Q54D07 (CY1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c1, heme protein, mitochondrial
Short name=Cytochrome c-1

Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4

Gene names

Name:	cyc1
ORF Names:	DDB_G0292594

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain By similarity.
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side By similarity.
Sequence similarities	Belongs to the cytochrome c family. Contains 1 cytochrome c domain.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from sequence or structural similarity. Source: dictyBase respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 28	28	Mitochondrion Potential
	Chain	29 – 275	247	Cytochrome c1, heme protein, mitochondrial		PRO_0000328027
Regions
	Transmembrane	240 – 258	19	Helical; Note=Anchors to the membrane; Potential
	Domain	60 – 212	153	Cytochrome c
Sites
	Metal binding	77	1	Iron (heme axial ligand) By similarity
	Binding site	73	1	Heme (covalent) By similarity
	Binding site	76	1	Heme (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54D07 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: FAE2AC89D86CC1AA	FASTA	275	30,536
	10 20 30 40 50 60 MFSQKLLANG KLLSKLAIVS GVVGTATAIT TSTTLLSDDF VQPTSYPWEH RFPWQSYDHA 70 80 90 100 110 120 AIRRGHQVYT QVCSTCHSLN LISYRHLANV AYTPEELKAM AADTTVMDGP DSEGDMFERK 130 140 150 160 170 180 GQVTDFHPKP YPNSNAARFA NNGALPPDLS LVIKARGAHE DYVFSLLTGY CEPPAGVRVV 190 200 210 220 230 240 GGQYFNPYFP GTKIAMAPPL ADGMVEYDDG TDNSMSQMAK DVSTFLCWAS EPEHDDRKKL 250 260 270 GMKVLLGVSI IALPLFYWKR LKWSVIKTRK ISFKD

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000194 Genomic DNA. Translation: EAL61100.1.
RefSeq	XP_629513.1. XM_629511.1.
3D structure databases
ProteinModelPortal	Q54D07.
SMR	Q54D07. Positions 37-274.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDBDRAFT_0184465.
Proteomic databases
PRIDE	Q54D07.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0238603; DDB0238603; DDB_G0292594.
GeneID	8628764.
KEGG	ddi:DDB_G0292594.
Organism-specific databases
dictyBase	DDB_G0292594. cyc1.
Phylogenomic databases
eggNOG	COG2857.
KO	K00413.
OMA	EIEKRPG.
ProtClustDB	CLSZ2728718.
Family and domain databases
InterPro	IPR002326. Cyt_c1. IPR021157. Cyt_c1_TM_anchor_C. IPR009056. Cyt_c_dom. [Graphical view]
PANTHER	PTHR10266. PTHR10266. 1 hit.
Pfam	PF02167. Cytochrom_C1. 1 hit. [Graphical view]
PRINTS	PR00603. CYTOCHROMEC1.
SUPFAM	SSF81496. Cyt_c1_TM_anchor_C. 1 hit. SSF46626. Cytochrome_c. 1 hit.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CY1_DICDI

Accession

Primary (citable) accession number: Q54D07

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)