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Q54F73

- CCS_DICDI

UniProt

Q54F73 - CCS_DICDI

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Protein
Probable copper chaperone for superoxide dismutase
Gene
ccs, ccsA, DDB_G0291031
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Delivers copper to copper zinc superoxide dismutases By similarity.

Cofactori

Binds 2 copper ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Copper 1 Reviewed prediction
Metal bindingi21 – 211Copper 1 Reviewed prediction
Metal bindingi308 – 3081Copper 2 By similarity
Metal bindingi310 – 3101Copper 2 By similarity

GO - Molecular functioni

  1. copper ion binding Source: RefGenome
  2. superoxide dismutase activity Source: RefGenome
  3. superoxide dismutase copper chaperone activity Source: dictyBase
  4. zinc ion binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. intracellular copper ion transport Source: dictyBase
  2. positive regulation of catalytic activity Source: GOC
  3. removal of superoxide radicals Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable copper chaperone for superoxide dismutase
Alternative name(s):
Superoxide dismutase copper chaperone
Gene namesi
Name:ccs
Synonyms:ccsA
ORF Names:DDB_G0291031
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291031. ccs.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. cytosol Source: dictyBase
  3. mitochondrial inner membrane Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Probable copper chaperone for superoxide dismutase
PRO_0000329400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi169 ↔ 291 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer, and heterodimer with SOD1 By similarity.

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0189222.

Structurei

3D structure databases

ProteinModelPortaliQ54F73.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7265HMA
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 298200Superoxide dismutase-like
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 847Poly-Thr
Compositional biasi182 – 21029Poly-Asn
Add
BLAST
Compositional biasi268 – 2758Poly-Asn

Sequence similaritiesi

In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
Contains 1 HMA domain.

Phylogenomic databases

eggNOGiNOG327209.
OMAiYGTEDKS.
PhylomeDBiQ54F73.

Family and domain databases

Gene3Di2.60.40.200. 2 hits.
InterProiIPR006121. HeavyMe-assoc_HMA.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 2 hits.
SSF55008. SSF55008. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54F73-1 [UniParc]FASTAAdd to Basket

« Hide

MDDKNLEIKV ELNVDISCQS CVDSISKELR EKLENTKLVE HDIPEQRIVL    50
QGTDLTQDIL ETIKNTGRNA TICGLSSTTT TTSTSPSSST CHKKQETVSG 100
SAVCSLGLIE NWQKGCGGSG GVGSKGVYGV IRLLRASTTK TLFEGRITGL 150
KPGKHSLVVH EFGNLMNGCD DLGEPFISNV ENNNNNNNNN NNNNNNNNNN 200
NNNNNNNNKN INKCKEILNK IIGTSDVKQD GKAEFRVLSD KYDFWDLIGR 250
SIVLHSQDSK YSPIEDLNNN NNNKNIVNSE SDKILGERVA CGIISRAASI 300
GQNHKKVCPC DGTTAI 316
Length:316
Mass (Da):34,468
Last modified:May 24, 2005 - v1
Checksum:iC167C77135B10589
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000174 Genomic DNA. Translation: EAL61946.1.
RefSeqiXP_635464.1. XM_630372.1.

Genome annotation databases

EnsemblProtistsiDDB0238038; DDB0238038; DDB_G0291031.
GeneIDi8627964.
KEGGiddi:DDB_G0291031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000174 Genomic DNA. Translation: EAL61946.1 .
RefSeqi XP_635464.1. XM_630372.1.

3D structure databases

ProteinModelPortali Q54F73.
ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0189222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0238038 ; DDB0238038 ; DDB_G0291031 .
GeneIDi 8627964.
KEGGi ddi:DDB_G0291031.

Organism-specific databases

dictyBasei DDB_G0291031. ccs.

Phylogenomic databases

eggNOGi NOG327209.
OMAi YGTEDKS.
PhylomeDBi Q54F73.

Miscellaneous databases

PROi Q54F73.

Family and domain databases

Gene3Di 2.60.40.200. 2 hits.
InterProi IPR006121. HeavyMe-assoc_HMA.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
SUPFAMi SSF49329. SSF49329. 2 hits.
SSF55008. SSF55008. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCCS_DICDI
AccessioniPrimary (citable) accession number: Q54F73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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