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Q54F10 (NDUV2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Gene names
Name:ndufv2
ORF Names:DDB_G0291173
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 2Fe-2S cluster Potential.

Subunit structure

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion inner membrane By similarity.

Sequence similarities

Belongs to the complex I 24 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4040Mitochondrion Potential
Chain41 – 247207NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
PRO_0000328010

Sites

Metal binding1351Iron-sulfur (2Fe-2S) Potential
Metal binding1401Iron-sulfur (2Fe-2S) Potential
Metal binding1761Iron-sulfur (2Fe-2S) Potential
Metal binding1801Iron-sulfur (2Fe-2S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q54F10 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: DE27EC529EAC9760

FASTA24727,742
        10         20         30         40         50         60 
MFRSLLKRTT FLNQLNKSNG FNRNYFKQST LTRSDALSRH VETEDNNEHT PFDFTQENLV 

        70         80         90        100        110        120 
KVEKILAKYP KQYRQSALIP LLDLAQRQNG GWISLRAMDK VAHICGIAPM TAYEVASFYT 

       130        140        150        160        170        180 
MFNRTKIGEN FVQVCTTTPC MLRGSGEIIK TCKSHLGIQV GETTPDNKFT LVEVECLGAC 

       190        200        210        220        230        240 
VNAPMMCIND DFYEDLTSAS TINLLDQIKN NKPTKIGPQT HRKAAEGPQG KTTLLEPPVG 


PTCRDDL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000175 Genomic DNA. Translation: EAL61870.1.
RefSeqXP_635380.1. XM_630288.1.

3D structure databases

ProteinModelPortalQ54F10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0233206.

Proteomic databases

PRIDEQ54F10.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0233206; DDB0233206; DDB_G0291173.
GeneID8628028.
KEGGddi:DDB_G0291173.

Organism-specific databases

dictyBaseDDB_G0291173. ndufv2.

Phylogenomic databases

eggNOGCOG1905.
OMALGEMECM.
PhylomeDBQ54F10.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR10371. PTHR10371. 1 hit.
PIRSFPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR01958. nuoE_fam. 1 hit.
PROSITEPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54F10.

Entry information

Entry nameNDUV2_DICDI
AccessionPrimary (citable) accession number: Q54F10
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase