 470 480 490 500
IQAYKQSRRR EDDIAIVSCC FRVLLEPIAE SASNTVDSNF KIKDCVLAYG
510 520 530 540 550
GMNVKAVTCE KTEKQLIGSV WSRELLNDAC LNLESDLPLA AGAPGGMIEY
560 570 580 590 600
RRSLTTGFFF KYFLTVSKQL YQISNGNPLY LVSDKEKSAT DAYSRPLSFG
610 620 630 640 650
EQNYQTQPDK HPITQPIKHQ SADKQVTGEA LYVDDVKMKS LYAVMVPSLK
660 670 680 690 700
AHANIKSVDA SKALKAPGVK AFFSAKDIPG INDCGPVIHD EEVFVTKTAL
710 720 730 740 750
FHGAPIGCIV AETHIQALEA SKLVAIEYEE LPAITSIEDA ISKQSFFPFT
760 770 780 790 800
HLLKDGDMEK GWSESDHIID GEFKVGAQEH FYLEPNGTLV IPGEGKELTV
810 820 830 840 850
ISSTQNPTKT QAIVASVLGI GQNQVVCKLK RLGGGFGGKE TRSIFSSCVA
860 870 880 890 900
AIASYHMKEP VRIILDRDTD MSTTGTRHPF IARYRVGFTK EGLIKALDLE
910 920 930 940 950
LYADAGFSYD ISVGVLDRAI FHSENSYKIP NVNILGRLCK TNLPSNTAFR
960 970 980 990 1000
GYGGPQAMII CENWVEKISK TLGMDSYKIR ELNFYKEAEV TAYRQSVVNN
1010 1020 1030 1040 1050
MMKRVWDELM VKSNYHQRLI AVEKFNKENR YKKRGISIIP TKFGMSFTVK
1060 1070 1080 1090 1100
TLNQAGALVH VYTDGTILVT HGGTEMGQGL NTKMIQIAAR AFNVPVSDVF
1110 1120 1130 1140 1150
ISETSTDKVP NTAPTAASVS SDLNGMAVLD ACQQILLRME PIREKNPNVP
1160 1170 1180 1190 1200
FKQLCTLCFV ERVNLSANGF YATPNVGYMF KDSGVGEGTP FNYFNFGAAC
1210 1220 1230 1240 1250
SEVEIDTLTG DHTTLRSDVI LDVGDSLNPT IDIGQVEGAF VQGMGWSTLE
1260 1270 1280 1290 1300
EVVTFPSGYM FTRGPSTYKI PGFNDVPIEF NVSLLGDAPN PKAIHSSKGV
1310 1320 1330 1340 1350
GEPPLFLGSS VYFAIRQAIT AARLENNLTN WFDLQSPATC ERIRTSCLDN

FVLQFRKQ
Length:1,358
Mass (Da):149,928
Last modified:May 24, 2005 - v1
Checksum:iAF9AEE1059FE076F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000174 Genomic DNA Translation: EAL61954.1
RefSeqiXP_635420.1, XM_630328.1

Genome annotation databases

EnsemblProtistsiEAL61954; EAL61954; DDB_G0291047
GeneIDi8627921
KEGGiddi:DDB_G0291047

Similar proteinsi

Entry informationi

Entry nameiXDH_DICDI
AccessioniPrimary (citable) accession number: Q54FB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health