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Protein

Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Gene

pdhA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Enzyme regulationi

E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-DDI-389661 Glyoxylate metabolism and glycine degradation
R-DDI-70268 Pyruvate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-A
Gene namesi
Name:pdhA
ORF Names:DDB_G0292994
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292994 pdhA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000032798327 – 377Pyruvate dehydrogenase E1 component subunit alpha, mitochondrialAdd BLAST351

Proteomic databases

PaxDbiQ54C70
PRIDEiQ54C70

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0230193

Structurei

3D structure databases

ProteinModelPortaliQ54C70
SMRiQ54C70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0225 Eukaryota
COG1071 LUCA
InParanoidiQ54C70
KOiK00161
OMAiRRFEDKC
PhylomeDBiQ54C70

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54C70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSNFLKVNS KALGHIRTFA SKSGEIKHNF KKADTYLCDG PSDSTVTNKD
60 70 80 90 100
ELISFFTEMS RFRRLETVCD GLYKKKLIRG FCHLYTGQEA VCAGLESAIT
110 120 130 140 150
KDDHIITAYR DHTYMLSRGA TPEEIFAELL MKETGCSKGK GGSMHMFTKN
160 170 180 190 200
FYGGNGIVGA QCPLGAGIAF AQKYNKTGNV CLAMYGDGAA NQGQLFEAFN
210 220 230 240 250
MASLWKLPVI FICENNKYGM GTSQKRSTAG HDFYTRGHYV AGLKVDGMDV
260 270 280 290 300
FAVKEAGKYA AEWCRAGNGP IILEMDTYRY VGHSMSDPGI TYRTREEVNH
310 320 330 340 350
VRQTRDPIEN IRQIILDNKI ATEDQLAAIE ETVRDEMEKA SEKAIAAPLP
360 370
QARELFTNVY LQEVPVRGVE FVNSFKP
Length:377
Mass (Da):41,988
Last modified:May 24, 2005 - v1
Checksum:iBD3481894B7348C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000199 Genomic DNA Translation: EAL60849.1
RefSeqiXP_629349.1, XM_629347.1

Genome annotation databases

EnsemblProtistsiEAL60849; EAL60849; DDB_G0292994
GeneIDi8629073
KEGGiddi:DDB_G0292994

Similar proteinsi

Entry informationi

Entry nameiODPA_DICDI
AccessioniPrimary (citable) accession number: Q54C70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

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