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Q54CM0 (PPT3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Palmitoyl-protein thioesterase 3

Short name=PPT-3
EC=3.1.2.22
Alternative name(s):
Palmitoyl-protein hydrolase 3
Gene names
Name:ppt3
ORF Names:DDB_G0292862
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation By similarity.

Catalytic activity

Palmitoyl-protein + H2O = palmitate + protein.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the palmitoyl-protein thioesterase family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processprotein modification process

Inferred from electronic annotation. Source: InterPro

   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionpalmitoyl-(protein) hydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 289269Palmitoyl-protein thioesterase 3
PRO_0000328588

Sites

Active site971 By similarity
Active site2101 By similarity
Active site2661 By similarity

Amino acid modifications

Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Glycosylation2811N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q54CM0 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 4CD378FD612CEF66

FASTA28933,050
        10         20         30         40         50         60 
MRILSSLILL IALAIALVSA TRPVVLMHGV TTGKESMEPL KSWIEESIPD IYVLNVEIGN 

        70         80         90        100        110        120 
GAFDSIFTTM DSQIEEFAQV VQADPKLANG FNLIGFSQGT LIARAFVQRY NNPQVYNYIS 

       130        140        150        160        170        180 
WNGPQGGQFG TPFVNIPWVD KVLGTIPYEK TIQKKLSVAE YWKDPHRIDK YLERSIFLAD 

       190        200        210        220        230        240 
INNEYQVKNT TYKENLTKLN AMVLTYSTND KTIIPKESGW FSFYADGSGT EVVPLQQQTQ 

       250        260        270        280 
YSEDWLGLRT LDESNRLFFY TTTCTHRDHP IEDYCKPYFT NFTLPYLQN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000197 Genomic DNA. Translation: EAL60980.1.
RefSeqXP_629396.1. XM_629394.1.

3D structure databases

HSSPHSSP built from PDB template 1EI9 based on UniProtKB P45478.
ProteinModelPortalQ54CM0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0233893; DDB0233893; DDB_G0292862.
GeneID8628914.
GenomeReviewsGene locus ppt3 in contig CM000155_GR.
KEGGddi:DDB_G0292862.

Organism-specific databases

dictyBaseDDB_G0292862. ppt3.

Phylogenomic databases

eggNOGKOG2541.
GeneTreeEPrGT00050000005467.
HOGENOMHBG444329.
OMAAEIACEN.
PhylomeDBQ54CM0.
ProtClustDBCLSZ2429345.

Family and domain databases

InterProIPR002472. Palm_thioest.
[Graphical view]
KOK01074.
PfamPF02089. Palm_thioest. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPT3_DICDI
AccessionPrimary (citable) accession number: Q54CM0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families