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Q54D75

- Y2550_DICDI

UniProt

Q54D75 - Y2550_DICDI

Protein

Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550

Gene

DDB_G0292550

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei124 – 1241Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_223567. RNA Polymerase II Pre-transcription Events.
    REACT_224777. RNA Polymerase II Transcription Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550 (EC:2.7.11.22)
    Gene namesi
    ORF Names:DDB_G0292550
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0292550.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13971397Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550PRO_0000362047Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0229424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54D75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 287284Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi319 – 3257Poly-Asn
    Compositional biasi410 – 42213Poly-AsnAdd
    BLAST
    Compositional biasi426 – 46035Poly-AsnAdd
    BLAST
    Compositional biasi463 – 47311Poly-AsnAdd
    BLAST
    Compositional biasi476 – 4838Poly-Asn
    Compositional biasi487 – 52640Poly-AsnAdd
    BLAST
    Compositional biasi546 – 5505Poly-Asn
    Compositional biasi553 – 56816Poly-AsnAdd
    BLAST
    Compositional biasi649 – 6557Poly-Gln
    Compositional biasi688 – 71023Poly-AsnAdd
    BLAST
    Compositional biasi730 – 7356Poly-Asn
    Compositional biasi739 – 75113Poly-AsnAdd
    BLAST
    Compositional biasi767 – 79933Poly-AsnAdd
    BLAST
    Compositional biasi830 – 8334Poly-Asn
    Compositional biasi844 – 85512Poly-AsnAdd
    BLAST
    Compositional biasi863 – 8697Poly-Thr
    Compositional biasi872 – 92150Poly-AsnAdd
    BLAST
    Compositional biasi924 – 94017Poly-AsnAdd
    BLAST
    Compositional biasi1012 – 10176Poly-Asn
    Compositional biasi1031 – 109161Poly-AsnAdd
    BLAST
    Compositional biasi1123 – 113311Poly-AsnAdd
    BLAST
    Compositional biasi1136 – 114914Poly-AsnAdd
    BLAST
    Compositional biasi1180 – 11878Poly-Ser
    Compositional biasi1193 – 11986Poly-Ser
    Compositional biasi1201 – 12066Poly-Ser
    Compositional biasi1253 – 132068Poly-AsnAdd
    BLAST
    Compositional biasi1340 – 13434Poly-Lys
    Compositional biasi1357 – 138024Gln-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    InParanoidiQ54D75.
    OMAiNNINANH.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54D75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSFQIIELI GSGSYGKVYK AIHNLSKCTV ALKIISVMNI ENGLPVEVKY     50
    LMKLRDCKNI VHLIEYFYSN DDKLVMVFEY LEYDLWKFIS PKNKYMTLSC 100
    TKFFIHQLLE GLDELHSQKI MHLDIKPSNL LINPRFDLKI ADFGFTTYIG 150
    NPHLAHQVIS LFYRPPELLM GSRNYGPEVD IWSVGCIIVE MLTGFYMFAG 200
    SNDSLQLELI FKTFGTPTEK NWPGISKLSG YSPYLGSKSK KYPSKSLKDI 250
    SKFKSFSNST LDIILRMLTL CPKNRISTKE ALNHPWFFED PIASPPLDDI 300
    INCLVSRPVK ISKQHQKTNN CNNNNGSYDI IPPNSILVPK RSSSQQAALQ 350
    TQQVVDVDLQ YLILKAEQQQ IQYQKLVLQT SVPNHIYKEV YEVNQLLKQY 400
    ILRLKQQKVN LNNNNLNNNN NNLYGNNNHN NNNNNNNNNN NNNNNNNYNN 450
    NNNNHNNNYN HDNNNNNNYN NNNYKNNNNS NNNFSFNNSN NNNNNNNNNN 500
    RNNRNNNNNN NNNNNNNNYN NNSNNNSYNN NFNNGFNNND NINDDNNNNN 550
    SYNNVNNNNI NNNNNNNNGF NGFNNYGNNF NNSNNNGNQF GANNNSFNNT 600
    DFSNDSNYGS YCNGLMDLIN NNSMYNGGNY YMNNASFHQR IQEHIQKIQQ 650
    QQLQQMEDQQ QEKLNFRDYH PLSIPSQHHN TSSSDTHNNN NNNYNNNNNN 700
    NNNINNNNIN SIHNQSSDHN HFIPNNGFTN ENNNNHCINN MNNSNNNNNN 750
    NIGNIGSNGG SINEMGNNNN NNNNNNNNNN NNNNNNNNIN ANHNRNNNNG 800
    SNDFSDFNGN QMVINSYNNN SNNNGNINGN NNNGNGNING IIGNNNNNNS 850
    NNNNNTSFNG NRTTTTTTTS SNFNNINNNN NNSNNNNKNN NNKNNNNNNN 900
    NNNNNNNNNN NNNNNNNSNN NSINNNTNNN NNNNNNNNGN GLTSSYANHF 950
    QYNHPPFNIS NAPHPIPFLN NQSIPNSNYQ FLNRFSFSNY SNNNSNGLAN 1000
    NYQNPFGHGA TNSNNNNSGN NDHVFGHNTF NFNQNNNNNN NNNNNNNNNN 1050
    NNNNNNNSNN NSNNNNYNSN NNDNSNSNSN NNNNNNNNNN NSLFNNFNTH 1100
    NNSINRGNNS FDSFNNGFNH LKNNNNNINN NNNDINNNNN NNNNNNNNNG 1150
    ITKNNTQFGP NILSSTQTSH NSPVSLTPIS VSSSSFSNYS PTSFSSSSME 1200
    SLSSSSEFLS SESLSFTNSN QFSPLLNSAS QDINNNSRSS RHRSKLNIDT 1250
    KGNNNNNNNN KNNNNNNNNN NNNNNNNNNN NNNSNNINND NNNNSNNNSN 1300
    SNNNNSNSNN NNNSNNNNNN SFGLKRYVDD NEEQLLANQK KKKNIKSSPL 1350
    PSASSSQQSQ TQQQHQIQQQ SQTQQQSQTQ KIENNDGLSV ENPIVLD 1397
    Length:1,397
    Mass (Da):158,111
    Last modified:May 24, 2005 - v1
    Checksum:i2604DAB60C955BCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000190 Genomic DNA. Translation: EAL61254.1.
    RefSeqiXP_629621.1. XM_629619.1.

    Genome annotation databases

    EnsemblProtistsiDDB0229424; DDB0229424; DDB_G0292550.
    GeneIDi8628684.
    KEGGiddi:DDB_G0292550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000190 Genomic DNA. Translation: EAL61254.1 .
    RefSeqi XP_629621.1. XM_629619.1.

    3D structure databases

    ProteinModelPortali Q54D75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0229424.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0229424 ; DDB0229424 ; DDB_G0292550 .
    GeneIDi 8628684.
    KEGGi ddi:DDB_G0292550.

    Organism-specific databases

    dictyBasei DDB_G0292550.

    Phylogenomic databases

    eggNOGi COG0515.
    InParanoidi Q54D75.
    OMAi NNINANH.

    Enzyme and pathway databases

    Reactomei REACT_223567. RNA Polymerase II Pre-transcription Events.
    REACT_224777. RNA Polymerase II Transcription Elongation.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiY2550_DICDI
    AccessioniPrimary (citable) accession number: Q54D75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3