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Q54E41

- HAOX_DICDI

UniProt

Q54E41 - HAOX_DICDI

Protein

Hydroxyacid oxidase

Gene

haox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Has 2-hydroxyacid oxidase activity.By similarity

    Catalytic activityi

    (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

    Cofactori

    FMN.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521SubstratePROSITE-ProRule annotation
    Binding sitei134 – 1341FMNPROSITE-ProRule annotation
    Binding sitei156 – 1561FMNPROSITE-ProRule annotation
    Binding sitei158 – 1581SubstratePROSITE-ProRule annotation
    Binding sitei184 – 1841FMNPROSITE-ProRule annotation
    Binding sitei193 – 1931SubstratePROSITE-ProRule annotation
    Binding sitei255 – 2551FMNPROSITE-ProRule annotation
    Active sitei279 – 2791Proton acceptorPROSITE-ProRule annotation
    Binding sitei282 – 2821SubstratePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi310 – 33425FMNPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
    3. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
    4. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    ReactomeiREACT_211304. Glyoxylate metabolism.
    UniPathwayiUPA00864; UER00830.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyacid oxidase (EC:1.1.3.15)
    Short name:
    HAOX
    Alternative name(s):
    Glycolate oxidase
    Short name:
    GOX
    Gene namesi
    Name:haox
    ORF Names:DDB_G0291814
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0291814. hao.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Hydroxyacid oxidasePRO_0000328260Add
    BLAST

    Proteomic databases

    PRIDEiQ54E41.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0184082.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54E41.
    SMRiQ54E41. Positions 31-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 384359FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 104Poly-Asn

    Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
    Contains 1 FMN hydroxy acid dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1304.
    KOiK11517.
    OMAiVSNIDMT.
    PhylomeDBiQ54E41.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    [Graphical view]
    PfamiPF01070. FMN_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54E41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENQFKNNNN SSSIETSNQF SNKKTNRLDS FVSVSELHEE AKRLLPKMAY    50
    DYYASGSNDQ ITLAENENAF SRIKLVPRSL VDVSKVNTKT RIFGRDISTP 100
    ILIAPWAMQR MASQRGELDT VEASKEFNTI MTLSSLSTTS VEDLSSATNG 150
    NPGWFQLYVF KDRKVSEELV KRAESIGYSA LVLTVDTPFL GKRTADFKNS 200
    FKLPNGLSLK IFEKLMLSNL DGGLNQYIAT MIDPSLTWND LKWLKSITKL 250
    PILVKGIMCP KDAELALQYG ADGIIVSNHG GRQLDTCPST IEVLPYISKV 300
    VRGRVPLILD GGIRRGTDVL KALAFGANAV CIGRPIIWGL STGGKDGVLK 350
    VLNLLNSELQ LAMALTGITN ISDINNSIIW DQNKYIKL 388
    Length:388
    Mass (Da):42,877
    Last modified:May 24, 2005 - v1
    Checksum:iC42C59FFE992395D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000185 Genomic DNA. Translation: EAL61528.1.
    RefSeqiXP_629946.1. XM_629944.1.

    Genome annotation databases

    EnsemblProtistsiDDB0267054; DDB0267054; DDB_G0291814.
    GeneIDi8628352.
    KEGGiddi:DDB_G0291814.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000185 Genomic DNA. Translation: EAL61528.1 .
    RefSeqi XP_629946.1. XM_629944.1.

    3D structure databases

    ProteinModelPortali Q54E41.
    SMRi Q54E41. Positions 31-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0184082.

    Proteomic databases

    PRIDEi Q54E41.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0267054 ; DDB0267054 ; DDB_G0291814 .
    GeneIDi 8628352.
    KEGGi ddi:DDB_G0291814.

    Organism-specific databases

    dictyBasei DDB_G0291814. hao.

    Phylogenomic databases

    eggNOGi COG1304.
    KOi K11517.
    OMAi VSNIDMT.
    PhylomeDBi Q54E41.

    Enzyme and pathway databases

    UniPathwayi UPA00864 ; UER00830 .
    Reactomei REACT_211304. Glyoxylate metabolism.

    Miscellaneous databases

    PROi Q54E41.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    [Graphical view ]
    Pfami PF01070. FMN_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiHAOX_DICDI
    AccessioniPrimary (citable) accession number: Q54E41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3