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Protein

Protein disulfide-isomerase 2

Gene

pdi2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei70NucleophileBy similarity1
Active sitei73NucleophileBy similarity1
Active sitei406NucleophileBy similarity1
Active sitei409NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-DDI-901042 Calnexin/calreticulin cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase 2 (EC:5.3.4.1)
Short name:
PDI2
Gene namesi
Name:pdi2
ORF Names:DDB_G0291434
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291434 pdi2

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000032761321 – 513Protein disulfide-isomerase 2Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 73Redox-activePROSITE-ProRule annotation
Disulfide bondi406 ↔ 409Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ54EN4
PRIDEiQ54EN4

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231409

Structurei

3D structure databases

ProteinModelPortaliQ54EN4
SMRiQ54EN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 147Thioredoxin 1PROSITE-ProRule annotationAdd BLAST127
Domaini355 – 486Thioredoxin 2PROSITE-ProRule annotationAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi510 – 513Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
InParanoidiQ54EN4
KOiK09580
OMAiQYGVRGY
PhylomeDBiQ54EN4

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 2 hits
SUPFAMiSSF52833 SSF52833, 3 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 2 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54EN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKFLALLFV LALFANIAFS CEGHPEHDHG DGDHEHDHDE SFVKILDSDN
60 70 80 90 100
FHNSVSEHDV TLVMFYAPWC GHCKTLKPLY EEAAKQLSAN KKIAIAKVDC
110 120 130 140 150
TQHEQLCKQN KVQGYPTLVV FKNGKAEPYE GDRTTKSIVQ TLEEELKPTI
160 170 180 190 200
STLESNEDIE EFKKQHPISV VGFFDNDHDD RFKLFSELAG NNKKSAKFAV
210 220 230 240 250
VIDKDFSKEH VESTPNVVLF RSFDEPTVAH KGEFDSESLI KFIKGNSVPL
260 270 280 290 300
LGEINRNTYK KYESIAVPLA YLFIDSTQDN TQVLEDVKKI ATSQKGNAVF
310 320 330 340 350
CWVDMKKFPQ QATHMGLSGK VVPAISVDSV ANKARYNFDE KETFSFDTVS
360 370 380 390 400
KWIQDVIGGK VSPFVKSQPE PESNDAPVKV AVGTTFKKLV LDSPKDVLVE
410 420 430 440 450
FYAPWCGHCK NLAPIYDKLG EYLKDVESVS IVKIDADSND VPSDIEIRGY
460 470 480 490 500
PTIMLFKADD KENPISYEGQ RNDHMNFVEF IQDNAAIEFK LPSSQTDDNV
510
ESKKDSSAKH DEL
Length:513
Mass (Da):57,753
Last modified:May 24, 2005 - v1
Checksum:i8AAB6B6926069852
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA Translation: EAL61701.1
RefSeqiXP_635206.1, XM_630114.1

Genome annotation databases

EnsemblProtistsiEAL61701; EAL61701; DDB_G0291434
GeneIDi8628151
KEGGiddi:DDB_G0291434

Entry informationi

Entry nameiPDI2_DICDI
AccessioniPrimary (citable) accession number: Q54EN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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