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Q54F73

- CCS_DICDI

UniProt

Q54F73 - CCS_DICDI

Protein

Probable copper chaperone for superoxide dismutase

Gene

ccs

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Delivers copper to copper zinc superoxide dismutases.By similarity

    Cofactori

    Binds 2 copper ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi18 – 181Copper 1Sequence Analysis
    Metal bindingi21 – 211Copper 1Sequence Analysis
    Metal bindingi308 – 3081Copper 2By similarity
    Metal bindingi310 – 3101Copper 2By similarity

    GO - Molecular functioni

    1. copper ion binding Source: RefGenome
    2. superoxide dismutase activity Source: RefGenome
    3. superoxide dismutase copper chaperone activity Source: dictyBase
    4. zinc ion binding Source: RefGenome

    GO - Biological processi

    1. intracellular copper ion transport Source: dictyBase
    2. positive regulation of catalytic activity Source: GOC
    3. removal of superoxide radicals Source: RefGenome

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable copper chaperone for superoxide dismutase
    Alternative name(s):
    Superoxide dismutase copper chaperone
    Gene namesi
    Name:ccs
    Synonyms:ccsA
    ORF Names:DDB_G0291031
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0291031. ccs.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: dictyBase
    3. mitochondrial inner membrane Source: dictyBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Probable copper chaperone for superoxide dismutasePRO_0000329400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi169 ↔ 291By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with SOD1.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0189222.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54F73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7265HMAAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni99 – 298200Superoxide dismutase-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi78 – 847Poly-Thr
    Compositional biasi182 – 21029Poly-AsnAdd
    BLAST
    Compositional biasi268 – 2758Poly-Asn

    Sequence similaritiesi

    In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.Curated
    Contains 1 HMA domain.Curated

    Phylogenomic databases

    eggNOGiNOG327209.
    OMAiYGTEDKS.
    PhylomeDBiQ54F73.

    Family and domain databases

    Gene3Di2.60.40.200. 2 hits.
    InterProiIPR006121. HeavyMe-assoc_HMA.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    SUPFAMiSSF49329. SSF49329. 2 hits.
    SSF55008. SSF55008. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54F73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDKNLEIKV ELNVDISCQS CVDSISKELR EKLENTKLVE HDIPEQRIVL    50
    QGTDLTQDIL ETIKNTGRNA TICGLSSTTT TTSTSPSSST CHKKQETVSG 100
    SAVCSLGLIE NWQKGCGGSG GVGSKGVYGV IRLLRASTTK TLFEGRITGL 150
    KPGKHSLVVH EFGNLMNGCD DLGEPFISNV ENNNNNNNNN NNNNNNNNNN 200
    NNNNNNNNKN INKCKEILNK IIGTSDVKQD GKAEFRVLSD KYDFWDLIGR 250
    SIVLHSQDSK YSPIEDLNNN NNNKNIVNSE SDKILGERVA CGIISRAASI 300
    GQNHKKVCPC DGTTAI 316
    Length:316
    Mass (Da):34,468
    Last modified:May 24, 2005 - v1
    Checksum:iC167C77135B10589
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000174 Genomic DNA. Translation: EAL61946.1.
    RefSeqiXP_635464.1. XM_630372.1.

    Genome annotation databases

    EnsemblProtistsiDDB0238038; DDB0238038; DDB_G0291031.
    GeneIDi8627964.
    KEGGiddi:DDB_G0291031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000174 Genomic DNA. Translation: EAL61946.1 .
    RefSeqi XP_635464.1. XM_630372.1.

    3D structure databases

    ProteinModelPortali Q54F73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0189222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0238038 ; DDB0238038 ; DDB_G0291031 .
    GeneIDi 8627964.
    KEGGi ddi:DDB_G0291031.

    Organism-specific databases

    dictyBasei DDB_G0291031. ccs.

    Phylogenomic databases

    eggNOGi NOG327209.
    OMAi YGTEDKS.
    PhylomeDBi Q54F73.

    Miscellaneous databases

    PROi Q54F73.

    Family and domain databases

    Gene3Di 2.60.40.200. 2 hits.
    InterProi IPR006121. HeavyMe-assoc_HMA.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49329. SSF49329. 2 hits.
    SSF55008. SSF55008. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiCCS_DICDI
    AccessioniPrimary (citable) accession number: Q54F73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3