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Q54F10

- NDUV2_DICDI

UniProt

Q54F10 - NDUV2_DICDI

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Protein
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Gene
ndufv2, DDB_G0291173
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 2Fe-2S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi135 – 1351Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi140 – 1401Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi176 – 1761Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi180 – 1801Iron-sulfur (2Fe-2S) Reviewed prediction

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. NADH dehydrogenase (ubiquinone) activity Source: RefGenome
  3. electron carrier activity Source: dictyBase
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Gene namesi
Name:ndufv2
ORF Names:DDB_G0291173
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291173. ndufv2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex I Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040Mitochondrion Reviewed prediction
Add
BLAST
Chaini41 – 247207NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
PRO_0000328010Add
BLAST

Proteomic databases

PRIDEiQ54F10.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0233206.

Structurei

3D structure databases

ProteinModelPortaliQ54F10.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1905.
KOiK03943.
OMAiLGEMECM.
PhylomeDBiQ54F10.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10371. PTHR10371. 1 hit.
PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
PROSITEiPS01099. COMPLEX1_24K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54F10-1 [UniParc]FASTAAdd to Basket

« Hide

MFRSLLKRTT FLNQLNKSNG FNRNYFKQST LTRSDALSRH VETEDNNEHT    50
PFDFTQENLV KVEKILAKYP KQYRQSALIP LLDLAQRQNG GWISLRAMDK 100
VAHICGIAPM TAYEVASFYT MFNRTKIGEN FVQVCTTTPC MLRGSGEIIK 150
TCKSHLGIQV GETTPDNKFT LVEVECLGAC VNAPMMCIND DFYEDLTSAS 200
TINLLDQIKN NKPTKIGPQT HRKAAEGPQG KTTLLEPPVG PTCRDDL 247
Length:247
Mass (Da):27,742
Last modified:May 24, 2005 - v1
Checksum:iDE27EC529EAC9760
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000175 Genomic DNA. Translation: EAL61870.1.
RefSeqiXP_635380.1. XM_630288.1.

Genome annotation databases

EnsemblProtistsiDDB0233206; DDB0233206; DDB_G0291173.
GeneIDi8628028.
KEGGiddi:DDB_G0291173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000175 Genomic DNA. Translation: EAL61870.1 .
RefSeqi XP_635380.1. XM_630288.1.

3D structure databases

ProteinModelPortali Q54F10.
ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0233206.

Proteomic databases

PRIDEi Q54F10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233206 ; DDB0233206 ; DDB_G0291173 .
GeneIDi 8628028.
KEGGi ddi:DDB_G0291173.

Organism-specific databases

dictyBasei DDB_G0291173. ndufv2.

Phylogenomic databases

eggNOGi COG1905.
KOi K03943.
OMAi LGEMECM.
PhylomeDBi Q54F10.

Miscellaneous databases

PROi Q54F10.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002023. NuoE-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR10371. PTHR10371. 1 hit.
PIRSFi PIRSF000216. NADH_DH_24kDa. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
PROSITEi PS01099. COMPLEX1_24K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiNDUV2_DICDI
AccessioniPrimary (citable) accession number: Q54F10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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