Reviewed,
UniProtKB/Swiss-Prot Q54CX6 (3HIDH_DICDI)
Last modified
February 9, 2010.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial Short name=HIBADH EC=1.1.1.31 | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 321 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH. |
| Subcellular location | Mitochondrion By similarity. |
| Sequence similarities | Belongs to the 3-hydroxyisobutyrate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shuntInferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 3-hydroxyisobutyrate dehydrogenase activity Inferred from electronic annotation. Source: EC NAD or NADH bindingInferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion By similarity | |||||||
| Chain | ? – 321 | Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial | PRO_0000327881 | ||||||
Regions | |||||||||
| Nucleotide binding | 23 – 52 | 30 | NAD By similarity | ||||||
| Nucleotide binding | 86 – 87 | 2 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 192 | 1 | By similarity | ||||||
| Binding site | 117 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 267 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000194 Genomic DNA. Translation: EAL61086.1. |
| RefSeq | XP_629544.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2GF2 based on UniProtKB P31937. |
| SMR | Q54CX6. Positions 23-315. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q54CX6. |
Genome annotation databases | |
| GeneID | 8628802. |
| KEGG | ddi:DDB_0216217. |
Organism-specific databases | |
| dictyBase | DDB_G0292566. hibA. |
Phylogenomic databases | |
| HOGENOM | HBG729179. |
| OMA | PMARNLI. |
| PhylomeDB | Q54CX6. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.31. 424. |
Family and domain databases | |
| InterPro | IPR015815. 3hydroxyacid_DH/Rdtase. IPR008927. 6-PGluconate_DH_C-like. IPR006115. 6PGDH_NAD-bd. IPR013328. DH_multihelical. IPR011548. IsoBut3OH_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| PANTHER | PTHR22981. 3hydroxy_acid_DH. 1 hit. |
| Pfam | PF03446. NAD_binding_2. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01692. HIBADH. 1 hit. |
| PROSITE | PS00895. 3_HYDROXYISOBUT_DH. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | 3HIDH_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q54CX6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


