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Protein

Protoporphyrinogen oxidase

Gene

ppox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.By similarity

Catalytic activityi

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FADBy similarity
Nucleotide bindingi42 – 432FADBy similarity
Nucleotide bindingi70 – 734FADBy similarity
Nucleotide bindingi511 – 5133FADBy similarity

GO - Molecular functioni

  1. oxygen-dependent protoporphyrinogen oxidase activity Source: dictyBase

GO - Biological processi

  1. cell motility Source: dictyBase
  2. heme biosynthetic process Source: dictyBase
  3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00251; UER00324.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoporphyrinogen oxidase (EC:1.3.3.4)
Short name:
PPO
Gene namesi
Name:ppox
Synonyms:hemG
ORF Names:DDB_G0292040
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292040. hemG.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Protoporphyrinogen oxidasePRO_0000327793Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231419.

Structurei

3D structure databases

ProteinModelPortaliQ54DT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi397 – 41014Poly-AsnAdd
BLAST

Sequence similaritiesi

Belongs to the protoporphyrinogen oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1232.
InParanoidiQ54DT8.
KOiK00231.
OMAiEHLENTI.
PhylomeDBiQ54DT8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.660.20. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR016040. NAD(P)-bd_dom.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54DT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQKVGIIGS GISGLSSYYY LRNGINLTSK FSKNNLKINI FEKSNKVGGN
60 70 80 90 100
IQTRIIQGKN KDEKIIVEEG PRSLRALGRG LNTLEFIKRL GISNDIIFSS
110 120 130 140 150
ANSNGKFVLL DGKPKEIPMT SLFDIIKFSF KHSIVSSILK EPFKKVPSQV
160 170 180 190 200
KEMDPNWDES VHDFFSRRLG KTMTKTFIEP TILGIYGGDY TNLSIKSTFK
210 220 230 240 250
RAALLEPFGG LILGSLFKSK KQKQFELDLD KNEKRLLPSK NELTELFDKD
260 270 280 290 300
TDKTNVFSFK ENGLSRMIQK LKSLIESDSL TKLYLSTSIV EIEKDVTNGT
310 320 330 340 350
LKVTDNKGNQ YQYDQLISTI PLNQLAPMFK KSDSKLYQLL QSVNYTSIAV
360 370 380 390 400
INLIYKSNKN VVKIISDKGF GYLVPSKENQ SVIGVCFDSN TFPEFVNNNN
410 420 430 440 450
NNNNDNDNGN EKDQSIITVM IGGNNGIKDR NDNWIDVTNT SKDKLLDIAL
460 470 480 490 500
KHLDKVLDIE SSPDFTNVSI YDNGIPHYNI GHQNLINEIQ NHITKNYGTT
510 520 530
LLLGGNSIDG VGINDSIHKS KQLINSLKLS NN
Length:532
Mass (Da):59,681
Last modified:May 24, 2005 - v1
Checksum:iEBB0066495A696A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000187 Genomic DNA. Translation: EAL61376.1.
RefSeqiXP_629784.1. XM_629782.1.

Genome annotation databases

EnsemblProtistsiDDB0231419; DDB0231419; DDB_G0292040.
GeneIDi8628461.
KEGGiddi:DDB_G0292040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000187 Genomic DNA. Translation: EAL61376.1.
RefSeqiXP_629784.1. XM_629782.1.

3D structure databases

ProteinModelPortaliQ54DT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0231419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231419; DDB0231419; DDB_G0292040.
GeneIDi8628461.
KEGGiddi:DDB_G0292040.

Organism-specific databases

dictyBaseiDDB_G0292040. hemG.

Phylogenomic databases

eggNOGiCOG1232.
InParanoidiQ54DT8.
KOiK00231.
OMAiEHLENTI.
PhylomeDBiQ54DT8.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00324.

Miscellaneous databases

PROiQ54DT8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.660.20. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR016040. NAD(P)-bd_dom.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPPOX_DICDI
AccessioniPrimary (citable) accession number: Q54DT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.