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Protein

Serine hydroxymethyltransferase 2

Gene

shmt2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Interconversion of serine and glycine.By similarity

Catalytic activityi

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processOne-carbon metabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-196757 Metabolism of folate and pterines
R-DDI-71262 Carnitine synthesis
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferase 2 (EC:2.1.2.1By similarity)
Short name:
SHMT 2
Alternative name(s):
Glycine hydroxymethyltransferase 2
Serine methylase 2
Gene namesi
Name:shmt2
ORF Names:DDB_G0291652
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291652 shmt2

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003279581 – 481Serine hydroxymethyltransferase 2Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ54EW1
PRIDEiQ54EW1

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230073

Structurei

3D structure databases

ProteinModelPortaliQ54EW1
SMRiQ54EW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SHMT family.Curated

Phylogenomic databases

eggNOGiKOG2467 Eukaryota
COG0112 LUCA
InParanoidiQ54EW1
KOiK00600
OMAiNPSNFSG
PhylomeDBiQ54EW1

Family and domain databases

CDDicd00378 SHMT, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00051 SHMT, 1 hit
InterProiView protein in InterPro
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR001085 Ser_HO-MeTrfase
IPR019798 Ser_HO-MeTrfase_PLP_BS
PIRSFiPIRSF000412 SHMT, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00096 SHMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q54EW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSLSKLTP SIRGVVSINR SFCTKKFLPT NRSVSESDPE IYDLMMKEKQ
60 70 80 90 100
RQFTGLELIA SENFTSRAVM ESIGSCFTNK YAEGLPGARY YGGNEVVDQL
110 120 130 140 150
ENLCIKRALE TFNLNPEEWG VNVQPYSGST ANFAAFTGLL KPHDRIMGLD
160 170 180 190 200
LPSGGHLTHG YQTDKKKISA TSIFFESMPY QVNETGYVDY NKMEANAALF
210 220 230 240 250
RPKLLIAGAS AYPREWDYER MRKIADKHGA YLLCDMAHIS GMVAGKQAIS
260 270 280 290 300
PFLFCDVVTT TTHKTLRGPR AGLIFFRKTK RRDAKGNIID DDLENRINFA
310 320 330 340 350
VFPSCQGGPH ENTIAGIAVA LKEASSPDFQ EYTKQVRRNS QTMGEELKKR
360 370 380 390 400
GYSLVTEGTD NHLVLWDLRP QGITGSKIEK ACDEAHITVN KNAVYGDTNA
410 420 430 440 450
IAPGGVRLGA PALTSRGLKE QDFVKVVDFL DRVVKISLDI QSKVGKKMPD
460 470 480
FQRAIADNQD LKQIRQEVKE FSTKFGMPGE L
Length:481
Mass (Da):53,584
Last modified:May 24, 2005 - v1
Checksum:iFF08CBD911B2F727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA Translation: EAL61810.1
RefSeqiXP_635129.1, XM_630037.1

Genome annotation databases

EnsemblProtistsiEAL61810; EAL61810; DDB_G0291652
GeneIDi8628075
KEGGiddi:DDB_G0291652

Similar proteinsi

Entry informationi

Entry nameiGLYC2_DICDI
AccessioniPrimary (citable) accession number: Q54EW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health