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Q54E41

- HAOX_DICDI

UniProt

Q54E41 - HAOX_DICDI

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Protein

Hydroxyacid oxidase

Gene

haox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has 2-hydroxyacid oxidase activity.By similarity

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMN.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521SubstratePROSITE-ProRule annotation
Binding sitei134 – 1341FMNPROSITE-ProRule annotation
Binding sitei156 – 1561FMNPROSITE-ProRule annotation
Binding sitei158 – 1581SubstratePROSITE-ProRule annotation
Binding sitei184 – 1841FMNPROSITE-ProRule annotation
Binding sitei193 – 1931SubstratePROSITE-ProRule annotation
Binding sitei255 – 2551FMNPROSITE-ProRule annotation
Active sitei279 – 2791Proton acceptorPROSITE-ProRule annotation
Binding sitei282 – 2821SubstratePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi310 – 33425FMNPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
  3. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
  4. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

ReactomeiREACT_211304. Glyoxylate metabolism.
UniPathwayiUPA00864; UER00830.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacid oxidase (EC:1.1.3.15)
Short name:
HAOX
Alternative name(s):
Glycolate oxidase
Short name:
GOX
Gene namesi
Name:haox
ORF Names:DDB_G0291814
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0291814. hao.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Hydroxyacid oxidasePRO_0000328260Add
BLAST

Proteomic databases

PRIDEiQ54E41.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0184082.

Structurei

3D structure databases

ProteinModelPortaliQ54E41.
SMRiQ54E41. Positions 31-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 384359FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 104Poly-Asn

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
Contains 1 FMN hydroxy acid dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1304.
InParanoidiQ54E41.
KOiK11517.
OMAiVSNIDMT.
PhylomeDBiQ54E41.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54E41-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENQFKNNNN SSSIETSNQF SNKKTNRLDS FVSVSELHEE AKRLLPKMAY
60 70 80 90 100
DYYASGSNDQ ITLAENENAF SRIKLVPRSL VDVSKVNTKT RIFGRDISTP
110 120 130 140 150
ILIAPWAMQR MASQRGELDT VEASKEFNTI MTLSSLSTTS VEDLSSATNG
160 170 180 190 200
NPGWFQLYVF KDRKVSEELV KRAESIGYSA LVLTVDTPFL GKRTADFKNS
210 220 230 240 250
FKLPNGLSLK IFEKLMLSNL DGGLNQYIAT MIDPSLTWND LKWLKSITKL
260 270 280 290 300
PILVKGIMCP KDAELALQYG ADGIIVSNHG GRQLDTCPST IEVLPYISKV
310 320 330 340 350
VRGRVPLILD GGIRRGTDVL KALAFGANAV CIGRPIIWGL STGGKDGVLK
360 370 380
VLNLLNSELQ LAMALTGITN ISDINNSIIW DQNKYIKL
Length:388
Mass (Da):42,877
Last modified:May 24, 2005 - v1
Checksum:iC42C59FFE992395D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000185 Genomic DNA. Translation: EAL61528.1.
RefSeqiXP_629946.1. XM_629944.1.

Genome annotation databases

EnsemblProtistsiDDB0267054; DDB0267054; DDB_G0291814.
GeneIDi8628352.
KEGGiddi:DDB_G0291814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000185 Genomic DNA. Translation: EAL61528.1 .
RefSeqi XP_629946.1. XM_629944.1.

3D structure databases

ProteinModelPortali Q54E41.
SMRi Q54E41. Positions 31-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0184082.

Proteomic databases

PRIDEi Q54E41.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0267054 ; DDB0267054 ; DDB_G0291814 .
GeneIDi 8628352.
KEGGi ddi:DDB_G0291814.

Organism-specific databases

dictyBasei DDB_G0291814. hao.

Phylogenomic databases

eggNOGi COG1304.
InParanoidi Q54E41.
KOi K11517.
OMAi VSNIDMT.
PhylomeDBi Q54E41.

Enzyme and pathway databases

UniPathwayi UPA00864 ; UER00830 .
Reactomei REACT_211304. Glyoxylate metabolism.

Miscellaneous databases

PROi Q54E41.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiHAOX_DICDI
AccessioniPrimary (citable) accession number: Q54E41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3