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Protein

Proteasome subunit alpha type-2

Gene

psmA2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_274720. Orc1 removal from chromatin.
REACT_295029. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_297739. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_297926. Hedgehog 'on' state.
REACT_314379. ER-Phagosome pathway.
REACT_317678. APC/C:Cdc20 mediated degradation of Securin.
REACT_319046. Separation of Sister Chromatids.
REACT_324488. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_336966. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_344410. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_350432. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_351052. Autodegradation of Cdh1 by Cdh1:APC/C.

Protein family/group databases

MEROPSiT01.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-2 (EC:3.4.25.1)
Gene namesi
Name:psmA2
ORF Names:DDB_G0292122
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292122. psmA2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: dictyBase
  • proteasome core complex Source: GO_Central
  • proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Proteasome subunit alpha type-2PRO_0000328485Add
BLAST

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0232935.

Structurei

3D structure databases

ProteinModelPortaliQ54DM7.
SMRiQ54DM7. Positions 5-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
InParanoidiQ54DM7.
KOiK02726.
OMAiWKATALG.
PhylomeDBiQ54DM7.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54DM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDYSFSLT TFSPSGKLVQ IEHALQAAAS GGSAIGIKAK NGVVLITEKK
60 70 80 90 100
LHSLVDVTSV QKISMITENI GLVYAGMGPD SRVLIKKARK ESEKYYKQYK
110 120 130 140 150
EKIPVLQLVR ELASIMQEFT QSGGVRPFGV SLLVAGFDEK GPHLYQVDPS
160 170 180 190 200
GSYFAWKATA IGKNMVSSKT FLEKRYSDDL EIEDAIQTAL ITIKEGFETQ
210 220 230
LTEFNMELAI IGKNQEFKIL TPAQIKDYLL NL
Length:232
Mass (Da):25,666
Last modified:May 24, 2005 - v1
Checksum:iE0F1EFDA41191095
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000187 Genomic DNA. Translation: EAL61417.1.
RefSeqiXP_629845.1. XM_629843.1.

Genome annotation databases

EnsemblProtistsiDDB0232935; DDB0232935; DDB_G0292122.
GeneIDi8628525.
KEGGiddi:DDB_G0292122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000187 Genomic DNA. Translation: EAL61417.1.
RefSeqiXP_629845.1. XM_629843.1.

3D structure databases

ProteinModelPortaliQ54DM7.
SMRiQ54DM7. Positions 5-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0232935.

Protein family/group databases

MEROPSiT01.972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0232935; DDB0232935; DDB_G0292122.
GeneIDi8628525.
KEGGiddi:DDB_G0292122.

Organism-specific databases

dictyBaseiDDB_G0292122. psmA2.

Phylogenomic databases

eggNOGiCOG0638.
InParanoidiQ54DM7.
KOiK02726.
OMAiWKATALG.
PhylomeDBiQ54DM7.

Enzyme and pathway databases

ReactomeiREACT_274720. Orc1 removal from chromatin.
REACT_295029. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_297739. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_297926. Hedgehog 'on' state.
REACT_314379. ER-Phagosome pathway.
REACT_317678. APC/C:Cdc20 mediated degradation of Securin.
REACT_319046. Separation of Sister Chromatids.
REACT_324488. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_336966. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_344410. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_350432. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_351052. Autodegradation of Cdh1 by Cdh1:APC/C.

Miscellaneous databases

PROiQ54DM7.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPSA2_DICDI
AccessioniPrimary (citable) accession number: Q54DM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 27, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.