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Q54EN4

- PDI2_DICDI

UniProt

Q54EN4 - PDI2_DICDI

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Protein
Protein disulfide-isomerase 2
Gene
pdi2, DDB_G0291434
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer By similarity.

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Nucleophile By similarity
Active sitei73 – 731Nucleophile By similarity
Active sitei406 – 4061Nucleophile By similarity
Active sitei409 – 4091Nucleophile By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: dictyBase
Complete GO annotation...

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: dictyBase
  3. response to bacterium Source: dictyBase
  4. response to endoplasmic reticulum stress Source: RefGenome
  5. sexual reproduction Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase 2 (EC:5.3.4.1)
Short name:
PDI2
Gene namesi
Name:pdi2
ORF Names:DDB_G0291434
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291434. pdi2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  3. phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 513493Protein disulfide-isomerase 2
PRO_0000327613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 73Redox-active By similarity
Disulfide bondi406 ↔ 409Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ54EN4.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231409.

Structurei

3D structure databases

ProteinModelPortaliQ54EN4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 147127Thioredoxin 1
Add
BLAST
Domaini355 – 486132Thioredoxin 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi510 – 5134Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 2 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
KOiK09580.
OMAiVNENAIT.
PhylomeDBiQ54EN4.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54EN4-1 [UniParc]FASTAAdd to Basket

« Hide

MNKFLALLFV LALFANIAFS CEGHPEHDHG DGDHEHDHDE SFVKILDSDN    50
FHNSVSEHDV TLVMFYAPWC GHCKTLKPLY EEAAKQLSAN KKIAIAKVDC 100
TQHEQLCKQN KVQGYPTLVV FKNGKAEPYE GDRTTKSIVQ TLEEELKPTI 150
STLESNEDIE EFKKQHPISV VGFFDNDHDD RFKLFSELAG NNKKSAKFAV 200
VIDKDFSKEH VESTPNVVLF RSFDEPTVAH KGEFDSESLI KFIKGNSVPL 250
LGEINRNTYK KYESIAVPLA YLFIDSTQDN TQVLEDVKKI ATSQKGNAVF 300
CWVDMKKFPQ QATHMGLSGK VVPAISVDSV ANKARYNFDE KETFSFDTVS 350
KWIQDVIGGK VSPFVKSQPE PESNDAPVKV AVGTTFKKLV LDSPKDVLVE 400
FYAPWCGHCK NLAPIYDKLG EYLKDVESVS IVKIDADSND VPSDIEIRGY 450
PTIMLFKADD KENPISYEGQ RNDHMNFVEF IQDNAAIEFK LPSSQTDDNV 500
ESKKDSSAKH DEL 513
Length:513
Mass (Da):57,753
Last modified:May 24, 2005 - v1
Checksum:i8AAB6B6926069852
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000177 Genomic DNA. Translation: EAL61701.1.
RefSeqiXP_635206.1. XM_630114.1.

Genome annotation databases

EnsemblProtistsiDDB0231409; DDB0231409; DDB_G0291434.
GeneIDi8628151.
KEGGiddi:DDB_G0291434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000177 Genomic DNA. Translation: EAL61701.1 .
RefSeqi XP_635206.1. XM_630114.1.

3D structure databases

ProteinModelPortali Q54EN4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231409.

Proteomic databases

PRIDEi Q54EN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231409 ; DDB0231409 ; DDB_G0291434 .
GeneIDi 8628151.
KEGGi ddi:DDB_G0291434.

Organism-specific databases

dictyBasei DDB_G0291434. pdi2.

Phylogenomic databases

eggNOGi COG0526.
KOi K09580.
OMAi VNENAIT.
PhylomeDBi Q54EN4.

Miscellaneous databases

PROi Q54EN4.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 3 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPDI2_DICDI
AccessioniPrimary (citable) accession number: Q54EN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi