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Q54CW7

- RTPR_DICDI

UniProt

Q54CW7 - RTPR_DICDI

Protein

Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei448 – 4481By similarity
    Active sitei450 – 4501By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: dictyBase
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. nucleoside triphosphate biosynthetic process Source: dictyBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rtpR
    ORF Names:DDB_G0292654
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0292654. ndrJ.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 758758Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326544Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi194 ↔ 459Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0233056.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1372.
    OMAiDSLNNCW.

    Family and domain databases

    InterProiIPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54CW7-1 [UniParc]FASTAAdd to Basket

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    MLTIKRLLLN QNLFKSSCNS TGIISINYNS NNKICFFSSS STLINKTNEI    50
    LDIEDNNNNN NEISSSPLFL KETIKEFKLK KEFIEKYSKK KAPFGFGVLG 100
    EIVYRRSYSR VKEDNTNEQW FETVERVVNG TYNIQRKWIE RHGLEWNQNK 150
    AQKSAQEMYN RIFEMKFLPP GRGLYSCGSS TTESKGLFAA LNNCAFVSTL 200
    DIKKNPSKPF IFLMDASMLG VGVGFDTKGE NSIIIKGQLP PPPPQQQPQQ 250
    QQQQHGQNNN IFIVPDSREG WVESVQLLLD SYFLKRNNPI FDYSSIRKKG 300
    EPIKGFGGVC CGYEPLKELH DEIRALLNKC IGKPISSTNI VDLMNLIGKC 350
    VVSGNVRQAA EIAFGDPNSQ EYIDLKNYQI NPQRASFGWC SNNSVFAELG 400
    MDYSKVCQSI LHNGEPGLAW LDNMKAYSRM VPTELDYKDR RAMGGNPCLE 450
    QTLESYELCC LVETFPNNHE SLEDYLKTLK YAFLYAKTVT LGSTQWPDTN 500
    KVLLRNRRIG CSMSGIAQFI HFNGLHQLKD WCVNGFKLLN ELDEKYSEWL 550
    AIPKSIKRTS IKPSGTVSLL AGATPGMHYP ISEYYIRRIR IQKESNLIPP 600
    LVEAGYHVEP AFENSTNVVV EIPIHSGKGI RSANSITMWE QLSLASFLQK 650
    YWADNQVSCT VSFDPIKEGP QLKHALDYFQ YQLKGVSFLP NSSTTTSVYK 700
    QMPYEEIDET RYNQIIANLK PVDFQKLNNS PLEPTPDKFC DSSSCTIVSD 750
    NSETLNNL 758
    Length:758
    Mass (Da):86,008
    Last modified:May 24, 2005 - v1
    Checksum:i31A26E078E105F8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000194 Genomic DNA. Translation: EAL61130.1.
    RefSeqiXP_629553.1. XM_629551.1.

    Genome annotation databases

    EnsemblProtistsiDDB0233056; DDB0233056; DDB_G0292654.
    GeneIDi8628811.
    KEGGiddi:DDB_G0292654.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000194 Genomic DNA. Translation: EAL61130.1 .
    RefSeqi XP_629553.1. XM_629551.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0233056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233056 ; DDB0233056 ; DDB_G0292654 .
    GeneIDi 8628811.
    KEGGi ddi:DDB_G0292654.

    Organism-specific databases

    dictyBasei DDB_G0292654. ndrJ.

    Phylogenomic databases

    eggNOGi COG1372.
    OMAi DSLNNCW.

    Family and domain databases

    InterProi IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiRTPR_DICDI
    AccessioniPrimary (citable) accession number: Q54CW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3