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Protein

Probable 6-phosphogluconolactonase

Gene

pgl

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (g6pd-1)
  2. Probable 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-DDI-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:pgls
ORF Names:DDB_G0292898
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292898. pgl.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277481 – 236Probable 6-phosphogluconolactonaseAdd BLAST236

Proteomic databases

PaxDbiQ54CJ3.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231287.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
InParanoidiQ54CJ3.
KOiK01057.
OMAiTERFAIF.
PhylomeDBiQ54CJ3.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54CJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKLINFIT IEKERFEDEC VKFIKNVITD SINSRNIATI GLSGGSTPKP
60 70 80 90 100
IYEMLGNDSS IDWTKVYFFA VDERYIDKSS KDSIYDLISK SVFKNRENLL
110 120 130 140 150
VDHFITPNTS LPLKECIETY SNDLKKLIEK SNGSPDLVTL GMGEDGHIAS
160 170 180 190 200
IFPNSPKSPL DETDLVYHTT TERFAIFDRI TTNINFLASS KNKVFFMSGS
210 220 230
SKKKVWDEME SSQINVSRWP AHKIISSGNT NVFYRE
Length:236
Mass (Da):26,824
Last modified:May 24, 2005 - v1
Checksum:iAC9493CB9D2A787A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000197 Genomic DNA. Translation: EAL60998.1.
RefSeqiXP_629423.1. XM_629421.1.

Genome annotation databases

EnsemblProtistsiEAL60998; EAL60998; DDB_G0292898.
GeneIDi8628942.
KEGGiddi:DDB_G0292898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000197 Genomic DNA. Translation: EAL60998.1.
RefSeqiXP_629423.1. XM_629421.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231287.

Proteomic databases

PaxDbiQ54CJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL60998; EAL60998; DDB_G0292898.
GeneIDi8628942.
KEGGiddi:DDB_G0292898.

Organism-specific databases

dictyBaseiDDB_G0292898. pgl.

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
InParanoidiQ54CJ3.
KOiK01057.
OMAiTERFAIF.
PhylomeDBiQ54CJ3.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
ReactomeiR-DDI-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

PROiQ54CJ3.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_DICDI
AccessioniPrimary (citable) accession number: Q54CJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.