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Protein

Serine palmitoyltransferase 2

Gene

sptB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.By similarity

Catalytic activityi

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactori

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid metabolism, Sphingolipid metabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00222

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase 2 (EC:2.3.1.50)
Alternative name(s):
Long chain base biosynthesis protein 2
Short name:
LCB 2
Serine-palmitoyl-CoA transferase 2
Short name:
SPT 2
Short name:
SPT2
Gene namesi
Name:sptB
ORF Names:DDB_G0291283
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291283 sptB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278711 – 490Serine palmitoyltransferase 2Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ54EX5

Interactioni

Subunit structurei

Forms a heterodimer with sptA.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0232041

Structurei

3D structure databases

ProteinModelPortaliQ54EX5
SMRiQ54EX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1357 Eukaryota
COG0156 LUCA
InParanoidiQ54EX5
KOiK00654
OMAiPFFRVHE
PhylomeDBiQ54EX5

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q54EX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKEDVENV DDVGYLPILF LYIAYAFIIF NGKLAEFIGK LKGERYLHTP
60 70 80 90 100
EGYAPLFVEF EYFYQRRMYG RIKDAWDRPI NSIAGAWIDV MPRASKHYSQ
110 120 130 140 150
RLELTGGKTI KCLNLGSYNY LGFAQNEGPV ADKVIDSIYK YGVYTGSTSA
160 170 180 190 200
EVGLSEPQRD LENLTARFVG KEDAIVFEMG FATNSGTLPA LIGKGGLIIS
210 220 230 240 250
DSLNHASLAT GCKNTGCKVK VFRHNDSKHL EEVIRESIIQ GQPRTHRPWT
260 270 280 290 300
MILIIIEGIY SMEGEVANLP EILAIKKKYK CYLYIDEAHS IGALGKTGRG
310 320 330 340 350
IVDYYGIDPK EIDILMGTYT KSFGAIGGYV ASDKSLIDHL RQSSFSQVYA
360 370 380 390 400
NSMSPVCAVQ ALEALRVIMG EDGTDTGAKK LKQLHDNSNY FREKIREMGF
410 420 430 440 450
VILGNKDSPV IPLMLFNPAK LSAFSRLCLE KHIAVVVVGY PATPLTEPRT
460 470 480 490
RFCISASHTI EDLDWALRQI DEIGDLITLK FHKGKYLKSK
Length:490
Mass (Da):54,785
Last modified:May 24, 2005 - v1
Checksum:i052F6E2457F163D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA Translation: EAL61625.1
RefSeqiXP_635115.1, XM_630023.1

Genome annotation databases

EnsemblProtistsiEAL61625; EAL61625; DDB_G0291283
GeneIDi8628062
KEGGiddi:DDB_G0291283

Similar proteinsi

Entry informationi

Entry nameiSPTC2_DICDI
AccessioniPrimary (citable) accession number: Q54EX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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