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Q54CW7

- RTPR_DICDI

UniProt

Q54CW7 - RTPR_DICDI

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Protein

Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei448 – 4481By similarity
Active sitei450 – 4501By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: dictyBase
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. nucleoside triphosphate biosynthetic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
ORF Names:DDB_G0292654
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292654. ndrJ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi194 ↔ 459Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0233056.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
InParanoidiQ54CW7.
OMAiDSLNNCW.

Family and domain databases

InterProiIPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54CW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTIKRLLLN QNLFKSSCNS TGIISINYNS NNKICFFSSS STLINKTNEI
60 70 80 90 100
LDIEDNNNNN NEISSSPLFL KETIKEFKLK KEFIEKYSKK KAPFGFGVLG
110 120 130 140 150
EIVYRRSYSR VKEDNTNEQW FETVERVVNG TYNIQRKWIE RHGLEWNQNK
160 170 180 190 200
AQKSAQEMYN RIFEMKFLPP GRGLYSCGSS TTESKGLFAA LNNCAFVSTL
210 220 230 240 250
DIKKNPSKPF IFLMDASMLG VGVGFDTKGE NSIIIKGQLP PPPPQQQPQQ
260 270 280 290 300
QQQQHGQNNN IFIVPDSREG WVESVQLLLD SYFLKRNNPI FDYSSIRKKG
310 320 330 340 350
EPIKGFGGVC CGYEPLKELH DEIRALLNKC IGKPISSTNI VDLMNLIGKC
360 370 380 390 400
VVSGNVRQAA EIAFGDPNSQ EYIDLKNYQI NPQRASFGWC SNNSVFAELG
410 420 430 440 450
MDYSKVCQSI LHNGEPGLAW LDNMKAYSRM VPTELDYKDR RAMGGNPCLE
460 470 480 490 500
QTLESYELCC LVETFPNNHE SLEDYLKTLK YAFLYAKTVT LGSTQWPDTN
510 520 530 540 550
KVLLRNRRIG CSMSGIAQFI HFNGLHQLKD WCVNGFKLLN ELDEKYSEWL
560 570 580 590 600
AIPKSIKRTS IKPSGTVSLL AGATPGMHYP ISEYYIRRIR IQKESNLIPP
610 620 630 640 650
LVEAGYHVEP AFENSTNVVV EIPIHSGKGI RSANSITMWE QLSLASFLQK
660 670 680 690 700
YWADNQVSCT VSFDPIKEGP QLKHALDYFQ YQLKGVSFLP NSSTTTSVYK
710 720 730 740 750
QMPYEEIDET RYNQIIANLK PVDFQKLNNS PLEPTPDKFC DSSSCTIVSD

NSETLNNL
Length:758
Mass (Da):86,008
Last modified:May 24, 2005 - v1
Checksum:i31A26E078E105F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000194 Genomic DNA. Translation: EAL61130.1.
RefSeqiXP_629553.1. XM_629551.1.

Genome annotation databases

EnsemblProtistsiDDB0233056; DDB0233056; DDB_G0292654.
GeneIDi8628811.
KEGGiddi:DDB_G0292654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000194 Genomic DNA. Translation: EAL61130.1 .
RefSeqi XP_629553.1. XM_629551.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0233056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233056 ; DDB0233056 ; DDB_G0292654 .
GeneIDi 8628811.
KEGGi ddi:DDB_G0292654.

Organism-specific databases

dictyBasei DDB_G0292654. ndrJ.

Phylogenomic databases

eggNOGi COG1372.
InParanoidi Q54CW7.
OMAi DSLNNCW.

Family and domain databases

InterProi IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiRTPR_DICDI
AccessioniPrimary (citable) accession number: Q54CW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3