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Q54EN4

- PDI2_DICDI

UniProt

Q54EN4 - PDI2_DICDI

Protein

Protein disulfide-isomerase 2

Gene

pdi2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei70 – 701NucleophileBy similarity
    Active sitei73 – 731NucleophileBy similarity
    Active sitei406 – 4061NucleophileBy similarity
    Active sitei409 – 4091NucleophileBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: dictyBase

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. protein folding Source: dictyBase
    3. response to bacterium Source: dictyBase
    4. response to endoplasmic reticulum stress Source: RefGenome
    5. sexual reproduction Source: dictyBase

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase 2 (EC:5.3.4.1)
    Short name:
    PDI2
    Gene namesi
    Name:pdi2
    ORF Names:DDB_G0291434
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0291434. pdi2.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. phagocytic vesicle Source: dictyBase

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 513493Protein disulfide-isomerase 2PRO_0000327613Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi70 ↔ 73Redox-activePROSITE-ProRule annotation
    Disulfide bondi406 ↔ 409Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ54EN4.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231409.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54EN4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 147127Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini355 – 486132Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi510 – 5134Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    KOiK09580.
    OMAiVNENAIT.
    PhylomeDBiQ54EN4.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 3 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 2 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54EN4-1 [UniParc]FASTAAdd to Basket

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    MNKFLALLFV LALFANIAFS CEGHPEHDHG DGDHEHDHDE SFVKILDSDN    50
    FHNSVSEHDV TLVMFYAPWC GHCKTLKPLY EEAAKQLSAN KKIAIAKVDC 100
    TQHEQLCKQN KVQGYPTLVV FKNGKAEPYE GDRTTKSIVQ TLEEELKPTI 150
    STLESNEDIE EFKKQHPISV VGFFDNDHDD RFKLFSELAG NNKKSAKFAV 200
    VIDKDFSKEH VESTPNVVLF RSFDEPTVAH KGEFDSESLI KFIKGNSVPL 250
    LGEINRNTYK KYESIAVPLA YLFIDSTQDN TQVLEDVKKI ATSQKGNAVF 300
    CWVDMKKFPQ QATHMGLSGK VVPAISVDSV ANKARYNFDE KETFSFDTVS 350
    KWIQDVIGGK VSPFVKSQPE PESNDAPVKV AVGTTFKKLV LDSPKDVLVE 400
    FYAPWCGHCK NLAPIYDKLG EYLKDVESVS IVKIDADSND VPSDIEIRGY 450
    PTIMLFKADD KENPISYEGQ RNDHMNFVEF IQDNAAIEFK LPSSQTDDNV 500
    ESKKDSSAKH DEL 513
    Length:513
    Mass (Da):57,753
    Last modified:May 24, 2005 - v1
    Checksum:i8AAB6B6926069852
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000177 Genomic DNA. Translation: EAL61701.1.
    RefSeqiXP_635206.1. XM_630114.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231409; DDB0231409; DDB_G0291434.
    GeneIDi8628151.
    KEGGiddi:DDB_G0291434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000177 Genomic DNA. Translation: EAL61701.1 .
    RefSeqi XP_635206.1. XM_630114.1.

    3D structure databases

    ProteinModelPortali Q54EN4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231409.

    Proteomic databases

    PRIDEi Q54EN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231409 ; DDB0231409 ; DDB_G0291434 .
    GeneIDi 8628151.
    KEGGi ddi:DDB_G0291434.

    Organism-specific databases

    dictyBasei DDB_G0291434. pdi2.

    Phylogenomic databases

    eggNOGi COG0526.
    KOi K09580.
    OMAi VNENAIT.
    PhylomeDBi Q54EN4.

    Miscellaneous databases

    PROi Q54EN4.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 3 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 2 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPDI2_DICDI
    AccessioniPrimary (citable) accession number: Q54EN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3