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Q54D75

- Y2550_DICDI

UniProt

Q54D75 - Y2550_DICDI

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Protein

Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550

Gene
DDB_G0292550
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei124 – 1241Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_223567. RNA Polymerase II Pre-transcription Events.
REACT_224777. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550 (EC:2.7.11.22)
Gene namesi
ORF Names:DDB_G0292550
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13971397Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550PRO_0000362047Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0229424.

Structurei

3D structure databases

ProteinModelPortaliQ54D75.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 287284Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi319 – 3257Poly-Asn
Compositional biasi410 – 42213Poly-AsnAdd
BLAST
Compositional biasi426 – 46035Poly-AsnAdd
BLAST
Compositional biasi463 – 47311Poly-AsnAdd
BLAST
Compositional biasi476 – 4838Poly-Asn
Compositional biasi487 – 52640Poly-AsnAdd
BLAST
Compositional biasi546 – 5505Poly-Asn
Compositional biasi553 – 56816Poly-AsnAdd
BLAST
Compositional biasi649 – 6557Poly-Gln
Compositional biasi688 – 71023Poly-AsnAdd
BLAST
Compositional biasi730 – 7356Poly-Asn
Compositional biasi739 – 75113Poly-AsnAdd
BLAST
Compositional biasi767 – 79933Poly-AsnAdd
BLAST
Compositional biasi830 – 8334Poly-Asn
Compositional biasi844 – 85512Poly-AsnAdd
BLAST
Compositional biasi863 – 8697Poly-Thr
Compositional biasi872 – 92150Poly-AsnAdd
BLAST
Compositional biasi924 – 94017Poly-AsnAdd
BLAST
Compositional biasi1012 – 10176Poly-Asn
Compositional biasi1031 – 109161Poly-AsnAdd
BLAST
Compositional biasi1123 – 113311Poly-AsnAdd
BLAST
Compositional biasi1136 – 114914Poly-AsnAdd
BLAST
Compositional biasi1180 – 11878Poly-Ser
Compositional biasi1193 – 11986Poly-Ser
Compositional biasi1201 – 12066Poly-Ser
Compositional biasi1253 – 132068Poly-AsnAdd
BLAST
Compositional biasi1340 – 13434Poly-Lys
Compositional biasi1357 – 138024Gln-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ54D75.
OMAiNNINANH.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54D75-1 [UniParc]FASTAAdd to Basket

« Hide

MNSFQIIELI GSGSYGKVYK AIHNLSKCTV ALKIISVMNI ENGLPVEVKY     50
LMKLRDCKNI VHLIEYFYSN DDKLVMVFEY LEYDLWKFIS PKNKYMTLSC 100
TKFFIHQLLE GLDELHSQKI MHLDIKPSNL LINPRFDLKI ADFGFTTYIG 150
NPHLAHQVIS LFYRPPELLM GSRNYGPEVD IWSVGCIIVE MLTGFYMFAG 200
SNDSLQLELI FKTFGTPTEK NWPGISKLSG YSPYLGSKSK KYPSKSLKDI 250
SKFKSFSNST LDIILRMLTL CPKNRISTKE ALNHPWFFED PIASPPLDDI 300
INCLVSRPVK ISKQHQKTNN CNNNNGSYDI IPPNSILVPK RSSSQQAALQ 350
TQQVVDVDLQ YLILKAEQQQ IQYQKLVLQT SVPNHIYKEV YEVNQLLKQY 400
ILRLKQQKVN LNNNNLNNNN NNLYGNNNHN NNNNNNNNNN NNNNNNNYNN 450
NNNNHNNNYN HDNNNNNNYN NNNYKNNNNS NNNFSFNNSN NNNNNNNNNN 500
RNNRNNNNNN NNNNNNNNYN NNSNNNSYNN NFNNGFNNND NINDDNNNNN 550
SYNNVNNNNI NNNNNNNNGF NGFNNYGNNF NNSNNNGNQF GANNNSFNNT 600
DFSNDSNYGS YCNGLMDLIN NNSMYNGGNY YMNNASFHQR IQEHIQKIQQ 650
QQLQQMEDQQ QEKLNFRDYH PLSIPSQHHN TSSSDTHNNN NNNYNNNNNN 700
NNNINNNNIN SIHNQSSDHN HFIPNNGFTN ENNNNHCINN MNNSNNNNNN 750
NIGNIGSNGG SINEMGNNNN NNNNNNNNNN NNNNNNNNIN ANHNRNNNNG 800
SNDFSDFNGN QMVINSYNNN SNNNGNINGN NNNGNGNING IIGNNNNNNS 850
NNNNNTSFNG NRTTTTTTTS SNFNNINNNN NNSNNNNKNN NNKNNNNNNN 900
NNNNNNNNNN NNNNNNNSNN NSINNNTNNN NNNNNNNNGN GLTSSYANHF 950
QYNHPPFNIS NAPHPIPFLN NQSIPNSNYQ FLNRFSFSNY SNNNSNGLAN 1000
NYQNPFGHGA TNSNNNNSGN NDHVFGHNTF NFNQNNNNNN NNNNNNNNNN 1050
NNNNNNNSNN NSNNNNYNSN NNDNSNSNSN NNNNNNNNNN NSLFNNFNTH 1100
NNSINRGNNS FDSFNNGFNH LKNNNNNINN NNNDINNNNN NNNNNNNNNG 1150
ITKNNTQFGP NILSSTQTSH NSPVSLTPIS VSSSSFSNYS PTSFSSSSME 1200
SLSSSSEFLS SESLSFTNSN QFSPLLNSAS QDINNNSRSS RHRSKLNIDT 1250
KGNNNNNNNN KNNNNNNNNN NNNNNNNNNN NNNSNNINND NNNNSNNNSN 1300
SNNNNSNSNN NNNSNNNNNN SFGLKRYVDD NEEQLLANQK KKKNIKSSPL 1350
PSASSSQQSQ TQQQHQIQQQ SQTQQQSQTQ KIENNDGLSV ENPIVLD 1397
Length:1,397
Mass (Da):158,111
Last modified:May 24, 2005 - v1
Checksum:i2604DAB60C955BCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000190 Genomic DNA. Translation: EAL61254.1.
RefSeqiXP_629621.1. XM_629619.1.

Genome annotation databases

EnsemblProtistsiDDB0229424; DDB0229424; DDB_G0292550.
GeneIDi8628684.
KEGGiddi:DDB_G0292550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000190 Genomic DNA. Translation: EAL61254.1 .
RefSeqi XP_629621.1. XM_629619.1.

3D structure databases

ProteinModelPortali Q54D75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0229424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0229424 ; DDB0229424 ; DDB_G0292550 .
GeneIDi 8628684.
KEGGi ddi:DDB_G0292550.

Organism-specific databases

dictyBasei DDB_G0292550.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q54D75.
OMAi NNINANH.

Enzyme and pathway databases

Reactomei REACT_223567. RNA Polymerase II Pre-transcription Events.
REACT_224777. RNA Polymerase II Transcription Elongation.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiY2550_DICDI
AccessioniPrimary (citable) accession number: Q54D75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3