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Q54DT8 (PPOX_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoporphyrinogen oxidase

Short name=PPO
EC=1.3.3.4
Gene names
Name:ppox
Synonyms:hemG
ORF Names:DDB_G0292040
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX By similarity.

Catalytic activity

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactor

Binds 1 FAD per subunit By similarity.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the protoporphyrinogen oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Protoporphyrinogen oxidase
PRO_0000327793

Regions

Nucleotide binding9 – 146FAD By similarity
Nucleotide binding42 – 432FAD By similarity
Nucleotide binding70 – 734FAD By similarity
Nucleotide binding511 – 5133FAD By similarity
Compositional bias397 – 41014Poly-Asn

Sequences

Sequence LengthMass (Da)Tools
Q54DT8 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: EBB0066495A696A7

FASTA53259,681
        10         20         30         40         50         60 
MIQKVGIIGS GISGLSSYYY LRNGINLTSK FSKNNLKINI FEKSNKVGGN IQTRIIQGKN 

        70         80         90        100        110        120 
KDEKIIVEEG PRSLRALGRG LNTLEFIKRL GISNDIIFSS ANSNGKFVLL DGKPKEIPMT 

       130        140        150        160        170        180 
SLFDIIKFSF KHSIVSSILK EPFKKVPSQV KEMDPNWDES VHDFFSRRLG KTMTKTFIEP 

       190        200        210        220        230        240 
TILGIYGGDY TNLSIKSTFK RAALLEPFGG LILGSLFKSK KQKQFELDLD KNEKRLLPSK 

       250        260        270        280        290        300 
NELTELFDKD TDKTNVFSFK ENGLSRMIQK LKSLIESDSL TKLYLSTSIV EIEKDVTNGT 

       310        320        330        340        350        360 
LKVTDNKGNQ YQYDQLISTI PLNQLAPMFK KSDSKLYQLL QSVNYTSIAV INLIYKSNKN 

       370        380        390        400        410        420 
VVKIISDKGF GYLVPSKENQ SVIGVCFDSN TFPEFVNNNN NNNNDNDNGN EKDQSIITVM 

       430        440        450        460        470        480 
IGGNNGIKDR NDNWIDVTNT SKDKLLDIAL KHLDKVLDIE SSPDFTNVSI YDNGIPHYNI 

       490        500        510        520        530 
GHQNLINEIQ NHITKNYGTT LLLGGNSIDG VGINDSIHKS KQLINSLKLS NN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000187 Genomic DNA. Translation: EAL61376.1.

3D structure databases

ProteinModelPortalQ54DT8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231419.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231419; DDB0231419; DDB_G0292040.
KEGGddi:DDB_G0292040.

Organism-specific databases

dictyBaseDDB_G0292040. hemG.

Phylogenomic databases

eggNOGCOG1232.
KOK00231.
OMASTINTHS.
PhylomeDBQ54DT8.

Enzyme and pathway databases

UniPathwayUPA00251; UER00324.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.660.20. 1 hit.
InterProIPR002937. Amino_oxidase.
IPR016040. NAD(P)-bd_dom.
IPR004572. Protoporphyrinogen_oxidase.
IPR027418. Protoporphyrinogen_oxidase_C.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00562. proto_IX_ox. 1 hit.
ProtoNetSearch...

Other

PROQ54DT8.

Entry information

Entry namePPOX_DICDI
AccessionPrimary (citable) accession number: Q54DT8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase