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Q54CW7 (RTPR_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Short name=RTPR
EC=1.17.4.2
Gene names
Name:rtpR
ORF Names:DDB_G0292654
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length758 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 758758Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326544

Sites

Active site4481 By similarity
Active site4501 By similarity

Amino acid modifications

Disulfide bond194 ↔ 459Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54CW7 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 31A26E078E105F8E

FASTA75886,008
        10         20         30         40         50         60 
MLTIKRLLLN QNLFKSSCNS TGIISINYNS NNKICFFSSS STLINKTNEI LDIEDNNNNN 

        70         80         90        100        110        120 
NEISSSPLFL KETIKEFKLK KEFIEKYSKK KAPFGFGVLG EIVYRRSYSR VKEDNTNEQW 

       130        140        150        160        170        180 
FETVERVVNG TYNIQRKWIE RHGLEWNQNK AQKSAQEMYN RIFEMKFLPP GRGLYSCGSS 

       190        200        210        220        230        240 
TTESKGLFAA LNNCAFVSTL DIKKNPSKPF IFLMDASMLG VGVGFDTKGE NSIIIKGQLP 

       250        260        270        280        290        300 
PPPPQQQPQQ QQQQHGQNNN IFIVPDSREG WVESVQLLLD SYFLKRNNPI FDYSSIRKKG 

       310        320        330        340        350        360 
EPIKGFGGVC CGYEPLKELH DEIRALLNKC IGKPISSTNI VDLMNLIGKC VVSGNVRQAA 

       370        380        390        400        410        420 
EIAFGDPNSQ EYIDLKNYQI NPQRASFGWC SNNSVFAELG MDYSKVCQSI LHNGEPGLAW 

       430        440        450        460        470        480 
LDNMKAYSRM VPTELDYKDR RAMGGNPCLE QTLESYELCC LVETFPNNHE SLEDYLKTLK 

       490        500        510        520        530        540 
YAFLYAKTVT LGSTQWPDTN KVLLRNRRIG CSMSGIAQFI HFNGLHQLKD WCVNGFKLLN 

       550        560        570        580        590        600 
ELDEKYSEWL AIPKSIKRTS IKPSGTVSLL AGATPGMHYP ISEYYIRRIR IQKESNLIPP 

       610        620        630        640        650        660 
LVEAGYHVEP AFENSTNVVV EIPIHSGKGI RSANSITMWE QLSLASFLQK YWADNQVSCT 

       670        680        690        700        710        720 
VSFDPIKEGP QLKHALDYFQ YQLKGVSFLP NSSTTTSVYK QMPYEEIDET RYNQIIANLK 

       730        740        750 
PVDFQKLNNS PLEPTPDKFC DSSSCTIVSD NSETLNNL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000194 Genomic DNA. Translation: EAL61130.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0233056.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0233056; DDB0233056; DDB_G0292654.
KEGGddi:DDB_G0292654.

Organism-specific databases

dictyBaseDDB_G0292654. ndrJ.

Phylogenomic databases

eggNOGCOG1372.
OMAWISGTDY.
ProtClustDBCLSZ2429388.

Family and domain databases

InterProIPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRTPR_DICDI
AccessionPrimary (citable) accession number: Q54CW7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase