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Protein

Putative synaptobrevin homolog YKT6

Gene

ykt6

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport and in early/recycling endosome to TGN transport as part of a SNARE complex. Has a S-palmitoyl transferase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-DDI-6807878. COPI-mediated anterograde transport.
R-DDI-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative synaptobrevin homolog YKT6 (EC:2.3.1.-)
Alternative name(s):
Putative prenylated SNARE protein ykt6
Gene namesi
Name:ykt6
ORF Names:DDB_G0291656
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291656. ykt6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Putative synaptobrevin homolog YKT6PRO_0000328314Add
BLAST
Propeptidei200 – 2023Removed in mature formBy similarityPRO_0000396668

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi198 – 1981S-palmitoyl cysteineBy similarity
Modified residuei199 – 1991Cysteine methyl esterBy similarity
Lipidationi199 – 1991S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ54ES8.
PRIDEiQ54ES8.

Interactioni

Subunit structurei

May be found in 2 different SNARE complexes.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0238214.

Structurei

3D structure databases

ProteinModelPortaliQ54ES8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 129123LonginPROSITE-ProRule annotationAdd
BLAST
Domaini142 – 20261v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0861. Eukaryota.
COG5143. LUCA.
InParanoidiQ54ES8.
KOiK08516.
OMAiRICLEEF.
PhylomeDBiQ54ES8.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54ES8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVYSIGLFK VVPGNKPVLL NIVYELSSFG FFQRGSVKEV SLFVSRETVG
60 70 80 90 100
RTNVGERVSM EHTQTQKVCH TTVDSKGLGC SVLTDSEYPG RVAHTLIRIC
110 120 130 140 150
LEEFYKVHPE SEWRGLQSDV ELQTPALDQL LLKYQNPETA DPMMNLQKNL
160 170 180 190 200
DETITIVKKT VEQLGQRGEK LDDLAAKSDD LSFQSKAFMN NAERMNKCCG

YV
Length:202
Mass (Da):22,771
Last modified:May 24, 2005 - v1
Checksum:iD31A9B37848DE5C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA. Translation: EAL61812.1.
RefSeqiXP_635162.1. XM_630070.1.

Genome annotation databases

EnsemblProtistsiDDB0238214; DDB0238214; DDB_G0291656.
GeneIDi8628108.
KEGGiddi:DDB_G0291656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA. Translation: EAL61812.1.
RefSeqiXP_635162.1. XM_630070.1.

3D structure databases

ProteinModelPortaliQ54ES8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238214.

Proteomic databases

PaxDbiQ54ES8.
PRIDEiQ54ES8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0238214; DDB0238214; DDB_G0291656.
GeneIDi8628108.
KEGGiddi:DDB_G0291656.

Organism-specific databases

dictyBaseiDDB_G0291656. ykt6.

Phylogenomic databases

eggNOGiKOG0861. Eukaryota.
COG5143. LUCA.
InParanoidiQ54ES8.
KOiK08516.
OMAiRICLEEF.
PhylomeDBiQ54ES8.

Enzyme and pathway databases

ReactomeiR-DDI-6807878. COPI-mediated anterograde transport.
R-DDI-6811438. Intra-Golgi traffic.

Miscellaneous databases

PROiQ54ES8.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
    Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
    Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: AX2.

Entry informationi

Entry nameiYKT6_DICDI
AccessioniPrimary (citable) accession number: Q54ES8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.