Reviewed, UniProtKB/Swiss-Prot Q54CJ3 (6PGL_DICDI)

Names and origin

Protein names

Recommended name:
    Probable 6-phosphogluconolactonase
      Short name=6PGL
    EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	pgls
ORF Names:	DDB_G0292898

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Probable 6-phosphogluconolactonase		PRO_0000327748

Sequences

	Sequence		Length	Mass (Da)
	Q54CJ3-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: AC9493CB9D2A787A	FASTA	236	26,824
	10 20 30 40 50 60 MTSKLINFIT IEKERFEDEC VKFIKNVITD SINSRNIATI GLSGGSTPKP IYEMLGNDSS 70 80 90 100 110 120 IDWTKVYFFA VDERYIDKSS KDSIYDLISK SVFKNRENLL VDHFITPNTS LPLKECIETY 130 140 150 160 170 180 SNDLKKLIEK SNGSPDLVTL GMGEDGHIAS IFPNSPKSPL DETDLVYHTT TERFAIFDRI 190 200 210 220 230 TTNINFLASS KNKVFFMSGS SKKKVWDEME SSQINVSRWP AHKIISSGNT NVFYRE

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000197 Genomic DNA. Translation: EAL60998.1.
RefSeq	XP_629423.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q54CJ3.
Genome annotation databases
GeneID	8628942.
KEGG	ddi:DDB_0231287.
Organism-specific databases
dictyBase	DDB_G0292898. pgl.
Phylogenomic databases
eggNOG	KOG3147.
OMA	NINFLAS.
PhylomeDB	Q54CJ3.
Enzyme and pathway databases
BRENDA	3.1.1.31. 424.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
PANTHER	PTHR11054. Phosphogluconlac. 1 hit.
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGL_DICDI

Accession

Primary (citable) accession number: Q54CJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)