Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q54ET5 (SYLM_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase, mitochondrial

EC=6.1.1.4
Alternative name(s):
LeuRM
Leucyl-tRNA synthetase
Gene names
Name:mleuS
ORF Names:DDB_G0291346
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length940 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049_B

Subcellular location

Mitochondrion By similarity HAMAP-Rule MF_00049_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 940Leucine--tRNA ligase, mitochondrial HAMAP-Rule MF_00049_BPRO_0000328292

Regions

Motif54 – 6411"HIGH" region By similarity
Motif638 – 6425"KMSKS" region By similarity

Sites

Binding site6411ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54ET5 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 275CCEC592792E38

FASTA940108,734
        10         20         30         40         50         60 
MFNLYRSSLK NLKLPNINNN IKSNLVIRSY TTNINGNIKN DDDNNKFYSL SQFPYPSGAL 

        70         80         90        100        110        120 
HMGHVRVYTI SDCIARLKRM QGYDVIHPMG WDAFGLPAEN AAIDKQVSPS EWTNLNISSM 

       130        140        150        160        170        180 
RDQLKLLNFQ FDWDRELSTC NKEYYRWTQE IFLRLLKSGL AYRKSATVNW DPIDQTVLAN 

       190        200        210        220        230        240 
EQVDAQGRSW RSNAIVEKKE MKQWFYKITS MADRLTDDLD QLPGWSDEIK NMQKEWIGRS 

       250        260        270        280        290        300 
YGHLIEFQSC AQKPLSNITV FTTRAETIYG VSFLAISPHH SEINQIRANL INDEKRLELD 

       310        320        330        340        350        360 
QYLKEIQEIK NKMGTQEDVE NLKTFNTGLT FYQPITKKYI PLILSNFVHA DYGTGAVMGV 

       370        380        390        400        410        420 
PSHNRSDYQV AKQQNLKLLP VLGIEREQQQ QQQQQQQQQQ LEIEEECYDY SNTGKLINSG 

       430        440        450        460        470        480 
QDTGIEFKEF IKRLEDQQLI KRQTNYRIHD WLISRQRYWG TPIPIIVCEK CGDVPVPSDQ 

       490        500        510        520        530        540 
LPVELPIDIQ FTGKGNLLNQ LDHWKNVKCP CCGSQATRET DTMDTFVDSS WYFLRFLDSK 

       550        560        570        580        590        600 
NSQSIFSSEL VNRFMPIDVY VGGIEHAILH LLYSRFITKF LKDQQLIDHS EPFKVLLAQG 

       610        620        630        640        650        660 
LVKSPTYRDS ITNKPIHPSN VEFKTIKSNE SGKSQQQTIN KLTGNQVSVT IEKMSKSKLN 

       670        680        690        700        710        720 
GIDPKEIIDK YGSDTLKTYI LFKAPPEKSL DWDTQGIEGC KKWLTRINVS IQSFLNQFDV 

       730        740        750        760        770        780 
IEGKEQHQHQ QQQHQQPLPS SEFNEQQSKE VKDILFETHL TMNKVTESID KHSFNTGIAA 

       790        800        810        820        830        840 
LMELSNTLQK SSPQIKLTKE YYQSLRALTL MLFPFSPIFS QIHWKSLIDD LPQSCKSFYS 

       850        860        870        880        890        900 
ENYSSFEQQS YGNSNDNDVF NQRWPKPTPS ALVRDFNSLV IQFDGKTKGV ESIPTSITDF 

       910        920        930        940 
SNFVQSNSKY LNRFKDKTID QIFIGTTKTG NSINFTFKKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000177 Genomic DNA. Translation: EAL61657.1.

3D structure databases

ProteinModelPortalQ54ET5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231251.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231251; DDB0231251; DDB_G0291346.
KEGGddi:DDB_G0291346.

Organism-specific databases

dictyBaseDDB_G0291346. mleuS.

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAGIEHACM.
PhylomeDBQ54ET5.
ProtClustDBCLSZ2497094.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54ET5.

Entry information

Entry nameSYLM_DICDI
AccessionPrimary (citable) accession number: Q54ET5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries