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Protein

Proteasome subunit alpha type-2

Gene

psmA2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: dictyBase
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-DDI-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DDI-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DDI-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DDI-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DDI-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DDI-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-DDI-382556. ABC-family proteins mediated transport.
R-DDI-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DDI-5632684. Hedgehog 'on' state.
R-DDI-5658442. Regulation of RAS by GAPs.
R-DDI-5689603. UCH proteinases.
R-DDI-5689880. Ub-specific processing proteases.
R-DDI-6798695. Neutrophil degranulation.
R-DDI-68949. Orc1 removal from chromatin.
R-DDI-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DDI-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DDI-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DDI-8948751. Regulation of PTEN stability and activity.
R-DDI-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-2 (EC:3.4.25.1)
Gene namesi
Name:psmA2
ORF Names:DDB_G0292122
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292122. psmA2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: dictyBase
  • proteasome core complex, alpha-subunit complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003284851 – 232Proteasome subunit alpha type-2Add BLAST232

Proteomic databases

PaxDbiQ54DM7.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0232935.

Structurei

3D structure databases

ProteinModelPortaliQ54DM7.
SMRiQ54DM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0181. Eukaryota.
ENOG410XPQ8. LUCA.
InParanoidiQ54DM7.
KOiK02726.
OMAiSGAYFGW.
PhylomeDBiQ54DM7.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
IPR034644. Proteasome_subunit_alpha2.
PANTHERiPTHR11599:SF16. PTHR11599:SF16. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54DM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDYSFSLT TFSPSGKLVQ IEHALQAAAS GGSAIGIKAK NGVVLITEKK
60 70 80 90 100
LHSLVDVTSV QKISMITENI GLVYAGMGPD SRVLIKKARK ESEKYYKQYK
110 120 130 140 150
EKIPVLQLVR ELASIMQEFT QSGGVRPFGV SLLVAGFDEK GPHLYQVDPS
160 170 180 190 200
GSYFAWKATA IGKNMVSSKT FLEKRYSDDL EIEDAIQTAL ITIKEGFETQ
210 220 230
LTEFNMELAI IGKNQEFKIL TPAQIKDYLL NL
Length:232
Mass (Da):25,666
Last modified:May 24, 2005 - v1
Checksum:iE0F1EFDA41191095
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000187 Genomic DNA. Translation: EAL61417.1.
RefSeqiXP_629845.1. XM_629843.1.

Genome annotation databases

EnsemblProtistsiEAL61417; EAL61417; DDB_G0292122.
GeneIDi8628525.
KEGGiddi:DDB_G0292122.

Similar proteinsi

Entry informationi

Entry nameiPSA2_DICDI
AccessioniPrimary (citable) accession number: Q54DM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families