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Q54EN4 (PDI2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein disulfide-isomerase 2

Short name=PDI2
EC=5.3.4.1
Gene names
Name:pdi2
ORF Names:DDB_G0291434
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer By similarity.

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 2 thioredoxin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 513493Protein disulfide-isomerase 2
PRO_0000327613

Regions

Domain21 – 147127Thioredoxin 1
Domain355 – 486132Thioredoxin 2
Motif510 – 5134Prevents secretion from ER Potential

Sites

Active site701Nucleophile By similarity
Active site731Nucleophile By similarity
Active site4061Nucleophile By similarity
Active site4091Nucleophile By similarity

Amino acid modifications

Disulfide bond70 ↔ 73Redox-active By similarity
Disulfide bond406 ↔ 409Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54EN4 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 8AAB6B6926069852

FASTA51357,753
        10         20         30         40         50         60 
MNKFLALLFV LALFANIAFS CEGHPEHDHG DGDHEHDHDE SFVKILDSDN FHNSVSEHDV 

        70         80         90        100        110        120 
TLVMFYAPWC GHCKTLKPLY EEAAKQLSAN KKIAIAKVDC TQHEQLCKQN KVQGYPTLVV 

       130        140        150        160        170        180 
FKNGKAEPYE GDRTTKSIVQ TLEEELKPTI STLESNEDIE EFKKQHPISV VGFFDNDHDD 

       190        200        210        220        230        240 
RFKLFSELAG NNKKSAKFAV VIDKDFSKEH VESTPNVVLF RSFDEPTVAH KGEFDSESLI 

       250        260        270        280        290        300 
KFIKGNSVPL LGEINRNTYK KYESIAVPLA YLFIDSTQDN TQVLEDVKKI ATSQKGNAVF 

       310        320        330        340        350        360 
CWVDMKKFPQ QATHMGLSGK VVPAISVDSV ANKARYNFDE KETFSFDTVS KWIQDVIGGK 

       370        380        390        400        410        420 
VSPFVKSQPE PESNDAPVKV AVGTTFKKLV LDSPKDVLVE FYAPWCGHCK NLAPIYDKLG 

       430        440        450        460        470        480 
EYLKDVESVS IVKIDADSND VPSDIEIRGY PTIMLFKADD KENPISYEGQ RNDHMNFVEF 

       490        500        510 
IQDNAAIEFK LPSSQTDDNV ESKKDSSAKH DEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000177 Genomic DNA. Translation: EAL61701.1.
RefSeqXP_635206.1. XM_630114.1.

3D structure databases

ProteinModelPortalQ54EN4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231409.

Proteomic databases

PRIDEQ54EN4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231409; DDB0231409; DDB_G0291434.
GeneID8628151.
KEGGddi:DDB_G0291434.

Organism-specific databases

dictyBaseDDB_G0291434. pdi2.

Phylogenomic databases

eggNOGCOG0526.
OMAVNENAIT.
PhylomeDBQ54EN4.

Family and domain databases

Gene3D3.40.30.10. 3 hits.
InterProIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMSSF52833. SSF52833. 3 hits.
TIGRFAMsTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ54EN4.

Entry information

Entry namePDI2_DICDI
AccessionPrimary (citable) accession number: Q54EN4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase