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Protein

Probable polyketide synthase 41

Gene

pks41

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable polyketide synthase.By similarity

Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177For beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei638For acyl/malonyl transferase activityPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiR-DDI-163765. ChREBP activates metabolic gene expression.
R-DDI-199220. Vitamin B5 (pantothenate) metabolism.
R-DDI-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable polyketide synthase 41 (EC:2.3.1.-)
Short name:
dipks41
Gene namesi
Name:pks41
ORF Names:DDB_G0291684
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291684. pks41.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003713981 – 2542Probable polyketide synthase 41Add BLAST2542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2496O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiQ54ED6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235301.

Structurei

3D structure databases

ProteinModelPortaliQ54ED6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2464 – 2531Acyl carrierPROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni158 – 211Beta-ketoacyl synthaseAdd BLAST54
Regioni628 – 661Acyl/malonyl transferaseAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi178 – 181Poly-Ser4

Domaini

Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity

Sequence similaritiesi

Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1202. Eukaryota.
COG3321. LUCA.
InParanoidiQ54ED6.
OMAiRIEANDT.
PhylomeDBiQ54ED6.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.150. 1 hit.
3.40.50.720. 2 hits.
3.90.180.10. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR013217. Methyltransf_12.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR009081. PP-bd_ACP.
IPR029063. SAM-dependent_MTases.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF16197. KAsynt_C_assoc. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 1 hit.
PF14765. PS-DH. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 2 hits.
SSF52151. SSF52151. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF53901. SSF53901. 1 hit.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54ED6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKNLVDEN CNKVAIIGIG FRFPNLKGDI TPNELWSKLL NRYDGIVKND
60 70 80 90 100
RWNESFFKSG DISTNYAGFI PFEELKSFDP LFFGINPSEG IHMCPQQRLL
110 120 130 140 150
LKCTWEALED SGIDPIEIRG SNTSVFIGCS GADYQNLNKN DNKVQQEIFS
160 170 180 190 200
SSTHSISNRV SYCFDLHGES MTIDTACSSS SNAIRRGYKS IIDGSSNISV
210 220 230 240 250
VGGINILLDP NISKSYSRLN ILSKDGKCKS FDAGADGYVR SDAAGIAILK
260 270 280 290 300
NLNDAIKDDN NIYCVIDGSA SNVDGNGFSD KSNFYSPSKS SQVECIRLAL
310 320 330 340 350
ESTNGQVNEN DIVYFEAHGT GTPTGDPIEL ESVSIALKTS ENRSSDNPLL
360 370 380 390 400
IGSFKPNIGH TESASGISSL IKCCLILKNQ CFVPNLNFNK PNPLIKFDQW
410 420 430 440 450
NLKVVTDPID FSTLNYINKR VSIAINNFGV TGSNCCLIVS SFKGNQIRNN
460 470 480 490 500
INNKSKSPKQ YLIPFSTNSI KSLDLYKSRI DNNVEFKEFA ENQIKSKSKK
510 520 530 540 550
LIQRSVVIAS NWDEFNLKSN TINTSNDKLT SNMLVSSNKK NVTMVFVFCG
560 570 580 590 600
QGAQYSTMAK NLYDNEPIFK KSMDKIDSKL NEYYGFSILE KLRSFNENDL
610 620 630 640 650
KGIQYSIIAQ PSTCMVQISL FELYCHWGIK PSIIVGHSLG EISSSYCSGM
660 670 680 690 700
IDLDTFCYLI YHRSMVQSKT NGLGRMLSIS IGENEYNSKY SSRYPELEIA
710 720 730 740 750
CYNSPSSIVI AGKELILNEI IKELKKDGVF CAILGSPTSF HTSSQLSVKD
760 770 780 790 800
EILKISFKSK QPTIPIFSTV TTNLYDEMNP FDTKYVYDNI INPVRFTNTI
810 820 830 840 850
SNIYKHIELN YSVNNNSNEV IFIEIAPHPT LSFYLKQMVP EDKKQSVSIF
860 870 880 890 900
SPLSKKKSND LFEIQKLISE LYCLGYNGIG FNIQLSDHNN TNNQTRVNLP
910 920 930 940 950
LYQWEDQEYW KLDNLHQYHL SNGPSINHLG ISNSNHTPIK SYQTHINIQK
960 970 980 990 1000
KPFQWLKGHQ IKGKYYFPGC GYIDNILKIF GESKTDTNPN KELPDILISF
1010 1020 1030 1040 1050
IEFKTPLIFM DGISQCLQTN IHSTGKKEYK ALFHFKDEKS SSDWVQTSTA
1060 1070 1080 1090 1100
NFQLFSRGPN LNEDDEQSLF MYNINDLISN QCNLTKLSKQ ELYSHIKTKC
1110 1120 1130 1140 1150
GLNYSGDFQR VDKCYLGYNC SLSEISIIQG VNENRSTFFD SSIIDCCLHG
1160 1170 1180 1190 1200
SIGLIDENCQ LVFEKLEELT YYSSKVPKTT SQHSKIYVYS KLKPRIGDSY
1210 1220 1230 1240 1250
SASIIVMLEN GTVLFEMENA SFKSTTKIKD PLAMEYPTNE IYSCNLQSKD
1260 1270 1280 1290 1300
SLIPSLSSFD HIFKRKIPNE YVDQINIYES FIPKLLFSNI NKRCPEITID
1310 1320 1330 1340 1350
EIQSSEIEQL LLKYYKIKED NDNKWLSRLF TFAFESIKQW YHNEDYDFEN
1360 1370 1380 1390 1400
VLSPHNFKIF SKSTKIISKL LFPLENDNDE DSPQSLFEGG LLDKFYSSGF
1410 1420 1430 1440 1450
SAQNELVGEI IQESIKPILN EKLVFRILEF GGGVGSLSLL VLEKINSLLI
1460 1470 1480 1490 1500
QYPNYQIDIE YTWSDISPSF ITEAKAKFEK FNDRFNIIYK ALNLEQPLIG
1510 1520 1530 1540 1550
EKQGLKPQYF DYIIMFNVLH VIKDVKYGVE QIYQLLVPNG HLLFIEPIYK
1560 1570 1580 1590 1600
SIIGDGIFGV FDQWWSFQDT EIRKDRCCMK QKTWYKLLKS VNFNDDIRMT
1610 1620 1630 1640 1650
PELTCFVIQA QKPSISNLSF SKSETTNYDS IIVFGNKYAS NLSNHFIKSI
1660 1670 1680 1690 1700
DNGNLQFIST IEELNKIGKY ISNESIIYFI KSIDELSVDN FVNITHEYTQ
1710 1720 1730 1740 1750
INQKLMELNC KCKHVLITND STTTNYLSSS LIGAARYYHE CPLELFILNF
1760 1770 1780 1790 1800
DTPSIIENQN LFKTIEPLIN SSINIQREFI INNHKVYYER IKNETKLKSI
1810 1820 1830 1840 1850
FKNSSSFESL EQVDNFMISL TPNLEYKVKV KPTSILKENE VEIKVMSTGL
1860 1870 1880 1890 1900
NYKDYLIYAG LVESVEPIFG IEFSGIITRI STGSKEFKVG DHVYGIGKST
1910 1920 1930 1940 1950
TSSHIITDID VISHKPSNIS HSEASSIPVV YLTSYHSLYN IGALKNNETI
1960 1970 1980 1990 2000
LIHSATGGVG LSTLEILKWK GHSGLIFVTV GSNEKEEYLR ENYGDMISGI
2010 2020 2030 2040 2050
YSTRNKNFVK QIKSKISKLN PFGKSGVDFI LNTLSSSDYM DSNFKCLNMS
2060 2070 2080 2090 2100
GRIVDLSITH LNSNEFTDNK KFKYNYGYHN IELQYVDKKI IKSTLSIISN
2110 2120 2130 2140 2150
AVSSNDLQLI PITHYSIEKV KESIEFINER VHMGKIIINH ENQDSIINEL
2160 2170 2180 2190 2200
IEKQKSINKF DQSIFKQNYK LEPSLLGRNI LLTGQSGIVL EILKWILRNS
2210 2220 2230 2240 2250
ENNSIGNIII LSKSSIKWEM EYLINKVKLI NKLGNFFNNI KFHFKSVDIS
2260 2270 2280 2290 2300
DSGLIDESIN KLLIENPDIN NIDSIFHFAY TQATCNSDEV DLHHLTQSHS
2310 2320 2330 2340 2350
AKSMGAINLH NQSIKRNWKL KNFIMSSSVS SKTSTANQCG YISSNNVLDA
2360 2370 2380 2390 2400
LSKYRISIGL PTICTNYGLI ESTGFVSRNE SVAALLSGEG FIPISANLIL
2410 2420 2430 2440 2450
GTLDLQLQNQ AQSSNLILSN FNFTSLNGLP QKSLISKFDY QININEENEK
2460 2470 2480 2490 2500
SKSLLKDDNV ELTVDQLITF KISEILSTDI LKLNKDIILV DYGIDSLVII
2510 2520 2530 2540
QLKNWVDKEF SIPNELTIQK IQNSTINSFI QLVKNSMDKN KK
Length:2,542
Mass (Da):288,536
Last modified:May 24, 2005 - v1
Checksum:iD281219899617A16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA. Translation: EAL61826.1.
RefSeqiXP_635304.1. XM_630212.1.

Genome annotation databases

EnsemblProtistsiEAL61826; EAL61826; DDB_G0291684.
GeneIDi8628248.
KEGGiddi:DDB_G0291684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000177 Genomic DNA. Translation: EAL61826.1.
RefSeqiXP_635304.1. XM_630212.1.

3D structure databases

ProteinModelPortaliQ54ED6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0235301.

Proteomic databases

PaxDbiQ54ED6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL61826; EAL61826; DDB_G0291684.
GeneIDi8628248.
KEGGiddi:DDB_G0291684.

Organism-specific databases

dictyBaseiDDB_G0291684. pks41.

Phylogenomic databases

eggNOGiKOG1202. Eukaryota.
COG3321. LUCA.
InParanoidiQ54ED6.
OMAiRIEANDT.
PhylomeDBiQ54ED6.

Enzyme and pathway databases

ReactomeiR-DDI-163765. ChREBP activates metabolic gene expression.
R-DDI-199220. Vitamin B5 (pantothenate) metabolism.
R-DDI-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

PROiQ54ED6.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.150. 1 hit.
3.40.50.720. 2 hits.
3.90.180.10. 1 hit.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR013217. Methyltransf_12.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR009081. PP-bd_ACP.
IPR029063. SAM-dependent_MTases.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF16197. KAsynt_C_assoc. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 1 hit.
PF14765. PS-DH. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00825. PKS_KS. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 2 hits.
SSF52151. SSF52151. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF53901. SSF53901. 1 hit.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKS41_DICDI
AccessioniPrimary (citable) accession number: Q54ED6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of polyketide synthase genes and clustered as a pair pks40/pks41 in chromosome 6.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.