Q54EP3 (POP5_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ribonuclease P/MRP protein subunit POP5
EC=3.1.26.5

Gene names

Name:	pop5
ORF Names:	DDB_G0291662

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	rRNA processing Inferred by curator. Source: dictyBase tRNA processing Inferred by curator. Source: dictyBase
Cellular_component	nucleolar ribonuclease P complex Inferred from sequence or structural similarity. Source: dictyBase ribonuclease MRP complex Inferred from sequence or structural similarity. Source: dictyBase
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Probable ribonuclease P/MRP protein subunit POP5		PRO_0000327380

Sequences

	Sequence		Length	Mass (Da)
	Q54EP3 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 0225413D5ACE16C5	FASTA	171	19,916
	10 20 30 40 50 60 MVRLKNRYLM TEVIWHDNEK STQLSDSWLF QFISNEVKEK LGELTYEAFK KTLKIIYVNP 70 80 90 100 110 120 DTNIFIIRVS FEYYKSLWTA LTLITSYYGV PIYFRMVHVG GSIRLCQKAA IKIFGKQISV 130 140 150 160 170 YDKNKILRNE KGETIDNNNN KNEEPSIKMD SDDDENGGGD DGEDNDSEMK D

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000177 Genomic DNA. Translation: EAL61815.1.
RefSeq	XP_635197.1. XM_630105.1.
3D structure databases
ProteinModelPortal	Q54EP3.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDBDRAFT_0219669.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0237627; DDB0237627; DDB_G0291662.
GeneID	8628142.
KEGG	ddi:DDB_G0291662.
Organism-specific databases
dictyBase	DDB_G0291662. pop5.
Phylogenomic databases
eggNOG	COG1369.
KO	K03537.
OMA	FQFISNE.
ProtClustDB	CLSZ2429561.
Family and domain databases
InterPro	IPR016819. RNase_P/MRP_POP5. IPR002759. RNase_P/MRP_subunit. [Graphical view]
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
PIRSF	PIRSF023803. Ribonuclease_P_prd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

POP5_DICDI

Accession

Primary (citable) accession number: Q54EP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)