Q54DG1 (ALDH3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldehyde dehydrogenase family 3 comG
EC=1.2.1.5

Alternative name(s):
Communication mutant protein G

Gene names

Name:	comG
ORF Names:	DDB_G0292270

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from sequence or structural similarity. Source: dictyBase cellular aldehyde metabolic process Inferred from sequence or structural similarity. Source: dictyBase sorocarp development Inferred from mutant phenotype Ref.2. Source: dictyBase
Cellular component	cytosol Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	3-chloroallyl aldehyde dehydrogenase activity Inferred from sequence or structural similarity Ref.2. Source: dictyBase aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Aldehyde dehydrogenase family 3 comG		PRO_0000342179
Regions
	Nucleotide binding	196 – 201	6	NAD By similarity
Sites
	Active site	218	1	By similarity
	Active site	252	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54DG1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 26F49BE34D31A205	FASTA	470	52,563
	10 20 30 40 50 60 MSTSAAATLP LSVISKNLRK VFLSQKTRKI DWRYSQLKAI KKMMSENKDN ITAAVKKDLG 70 80 90 100 110 120 KHEFEIHQTE IVMIQTELDE TISHLESWNK TEKVYSPLHF KPASSYILKE PLGVVLIMSP 130 140 150 160 170 180 WNYPVNLALI PLIGAIAGGN CALLKLSRHS YNISKLLHGL LTKYLDPECF EFDCEGGAPY 190 200 210 220 230 240 ITELLEYKWD HIFFTGSVKV GKIVYQAAAK FLTPVTLELG GKNPCIVDKD TDIKLTARRL 250 260 270 280 290 300 IWGKCWNAGQ TCIGLDYLIV HKSILEPLIE EFKVVLKEFF GEDIKKSTSF ARIISSAAAE 310 320 330 340 350 360 RLQQLFSMGK VVIGGEADIA ERYIAPTVIV DPDLDSPLMQ DEIFGPVLPI VTYENIDECL 370 380 390 400 410 420 EFIQNRPHAL TLYLFSRDQA IQDKVLDGTQ SGSLMINDTL LHFTNPNLPF GGIGDSGIGS 430 440 450 460 470 YHGKGTFDIF VHKRGLVQST TKKFLDLPLR YPPYTPFSDN VAGKILGSGW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"A novel developmental mechanism in Dictyostelium revealed in a screen for communication mutants." Kibler K., Nguyen T.-L., Svetz J., Van Driessche N., Ibarra M., Thompson C., Shaw C., Shaulsky G. Dev. Biol. 259:193-208(2003) [PubMed: 12871696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 269-347.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000189 Genomic DNA. Translation: EAL61259.1. AY221644 Genomic DNA. Translation: AAO34400.1.
RefSeq	XP_629680.1. XM_629678.1.
3D structure databases
HSSP	HSSP built from PDB template 1AD3 based on UniProtKB P11883.
ProteinModelPortal	Q54DG1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54DG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0185188; DDB0185188; DDB_G0292270.
GeneID	8628596.
GenomeReviews	Gene locus comG in contig CM000155_GR.
KEGG	ddi:DDB_G0292270.
Organism-specific databases
dictyBase	DDB_G0292270. comG.
Phylogenomic databases
eggNOG	KOG2456.
GeneTree	EPrGT00050000005093.
HOGENOM	HBG752218.
OMA	DFESEVS.
PhylomeDB	Q54DG1.
ProtClustDB	PTZ00381.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR012394. Aldehyde_DH_NAD(P). [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699:SF15. ALDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH3_DICDI

Accession

Primary (citable) accession number: Q54DG1
Secondary accession number(s): Q86MX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	May 24, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)