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Protein

Probable copper chaperone for superoxide dismutase

Gene

ccs

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Delivers copper to copper zinc superoxide dismutases.By similarity

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Copper 1Sequence analysis1
Metal bindingi21Copper 1Sequence analysis1
Metal bindingi308Copper 2By similarity1
Metal bindingi310Copper 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable copper chaperone for superoxide dismutase
Alternative name(s):
Superoxide dismutase copper chaperone
Gene namesi
Name:ccs
Synonyms:ccsA
ORF Names:DDB_G0291031
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291031. ccs.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294001 – 316Probable copper chaperone for superoxide dismutaseAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi169 ↔ 291By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ54F73.

Interactioni

Subunit structurei

Homodimer, and heterodimer with SOD1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ54F73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 72HMAAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 298Superoxide dismutase-likeAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi78 – 84Poly-Thr7
Compositional biasi182 – 210Poly-AsnAdd BLAST29
Compositional biasi268 – 275Poly-Asn8

Sequence similaritiesi

In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.Curated
Contains 1 HMA domain.Curated

Phylogenomic databases

InParanoidiQ54F73.
KOiK04569.
OMAiADTHKES.
PhylomeDBiQ54F73.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.60.40.200. 2 hits.
InterProiIPR006121. HMA_dom.
IPR024134. SOD_Cu/Zn_/chaperone.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 3 hits.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 2 hits.
SSF55008. SSF55008. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54F73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDKNLEIKV ELNVDISCQS CVDSISKELR EKLENTKLVE HDIPEQRIVL
60 70 80 90 100
QGTDLTQDIL ETIKNTGRNA TICGLSSTTT TTSTSPSSST CHKKQETVSG
110 120 130 140 150
SAVCSLGLIE NWQKGCGGSG GVGSKGVYGV IRLLRASTTK TLFEGRITGL
160 170 180 190 200
KPGKHSLVVH EFGNLMNGCD DLGEPFISNV ENNNNNNNNN NNNNNNNNNN
210 220 230 240 250
NNNNNNNNKN INKCKEILNK IIGTSDVKQD GKAEFRVLSD KYDFWDLIGR
260 270 280 290 300
SIVLHSQDSK YSPIEDLNNN NNNKNIVNSE SDKILGERVA CGIISRAASI
310
GQNHKKVCPC DGTTAI
Length:316
Mass (Da):34,468
Last modified:May 24, 2005 - v1
Checksum:iC167C77135B10589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000174 Genomic DNA. Translation: EAL61946.1.
RefSeqiXP_635464.1. XM_630372.1.

Genome annotation databases

EnsemblProtistsiEAL61946; EAL61946; DDB_G0291031.
GeneIDi8627964.
KEGGiddi:DDB_G0291031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000174 Genomic DNA. Translation: EAL61946.1.
RefSeqiXP_635464.1. XM_630372.1.

3D structure databases

ProteinModelPortaliQ54F73.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ54F73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL61946; EAL61946; DDB_G0291031.
GeneIDi8627964.
KEGGiddi:DDB_G0291031.

Organism-specific databases

dictyBaseiDDB_G0291031. ccs.

Phylogenomic databases

InParanoidiQ54F73.
KOiK04569.
OMAiADTHKES.
PhylomeDBiQ54F73.

Miscellaneous databases

PROiQ54F73.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.60.40.200. 2 hits.
InterProiIPR006121. HMA_dom.
IPR024134. SOD_Cu/Zn_/chaperone.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 3 hits.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 2 hits.
SSF55008. SSF55008. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCS_DICDI
AccessioniPrimary (citable) accession number: Q54F73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.