ID   ALDH3_DICDI             Reviewed;         470 AA.
AC   Q54DG1; Q86MX3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Aldehyde dehydrogenase family 3 comG;
DE            EC=1.2.1.5;
DE   AltName: Full=Communication mutant protein G;
GN   Name=comG; ORFNames=DDB_G0292270;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 269-347.
RX   PubMed=12871696; DOI=10.1016/S0012-1606(03)00204-5;
RA   Kibler K., Nguyen T.-L., Svetz J., Van Driessche N., Ibarra M.,
RA   Thompson C., Shaw C., Shaulsky G.;
RT   "A novel developmental mechanism in Dictyostelium revealed in a screen
RT   for communication mutants.";
RL   Dev. Biol. 259:193-208(2003).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(P)(+) + H(2)O = an acid +
CC       NAD(P)H.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAFI02000189; EAL61259.1; -; Genomic_DNA.
DR   EMBL; AY221644; AAO34400.1; -; Genomic_DNA.
DR   RefSeq; XP_629680.1; -.
DR   GeneID; 3386347; -.
DR   KEGG; ddi:DDB_0185188; -.
DR   dictyBase; DDB_G0292270; comG.
DR   OMA; Q54DG1; ITELLEY.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:EC.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   PANTHER; PTHR11699:SF15; ALDH; 1.
DR   Pfam; PF00171; Aldedh; 3.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; NAD; Oxidoreductase.
FT   CHAIN         1    470       Aldehyde dehydrogenase family 3 comG.
FT                                /FTId=PRO_0000342179.
FT   NP_BIND     196    201       NAD (By similarity).
FT   ACT_SITE    218    218       By similarity.
FT   ACT_SITE    252    252       By similarity.
SQ   SEQUENCE   470 AA;  52563 MW;  26F49BE34D31A205 CRC64;
     MSTSAAATLP LSVISKNLRK VFLSQKTRKI DWRYSQLKAI KKMMSENKDN ITAAVKKDLG
     KHEFEIHQTE IVMIQTELDE TISHLESWNK TEKVYSPLHF KPASSYILKE PLGVVLIMSP
     WNYPVNLALI PLIGAIAGGN CALLKLSRHS YNISKLLHGL LTKYLDPECF EFDCEGGAPY
     ITELLEYKWD HIFFTGSVKV GKIVYQAAAK FLTPVTLELG GKNPCIVDKD TDIKLTARRL
     IWGKCWNAGQ TCIGLDYLIV HKSILEPLIE EFKVVLKEFF GEDIKKSTSF ARIISSAAAE
     RLQQLFSMGK VVIGGEADIA ERYIAPTVIV DPDLDSPLMQ DEIFGPVLPI VTYENIDECL
     EFIQNRPHAL TLYLFSRDQA IQDKVLDGTQ SGSLMINDTL LHFTNPNLPF GGIGDSGIGS
     YHGKGTFDIF VHKRGLVQST TKKFLDLPLR YPPYTPFSDN VAGKILGSGW
//