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Protein

Squalene synthase

Gene

fdfT

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Mg2+By similarity

Pathwayi: lanosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Squalene synthase (fdfT)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandMagnesium, NADP

Enzyme and pathway databases

ReactomeiR-DDI-191273 Cholesterol biosynthesis
UniPathwayiUPA00767; UER00751

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene namesi
Name:fdfT
ORF Names:DDB_G0292072
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292072 fdfT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei285 – 304HelicalSequence analysisAdd BLAST20
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276031 – 416Squalene synthaseAdd BLAST416

Proteomic databases

PaxDbiQ54DR1

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231376

Structurei

3D structure databases

ProteinModelPortaliQ54DR1
SMRiQ54DR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1459 Eukaryota
COG1562 LUCA
InParanoidiQ54DR1
KOiK00801
OMAiFNFVAIP
PhylomeDBiQ54DR1

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR002060 Squ/phyt_synthse
IPR006449 Squal_synth-like
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR01559 squal_synth, 1 hit
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q54DR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYMKSLAHP DEFLSLLKIG YTESFKPKSQ LKENLGNKEW CYELLNKTSR
60 70 80 90 100
SFAFVINELE PSLKDAICIF YLVLRGLDTI EDDTTVELNT KLPVLTSFSE
110 120 130 140 150
GLYQPGYKVF GYGMNNDEKN LVENFDKVVD VFLGLGDGYC TIIHDITRRM
160 170 180 190 200
ANGMSEFLQK SVVTLPEWDL YCHYVAGLVG IGLSKIFHAS GLESEWFATA
210 220 230 240 250
DDESNQMGLF LQKTNIIRDY LEDINEKRIF WPRDVWARYT LHLENFKEAK
260 270 280 290 300
YQIPALHCLN DLITNALSHA LIALDYMSRL KNPQVINFCA IPQVMAIGTL
310 320 330 340 350
NACYNNYNVF TGVVKIRKGQ RALIVDAIQS KGLTATYELF FKFANEMRHK
360 370 380 390 400
VPPNDPSAKK TIQHLESIEK LCIEKLGYRP SGFNDFISYD WMAVTSLAVS
410
SAFLIARHGP NFFSKL
Length:416
Mass (Da):47,504
Last modified:May 24, 2005 - v1
Checksum:i02CDC89C06D3DD20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000187 Genomic DNA Translation: EAL61392.1
RefSeqiXP_629811.1, XM_629809.1

Genome annotation databases

EnsemblProtistsiEAL61392; EAL61392; DDB_G0292072
GeneIDi8628492
KEGGiddi:DDB_G0292072

Similar proteinsi

Entry informationi

Entry nameiFDFT_DICDI
AccessioniPrimary (citable) accession number: Q54DR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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