Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q54DT8

- PPOX_DICDI

UniProt

Q54DT8 - PPOX_DICDI

Protein

Protoporphyrinogen oxidase

Gene

ppox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.By similarity

    Catalytic activityi

    Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146FADBy similarity
    Nucleotide bindingi42 – 432FADBy similarity
    Nucleotide bindingi70 – 734FADBy similarity
    Nucleotide bindingi511 – 5133FADBy similarity

    GO - Molecular functioni

    1. oxygen-dependent protoporphyrinogen oxidase activity Source: dictyBase

    GO - Biological processi

    1. cellular component movement Source: dictyBase
    2. heme biosynthetic process Source: dictyBase
    3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    ReactomeiREACT_204058. Heme biosynthesis.
    UniPathwayiUPA00251; UER00324.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoporphyrinogen oxidase (EC:1.3.3.4)
    Short name:
    PPO
    Gene namesi
    Name:ppox
    Synonyms:hemG
    ORF Names:DDB_G0292040
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0292040. hemG.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Protoporphyrinogen oxidasePRO_0000327793Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231419.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54DT8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi397 – 41014Poly-AsnAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protoporphyrinogen oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1232.
    KOiK00231.
    OMAiGTVAKNE.
    PhylomeDBiQ54DT8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.660.20. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR016040. NAD(P)-bd_dom.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54DT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQKVGIIGS GISGLSSYYY LRNGINLTSK FSKNNLKINI FEKSNKVGGN    50
    IQTRIIQGKN KDEKIIVEEG PRSLRALGRG LNTLEFIKRL GISNDIIFSS 100
    ANSNGKFVLL DGKPKEIPMT SLFDIIKFSF KHSIVSSILK EPFKKVPSQV 150
    KEMDPNWDES VHDFFSRRLG KTMTKTFIEP TILGIYGGDY TNLSIKSTFK 200
    RAALLEPFGG LILGSLFKSK KQKQFELDLD KNEKRLLPSK NELTELFDKD 250
    TDKTNVFSFK ENGLSRMIQK LKSLIESDSL TKLYLSTSIV EIEKDVTNGT 300
    LKVTDNKGNQ YQYDQLISTI PLNQLAPMFK KSDSKLYQLL QSVNYTSIAV 350
    INLIYKSNKN VVKIISDKGF GYLVPSKENQ SVIGVCFDSN TFPEFVNNNN 400
    NNNNDNDNGN EKDQSIITVM IGGNNGIKDR NDNWIDVTNT SKDKLLDIAL 450
    KHLDKVLDIE SSPDFTNVSI YDNGIPHYNI GHQNLINEIQ NHITKNYGTT 500
    LLLGGNSIDG VGINDSIHKS KQLINSLKLS NN 532
    Length:532
    Mass (Da):59,681
    Last modified:May 24, 2005 - v1
    Checksum:iEBB0066495A696A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000187 Genomic DNA. Translation: EAL61376.1.
    RefSeqiXP_629784.1. XM_629782.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231419; DDB0231419; DDB_G0292040.
    GeneIDi8628461.
    KEGGiddi:DDB_G0292040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000187 Genomic DNA. Translation: EAL61376.1 .
    RefSeqi XP_629784.1. XM_629782.1.

    3D structure databases

    ProteinModelPortali Q54DT8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231419.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231419 ; DDB0231419 ; DDB_G0292040 .
    GeneIDi 8628461.
    KEGGi ddi:DDB_G0292040.

    Organism-specific databases

    dictyBasei DDB_G0292040. hemG.

    Phylogenomic databases

    eggNOGi COG1232.
    KOi K00231.
    OMAi GTVAKNE.
    PhylomeDBi Q54DT8.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00324 .
    Reactomei REACT_204058. Heme biosynthesis.

    Miscellaneous databases

    PROi Q54DT8.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.660.20. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR016040. NAD(P)-bd_dom.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPPOX_DICDI
    AccessioniPrimary (citable) accession number: Q54DT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3