Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine hydroxymethyltransferase 2

Gene

shmt2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Interconversion of serine and glycine.By similarity

Catalytic activityi

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-196757. Metabolism of folate and pterines.
R-DDI-71262. Carnitine synthesis.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferase 2 (EC:2.1.2.1By similarity)
Short name:
SHMT 2
Alternative name(s):
Glycine hydroxymethyltransferase 2
Serine methylase 2
Gene namesi
Name:shmt2
ORF Names:DDB_G0291652
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291652. shmt2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Serine hydroxymethyltransferase 2PRO_0000327958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ54EW1.
PRIDEiQ54EW1.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230073.

Structurei

3D structure databases

ProteinModelPortaliQ54EW1.
SMRiQ54EW1. Positions 24-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SHMT family.Curated

Phylogenomic databases

eggNOGiKOG2467. Eukaryota.
COG0112. LUCA.
InParanoidiQ54EW1.
KOiK00600.
OMAiIVCATTH.
PhylomeDBiQ54EW1.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54EW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSLSKLTP SIRGVVSINR SFCTKKFLPT NRSVSESDPE IYDLMMKEKQ
60 70 80 90 100
RQFTGLELIA SENFTSRAVM ESIGSCFTNK YAEGLPGARY YGGNEVVDQL
110 120 130 140 150
ENLCIKRALE TFNLNPEEWG VNVQPYSGST ANFAAFTGLL KPHDRIMGLD
160 170 180 190 200
LPSGGHLTHG YQTDKKKISA TSIFFESMPY QVNETGYVDY NKMEANAALF
210 220 230 240 250
RPKLLIAGAS AYPREWDYER MRKIADKHGA YLLCDMAHIS GMVAGKQAIS
260 270 280 290 300
PFLFCDVVTT TTHKTLRGPR AGLIFFRKTK RRDAKGNIID DDLENRINFA
310 320 330 340 350
VFPSCQGGPH ENTIAGIAVA LKEASSPDFQ EYTKQVRRNS QTMGEELKKR
360 370 380 390 400
GYSLVTEGTD NHLVLWDLRP QGITGSKIEK ACDEAHITVN KNAVYGDTNA
410 420 430 440 450
IAPGGVRLGA PALTSRGLKE QDFVKVVDFL DRVVKISLDI QSKVGKKMPD
460 470 480
FQRAIADNQD LKQIRQEVKE FSTKFGMPGE L
Length:481
Mass (Da):53,584
Last modified:May 24, 2005 - v1
Checksum:iFF08CBD911B2F727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA. Translation: EAL61810.1.
RefSeqiXP_635129.1. XM_630037.1.

Genome annotation databases

EnsemblProtistsiDDB0230073; DDB0230073; DDB_G0291652.
GeneIDi8628075.
KEGGiddi:DDB_G0291652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA. Translation: EAL61810.1.
RefSeqiXP_635129.1. XM_630037.1.

3D structure databases

ProteinModelPortaliQ54EW1.
SMRiQ54EW1. Positions 24-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0230073.

Proteomic databases

PaxDbiQ54EW1.
PRIDEiQ54EW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0230073; DDB0230073; DDB_G0291652.
GeneIDi8628075.
KEGGiddi:DDB_G0291652.

Organism-specific databases

dictyBaseiDDB_G0291652. shmt2.

Phylogenomic databases

eggNOGiKOG2467. Eukaryota.
COG0112. LUCA.
InParanoidiQ54EW1.
KOiK00600.
OMAiIVCATTH.
PhylomeDBiQ54EW1.

Enzyme and pathway databases

UniPathwayiUPA00193.
ReactomeiR-DDI-196757. Metabolism of folate and pterines.
R-DDI-71262. Carnitine synthesis.

Miscellaneous databases

PROiQ54EW1.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiGLYC2_DICDI
AccessioniPrimary (citable) accession number: Q54EW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 17, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.