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Q54F10

- NDUV2_DICDI

UniProt

Q54F10 - NDUV2_DICDI

Protein

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Gene

ndufv2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 2Fe-2S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi135 – 1351Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi140 – 1401Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi176 – 1761Iron-sulfur (2Fe-2S)Sequence Analysis
    Metal bindingi180 – 1801Iron-sulfur (2Fe-2S)Sequence Analysis

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: dictyBase
    3. metal ion binding Source: UniProtKB-KW
    4. NADH dehydrogenase (ubiquinone) activity Source: RefGenome

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: RefGenome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Gene namesi
    Name:ndufv2
    ORF Names:DDB_G0291173
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0291173. ndufv2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex I Source: RefGenome

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4040MitochondrionSequence AnalysisAdd
    BLAST
    Chaini41 – 247207NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialPRO_0000328010Add
    BLAST

    Proteomic databases

    PRIDEiQ54F10.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0233206.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54F10.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 24 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1905.
    KOiK03943.
    OMAiLGEMECM.
    PhylomeDBiQ54F10.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR10371. PTHR10371. 1 hit.
    PIRSFiPIRSF000216. NADH_DH_24kDa. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01958. nuoE_fam. 1 hit.
    PROSITEiPS01099. COMPLEX1_24K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54F10-1 [UniParc]FASTAAdd to Basket

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    MFRSLLKRTT FLNQLNKSNG FNRNYFKQST LTRSDALSRH VETEDNNEHT    50
    PFDFTQENLV KVEKILAKYP KQYRQSALIP LLDLAQRQNG GWISLRAMDK 100
    VAHICGIAPM TAYEVASFYT MFNRTKIGEN FVQVCTTTPC MLRGSGEIIK 150
    TCKSHLGIQV GETTPDNKFT LVEVECLGAC VNAPMMCIND DFYEDLTSAS 200
    TINLLDQIKN NKPTKIGPQT HRKAAEGPQG KTTLLEPPVG PTCRDDL 247
    Length:247
    Mass (Da):27,742
    Last modified:May 24, 2005 - v1
    Checksum:iDE27EC529EAC9760
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000175 Genomic DNA. Translation: EAL61870.1.
    RefSeqiXP_635380.1. XM_630288.1.

    Genome annotation databases

    EnsemblProtistsiDDB0233206; DDB0233206; DDB_G0291173.
    GeneIDi8628028.
    KEGGiddi:DDB_G0291173.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000175 Genomic DNA. Translation: EAL61870.1 .
    RefSeqi XP_635380.1. XM_630288.1.

    3D structure databases

    ProteinModelPortali Q54F10.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0233206.

    Proteomic databases

    PRIDEi Q54F10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233206 ; DDB0233206 ; DDB_G0291173 .
    GeneIDi 8628028.
    KEGGi ddi:DDB_G0291173.

    Organism-specific databases

    dictyBasei DDB_G0291173. ndufv2.

    Phylogenomic databases

    eggNOGi COG1905.
    KOi K03943.
    OMAi LGEMECM.
    PhylomeDBi Q54F10.

    Miscellaneous databases

    PROi Q54F10.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR002023. NuoE-like.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR10371. PTHR10371. 1 hit.
    PIRSFi PIRSF000216. NADH_DH_24kDa. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01958. nuoE_fam. 1 hit.
    PROSITEi PS01099. COMPLEX1_24K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiNDUV2_DICDI
    AccessioniPrimary (citable) accession number: Q54F10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3