Reviewed,
UniProtKB/Swiss-Prot Q54DD3 (GCST_DICDI)
Last modified
February 9, 2010.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aminomethyltransferase, mitochondrial EC=2.1.2.10 Alternative name(s): Glycine cleavage system T protein Short name=GCVT | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 403 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | The glycine cleavage system catalyzes the degradation of glycine By similarity. |
| Catalytic activity | [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. |
| Subunit structure | The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. |
| Subcellular location | Mitochondrion By similarity. |
| Sequence similarities | Belongs to the gcvT family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Molecular function | Aminotransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glycine catabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000189 Genomic DNA. Translation: EAL61287.1. |
| RefSeq | XP_629708.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1WSR based on UniProtKB P48728. |
| SMR | Q54DD3. Positions 24-403. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q54DD3. |
Genome annotation databases | |
| GeneID | 8628622. |
| KEGG | ddi:DDB_0231218. |
Organism-specific databases | |
| dictyBase | DDB_G0292326. gcvT. |
Phylogenomic databases | |
| eggNOG | KOG2770. |
| HOGENOM | HBG299834. |
| OMA | YSLYGSD. |
| PhylomeDB | Q54DD3. |
Enzyme and pathway databases | |
| BRENDA | 2.1.2.10. 424. |
Family and domain databases | |
| InterPro | IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view] |
| Pfam | PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF006487. GcvT. 1 hit. |
| TIGRFAMs | TIGR00528. gcvT. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GCST_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q54DD3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

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