Q54EK2 (ABCC7_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter C family member 7

Alternative name(s):
ABC transporter ABCC.7

Gene names

Name:	abcC7
ORF Names:	DDB_G0291243

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.
Sequence caution	The sequence AAL85710.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from sequence or structural similarity Ref.2. Source: dictyBase organic anion transmembrane transporter activity Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1328	1328	ABC transporter C family member 7		PRO_0000363852
Regions
	Transmembrane	112 – 132	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	245 – 265	21	Helical; Potential
	Transmembrane	287 – 307	21	Helical; Potential
	Transmembrane	333 – 353	21	Helical; Potential
	Transmembrane	762 – 782	21	Helical; Potential
	Transmembrane	802 – 822	21	Helical; Potential
	Transmembrane	894 – 914	21	Helical; Potential
	Transmembrane	988 – 1008	21	Helical; Potential
	Transmembrane	1014 – 1034	21	Helical; Potential
	Domain	104 – 389	286	ABC transmembrane type-1 1
	Domain	457 – 678	222	ABC transporter 1
	Domain	765 – 1046	282	ABC transmembrane type-1 2
	Domain	1083 – 1316	234	ABC transporter 2
	Nucleotide binding	490 – 497	8	ATP Potential
	Nucleotide binding	1117 – 1124	8	ATP Potential
	Compositional bias	452 – 455	4	Poly-Asp
	Compositional bias	685 – 696	12	Poly-Asn
	Compositional bias	698 – 701	4	Poly-Glu
	Compositional bias	710 – 713	4	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q54EK2 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 0B641C07B1DCA367	FASTA	1,328	152,024
	10 20 30 40 50 60 MKNKKKIKNK ISYSLLEREL MGSRENEIAP EDCASFLSRI TYSWTQKMLI YGYFNTLQLK 70 80 90 100 110 120 DVPDLPESIK VENTTPILDE FKFKKNEKFG LVWFIYKRFV MVRHKTSIIV QIFSAIVSVL 130 140 150 160 170 180 SPLCLRAFIL YVQREPSEKS FLVGLFYAVL VLMGALFLSI SLQHTYWYTM KCGLEVKGAL 190 200 210 220 230 240 TSKIYSKTLK LSNYGKRLYS SGTILNLISS DCQNFADYFW IDYLILLVAP IQIIALLALL 250 260 270 280 290 300 CWTIGYSGLV GFLIMILSLP LSTFLSSKVS KYQLLSLKYS DKRCNLISEM INGIYLLKLY 310 320 330 340 350 360 NWELFFINRI EKQRKQQLIN LYKRMAFWAL DKMVVQISSA LVLVSSFTVY TLIANKSITY 370 380 390 400 410 420 EVAFTSISIF SNLREPCELL PQAIQRLLSL LPSSDRICKF LYETSEIIEN LSTITTTNGT 430 440 450 460 470 480 NQDILITNGT FDWNDNNKNI NVGVDSQENK NDDDDMIELV NNDSIETTTS YVLDDINFIA 490 500 510 520 530 540 PAGKLTIICG VVGSGKSSLI NGLIGEIYKV SGQVTIPNTV SFTNQQPFLV NSTLRENILF 550 560 570 580 590 600 GLPMDMDRYK KVLESCSLLT DLQSMPGKDL TEIGERGINL SGGQKQRINL ARALYSNSDC 610 620 630 640 650 660 YILDEPLSAV DPQVATHLFN HCIQGELMNN KTRILVTHQL QFIPSADHIV VLENGILTQG 670 680 690 700 710 720 TYQELKDKFD FESIMKTKKL NLELNNSNNN NNNNNNKEEE EDVENLEKEQ QQQVINVNDV 730 740 750 760 770 780 ISNEFESKND ELNSKLLVNE ERETGSVELN IYKMYIKYGS SFIFFFTMIM MYIISQLLFL 790 800 810 820 830 840 LFDYWLTIWS DEKKNKNGTK GDSFYILYYL LLVGLFSVFL GIRYFMILHF TNSSSKNLHD 850 860 870 880 890 900 KLLKSIGYAS CQFFDINSSG RINNRFTKDI AEVDLILMVL SDALYCGSTV LVAVLMMIVI 910 920 930 940 950 960 NPLIVFPFLL LALFYYLVQK LYRSSSLELK RLENISRSPI FSILSESFNG LITIRSFRQQ 970 980 990 1000 1010 1020 SRFIKRMQDS INVNLRLFYY NFSAHRWIGI KIEIISSAAV FLSAFFSLFN SNTGLSVLAV 1030 1040 1050 1060 1070 1080 TTSLSLTGYL NWCIRQYIEF SMKMSSVERI ENYINQPREG DTMNVDMELE SNLPINWPQK 1090 1100 1110 1120 1130 1140 GEIQFKNVEI KYRPNLKPSL KNISFDIKSN EKIGIVGKSG SGKSTTMLAL FRMIECSKGS 1150 1160 1170 1180 1190 1200 IHIDGIDISK ISLSKLRNSI GICPQEPFIF SGTIRKNIDP FGIYSDSEIW LALEKVKLKE 1210 1220 1230 1240 1250 1260 TISLLPMKID TIIHEQANLS FGQKQLLCLT RVLLKSPKLV FFDEHSSSID YFTAHQLNIS 1270 1280 1290 1300 1310 1320 VKENITNSTT LTIAHRIDTI IDSDRILVID SGELIEIFDK NNINNNINNQ NSKFKKFVQH TSDHFKNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-1328, NOMENCLATURE. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000177 Genomic DNA. Translation: EAL61605.1. AF474339 Genomic DNA. Translation: AAL85710.1. Different initiation.
RefSeq	XP_635238.1. XM_630146.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ProteinModelPortal	Q54EK2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0201630; DDB0201630; DDB_G0291243.
GeneID	8628184.
GenomeReviews	Gene locus abcC7 in contig CM000155_GR.
KEGG	ddi:DDB_G0291243.
Organism-specific databases
dictyBase	DDB_G0291243. abcC7.
Phylogenomic databases
eggNOG	KOG0054.
GeneTree	EPrGT00050000000398.
HOGENOM	HBG758042.
InParanoid	Q54EK2.
OMA	WRLELAN.
PhylomeDB	Q54EK2.
ProtClustDB	CLSZ2430599.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCC7_DICDI

Accession

Primary (citable) accession number: Q54EK2
Secondary accession number(s): Q8T6H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)