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Q54CW7

- RTPR_DICDI

UniProt

Q54CW7 - RTPR_DICDI

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Protein
Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
Gene
rtpR, DDB_G0292654
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei448 – 4481 By similarity
Active sitei450 – 4501 By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: dictyBase
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. nucleoside triphosphate biosynthetic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
ORF Names:DDB_G0292654
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292654. ndrJ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi194 ↔ 459Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0233056.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
OMAiDSLNNCW.

Family and domain databases

InterProiIPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54CW7-1 [UniParc]FASTAAdd to Basket

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MLTIKRLLLN QNLFKSSCNS TGIISINYNS NNKICFFSSS STLINKTNEI    50
LDIEDNNNNN NEISSSPLFL KETIKEFKLK KEFIEKYSKK KAPFGFGVLG 100
EIVYRRSYSR VKEDNTNEQW FETVERVVNG TYNIQRKWIE RHGLEWNQNK 150
AQKSAQEMYN RIFEMKFLPP GRGLYSCGSS TTESKGLFAA LNNCAFVSTL 200
DIKKNPSKPF IFLMDASMLG VGVGFDTKGE NSIIIKGQLP PPPPQQQPQQ 250
QQQQHGQNNN IFIVPDSREG WVESVQLLLD SYFLKRNNPI FDYSSIRKKG 300
EPIKGFGGVC CGYEPLKELH DEIRALLNKC IGKPISSTNI VDLMNLIGKC 350
VVSGNVRQAA EIAFGDPNSQ EYIDLKNYQI NPQRASFGWC SNNSVFAELG 400
MDYSKVCQSI LHNGEPGLAW LDNMKAYSRM VPTELDYKDR RAMGGNPCLE 450
QTLESYELCC LVETFPNNHE SLEDYLKTLK YAFLYAKTVT LGSTQWPDTN 500
KVLLRNRRIG CSMSGIAQFI HFNGLHQLKD WCVNGFKLLN ELDEKYSEWL 550
AIPKSIKRTS IKPSGTVSLL AGATPGMHYP ISEYYIRRIR IQKESNLIPP 600
LVEAGYHVEP AFENSTNVVV EIPIHSGKGI RSANSITMWE QLSLASFLQK 650
YWADNQVSCT VSFDPIKEGP QLKHALDYFQ YQLKGVSFLP NSSTTTSVYK 700
QMPYEEIDET RYNQIIANLK PVDFQKLNNS PLEPTPDKFC DSSSCTIVSD 750
NSETLNNL 758
Length:758
Mass (Da):86,008
Last modified:May 24, 2005 - v1
Checksum:i31A26E078E105F8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000194 Genomic DNA. Translation: EAL61130.1.
RefSeqiXP_629553.1. XM_629551.1.

Genome annotation databases

EnsemblProtistsiDDB0233056; DDB0233056; DDB_G0292654.
GeneIDi8628811.
KEGGiddi:DDB_G0292654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000194 Genomic DNA. Translation: EAL61130.1 .
RefSeqi XP_629553.1. XM_629551.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0233056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233056 ; DDB0233056 ; DDB_G0292654 .
GeneIDi 8628811.
KEGGi ddi:DDB_G0292654.

Organism-specific databases

dictyBasei DDB_G0292654. ndrJ.

Phylogenomic databases

eggNOGi COG1372.
OMAi DSLNNCW.

Family and domain databases

InterProi IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiRTPR_DICDI
AccessioniPrimary (citable) accession number: Q54CW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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