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Protein

Probable 6-phosphogluconolactonase

Gene

pgl

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (g6pd-1)
  2. Probable 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-DDI-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:pgls
ORF Names:DDB_G0292898
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292898 pgl

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277481 – 236Probable 6-phosphogluconolactonaseAdd BLAST236

Proteomic databases

PaxDbiQ54CJ3

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231287

Structurei

3D structure databases

SMRiQ54CJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147 Eukaryota
COG0363 LUCA
InParanoidiQ54CJ3
KOiK01057
OMAiEMEGYQY
PhylomeDBiQ54CJ3

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

Q54CJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKLINFIT IEKERFEDEC VKFIKNVITD SINSRNIATI GLSGGSTPKP
60 70 80 90 100
IYEMLGNDSS IDWTKVYFFA VDERYIDKSS KDSIYDLISK SVFKNRENLL
110 120 130 140 150
VDHFITPNTS LPLKECIETY SNDLKKLIEK SNGSPDLVTL GMGEDGHIAS
160 170 180 190 200
IFPNSPKSPL DETDLVYHTT TERFAIFDRI TTNINFLASS KNKVFFMSGS
210 220 230
SKKKVWDEME SSQINVSRWP AHKIISSGNT NVFYRE
Length:236
Mass (Da):26,824
Last modified:May 24, 2005 - v1
Checksum:iAC9493CB9D2A787A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000197 Genomic DNA Translation: EAL60998.1
RefSeqiXP_629423.1, XM_629421.1

Genome annotation databases

EnsemblProtistsiEAL60998; EAL60998; DDB_G0292898
GeneIDi8628942
KEGGiddi:DDB_G0292898

Similar proteinsi

Entry informationi

Entry namei6PGL_DICDI
AccessioniPrimary (citable) accession number: Q54CJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health