Reviewed, UniProtKB/Swiss-Prot Q54EP3 (POP5_DICDI)

Names and origin

Protein names

Recommended name:
    Probable ribonuclease P/MRP protein subunit POP5
    EC=3.1.26.5

Gene names

Name:	pop5
ORF Names:	DDB_G0291662

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Probable ribonuclease P/MRP protein subunit POP5		PRO_0000327380

Sequences

	Sequence		Length	Mass (Da)
	Q54EP3-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 0225413D5ACE16C5	FASTA	171	19,916
	10 20 30 40 50 60 MVRLKNRYLM TEVIWHDNEK STQLSDSWLF QFISNEVKEK LGELTYEAFK KTLKIIYVNP 70 80 90 100 110 120 DTNIFIIRVS FEYYKSLWTA LTLITSYYGV PIYFRMVHVG GSIRLCQKAA IKIFGKQISV 130 140 150 160 170 YDKNKILRNE KGETIDNNNN KNEEPSIKMD SDDDENGGGD DGEDNDSEMK D

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000177 Genomic DNA. Translation: EAL61815.1.
RefSeq	XP_635197.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3386867.
GenomeReviews	Gene locus pop5 in contig CM000155_GR.
KEGG	ddi:DDB_0237627.
Organism-specific databases
dictyBase	DDB_G0291662. pop5.
Phylogenomic databases
OMA	LTVKYFS.
Enzyme and pathway databases
BRENDA	3.1.26.5. 424.
Family and domain databases
InterPro	IPR016819. RNase_P/MRP_POP5. IPR002759. RNase_P_related. [Graphical view]
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
PIRSF	PIRSF023803. Ribonuclease_P_prd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

POP5_DICDI

Accession

Primary (citable) accession number: Q54EP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)