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Q54E41 (HAOX_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyacid oxidase

Short name=HAOX
EC=1.1.3.15
Alternative name(s):
Glycolate oxidase
Short name=GOX
Gene names
Name:haox
ORF Names:DDB_G0291814
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has 2-hydroxyacid oxidase activity By similarity.

Catalytic activity

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactor

FMN By similarity.

Pathway

Organic acid metabolism; glycolate degradation; 3-phospho-D-glycerate from glycolate: step 1/4.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Hydroxyacid oxidase
PRO_0000328260

Regions

Domain26 – 384359FMN hydroxy acid dehydrogenase
Nucleotide binding310 – 33425FMN By similarity
Compositional bias7 – 104Poly-Asn

Sites

Active site2791Proton acceptor By similarity
Binding site521Substrate Potential
Binding site1341FMN By similarity
Binding site1561FMN By similarity
Binding site1581Substrate By similarity
Binding site1841FMN By similarity
Binding site1931Substrate By similarity
Binding site2551FMN By similarity
Binding site2821Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
Q54E41 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: C42C59FFE992395D

FASTA38842,877
        10         20         30         40         50         60 
MENQFKNNNN SSSIETSNQF SNKKTNRLDS FVSVSELHEE AKRLLPKMAY DYYASGSNDQ 

        70         80         90        100        110        120 
ITLAENENAF SRIKLVPRSL VDVSKVNTKT RIFGRDISTP ILIAPWAMQR MASQRGELDT 

       130        140        150        160        170        180 
VEASKEFNTI MTLSSLSTTS VEDLSSATNG NPGWFQLYVF KDRKVSEELV KRAESIGYSA 

       190        200        210        220        230        240 
LVLTVDTPFL GKRTADFKNS FKLPNGLSLK IFEKLMLSNL DGGLNQYIAT MIDPSLTWND 

       250        260        270        280        290        300 
LKWLKSITKL PILVKGIMCP KDAELALQYG ADGIIVSNHG GRQLDTCPST IEVLPYISKV 

       310        320        330        340        350        360 
VRGRVPLILD GGIRRGTDVL KALAFGANAV CIGRPIIWGL STGGKDGVLK VLNLLNSELQ 

       370        380 
LAMALTGITN ISDINNSIIW DQNKYIKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000185 Genomic DNA. Translation: EAL61528.1.

3D structure databases

ProteinModelPortalQ54E41.
SMRQ54E41. Positions 31-381.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0184082.

Proteomic databases

PRIDEQ54E41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0267054; DDB0267054; DDB_G0291814.
KEGGddi:DDB_G0291814.

Organism-specific databases

dictyBaseDDB_G0291814. hao.

Phylogenomic databases

eggNOGCOG1304.
KOK11517.
OMAIDPSINW.
PhylomeDBQ54E41.
ProtClustDBCLSZ2429507.

Enzyme and pathway databases

UniPathwayUPA00864; UER00830.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ54E41.

Entry information

Entry nameHAOX_DICDI
AccessionPrimary (citable) accession number: Q54E41
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase