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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Gene

ndufv2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[2Fe-2S] clusterCuratedNote: Binds 1 [2Fe-2S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi135Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi140Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi176Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi180Iron-sulfur (2Fe-2S)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-DDI-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Gene namesi
Name:ndufv2
ORF Names:DDB_G0291173
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291173 ndufv2

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40MitochondrionSequence analysisAdd BLAST40
ChainiPRO_000032801041 – 247NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialAdd BLAST207

Proteomic databases

PaxDbiQ54F10
PRIDEiQ54F10

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0233206

Structurei

3D structure databases

ProteinModelPortaliQ54F10
SMRiQ54F10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 24 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3196 Eukaryota
COG1905 LUCA
InParanoidiQ54F10
KOiK03943
OMAiNLTSEPW
PhylomeDBiQ54F10

Family and domain databases

CDDicd03064 TRX_Fd_NuoE, 1 hit
InterProiView protein in InterPro
IPR002023 NuoE-like
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR10371 PTHR10371, 1 hit
PIRSFiPIRSF000216 NADH_DH_24kDa, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01958 nuoE_fam, 1 hit
PROSITEiView protein in PROSITE
PS01099 COMPLEX1_24K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54F10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRSLLKRTT FLNQLNKSNG FNRNYFKQST LTRSDALSRH VETEDNNEHT
60 70 80 90 100
PFDFTQENLV KVEKILAKYP KQYRQSALIP LLDLAQRQNG GWISLRAMDK
110 120 130 140 150
VAHICGIAPM TAYEVASFYT MFNRTKIGEN FVQVCTTTPC MLRGSGEIIK
160 170 180 190 200
TCKSHLGIQV GETTPDNKFT LVEVECLGAC VNAPMMCIND DFYEDLTSAS
210 220 230 240
TINLLDQIKN NKPTKIGPQT HRKAAEGPQG KTTLLEPPVG PTCRDDL
Length:247
Mass (Da):27,742
Last modified:May 24, 2005 - v1
Checksum:iDE27EC529EAC9760
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000175 Genomic DNA Translation: EAL61870.1
RefSeqiXP_635380.1, XM_630288.1

Genome annotation databases

EnsemblProtistsiEAL61870; EAL61870; DDB_G0291173
GeneIDi8628028
KEGGiddi:DDB_G0291173

Similar proteinsi

Entry informationi

Entry nameiNDUV2_DICDI
AccessioniPrimary (citable) accession number: Q54F10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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