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Q54DT8

- PPOX_DICDI

UniProt

Q54DT8 - PPOX_DICDI

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Protein

Protoporphyrinogen oxidase

Gene

ppox

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.By similarity

Catalytic activityi

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactori

Binds 1 FAD per subunit.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FADBy similarity
Nucleotide bindingi42 – 432FADBy similarity
Nucleotide bindingi70 – 734FADBy similarity
Nucleotide bindingi511 – 5133FADBy similarity

GO - Molecular functioni

  1. oxygen-dependent protoporphyrinogen oxidase activity Source: dictyBase

GO - Biological processi

  1. cellular component movement Source: dictyBase
  2. heme biosynthetic process Source: dictyBase
  3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_204058. Heme biosynthesis.
UniPathwayiUPA00251; UER00324.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoporphyrinogen oxidase (EC:1.3.3.4)
Short name:
PPO
Gene namesi
Name:ppox
Synonyms:hemG
ORF Names:DDB_G0292040
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292040. hemG.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Protoporphyrinogen oxidasePRO_0000327793Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231419.

Structurei

3D structure databases

ProteinModelPortaliQ54DT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi397 – 41014Poly-AsnAdd
BLAST

Sequence similaritiesi

Belongs to the protoporphyrinogen oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1232.
InParanoidiQ54DT8.
KOiK00231.
OMAiGTVAKNE.
PhylomeDBiQ54DT8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.660.20. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR016040. NAD(P)-bd_dom.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54DT8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQKVGIIGS GISGLSSYYY LRNGINLTSK FSKNNLKINI FEKSNKVGGN
60 70 80 90 100
IQTRIIQGKN KDEKIIVEEG PRSLRALGRG LNTLEFIKRL GISNDIIFSS
110 120 130 140 150
ANSNGKFVLL DGKPKEIPMT SLFDIIKFSF KHSIVSSILK EPFKKVPSQV
160 170 180 190 200
KEMDPNWDES VHDFFSRRLG KTMTKTFIEP TILGIYGGDY TNLSIKSTFK
210 220 230 240 250
RAALLEPFGG LILGSLFKSK KQKQFELDLD KNEKRLLPSK NELTELFDKD
260 270 280 290 300
TDKTNVFSFK ENGLSRMIQK LKSLIESDSL TKLYLSTSIV EIEKDVTNGT
310 320 330 340 350
LKVTDNKGNQ YQYDQLISTI PLNQLAPMFK KSDSKLYQLL QSVNYTSIAV
360 370 380 390 400
INLIYKSNKN VVKIISDKGF GYLVPSKENQ SVIGVCFDSN TFPEFVNNNN
410 420 430 440 450
NNNNDNDNGN EKDQSIITVM IGGNNGIKDR NDNWIDVTNT SKDKLLDIAL
460 470 480 490 500
KHLDKVLDIE SSPDFTNVSI YDNGIPHYNI GHQNLINEIQ NHITKNYGTT
510 520 530
LLLGGNSIDG VGINDSIHKS KQLINSLKLS NN
Length:532
Mass (Da):59,681
Last modified:May 24, 2005 - v1
Checksum:iEBB0066495A696A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000187 Genomic DNA. Translation: EAL61376.1.
RefSeqiXP_629784.1. XM_629782.1.

Genome annotation databases

EnsemblProtistsiDDB0231419; DDB0231419; DDB_G0292040.
GeneIDi8628461.
KEGGiddi:DDB_G0292040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000187 Genomic DNA. Translation: EAL61376.1 .
RefSeqi XP_629784.1. XM_629782.1.

3D structure databases

ProteinModelPortali Q54DT8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231419 ; DDB0231419 ; DDB_G0292040 .
GeneIDi 8628461.
KEGGi ddi:DDB_G0292040.

Organism-specific databases

dictyBasei DDB_G0292040. hemG.

Phylogenomic databases

eggNOGi COG1232.
InParanoidi Q54DT8.
KOi K00231.
OMAi GTVAKNE.
PhylomeDBi Q54DT8.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00324 .
Reactomei REACT_204058. Heme biosynthesis.

Miscellaneous databases

PROi Q54DT8.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.660.20. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR016040. NAD(P)-bd_dom.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPPOX_DICDI
AccessioniPrimary (citable) accession number: Q54DT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3