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Q54DU9

- TP4AA_DICDI

UniProt

Q54DU9 - TP4AA_DICDI

Protein

Probable protein tyrosine phosphatase type IVA A

Gene

DDB_G0292024

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751Proton donorBy similarity
    Active sitei107 – 1071Phosphocysteine intermediateBy similarity
    Binding sitei113 – 1131SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein tyrosine phosphatase type IVA A (EC:3.1.3.48)
    Gene namesi
    ORF Names:DDB_G0292024
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0292024.

    Subcellular locationi

    Membrane Curated; Lipid-anchor Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Probable protein tyrosine phosphatase type IVA APRO_0000329025Add
    BLAST
    Propeptidei164 – 1663Removed in mature formBy similarityPRO_0000396656

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 107By similarity
    Modified residuei163 – 1631Cysteine methyl esterBy similarity
    Lipidationi163 – 1631S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PRIDEiQ54DU9.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0184168.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54DU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 15167Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni108 – 1136Phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG265664.
    KOiK18041.
    OMAiKAKFCDD.
    PhylomeDBiQ54DU9.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54DU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGIRSALPN PASLVESSTH RFLIFDAPND DNLPLYINEL KKYNVSHLVR    50
    ACDPTYSTEP LQAIGIQVHD MPFADGGSPP DAVVNNWIKI LGESYKKDSK 100
    ETIGIHCVAG LGRAPVLVAI ALIEGGMNPL QAVEYIRERR RGSINIKQIQ 150
    YLKNYKSKKK SSCRIM 166
    Length:166
    Mass (Da):18,422
    Last modified:May 24, 2005 - v1
    Checksum:iB9A1CE094E6AB73D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000187 Genomic DNA. Translation: EAL61368.1.
    RefSeqiXP_629773.1. XM_629771.1.

    Genome annotation databases

    EnsemblProtistsiDDB0238561; DDB0238561; DDB_G0292024.
    GeneIDi8628449.
    KEGGiddi:DDB_G0292024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000187 Genomic DNA. Translation: EAL61368.1 .
    RefSeqi XP_629773.1. XM_629771.1.

    3D structure databases

    ProteinModelPortali Q54DU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0184168.

    Proteomic databases

    PRIDEi Q54DU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0238561 ; DDB0238561 ; DDB_G0292024 .
    GeneIDi 8628449.
    KEGGi ddi:DDB_G0292024.

    Organism-specific databases

    dictyBasei DDB_G0292024.

    Phylogenomic databases

    eggNOGi NOG265664.
    KOi K18041.
    OMAi KAKFCDD.
    PhylomeDBi Q54DU9.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiTP4AA_DICDI
    AccessioniPrimary (citable) accession number: Q54DU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3