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Q54C64

- PIGL_DICDI

UniProt

Q54C64 - PIGL_DICDI

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Protein

Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene
pigl, DDB_G0293136
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol By similarity.

Catalytic activityi

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

Pathwayi

GO - Molecular functioni

  1. N-acetylglucosaminylphosphatidylinositol deacetylase activity Source: UniProtKB-EC

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiREACT_223860. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class L protein
Short name:
PIG-L
Gene namesi
Name:pigl
ORF Names:DDB_G0293136
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293136. pigL.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylasePRO_0000328582Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0191808.

Structurei

3D structure databases

ProteinModelPortaliQ54C64.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi148 – 16720Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the PIGL family.

Phylogenomic databases

eggNOGiCOG2120.
KOiK03434.
OMAiHTQDVLF.
PhylomeDBiQ54C64.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54C64-1 [UniParc]FASTAAdd to Basket

« Hide

MKNHLNNNED NSTLIKKKVL FVIAHPDDEC MFFTPTIQHY NFIGSEIFVA    50
CLSNGNAVGL GKIREKELID SCIDMGINQE NVFFDQTNNF QDGMNIIWDT 100
DLVEKTILSF IKQTSADIVI SFDECGISSH PNHISISNGL KQLMKNKSSS 150
TTTTSTTSSS SSSSSLSNRT TNNLNKEIKA YKLETVNIIR KYIGIADIPL 200
TKLLSYDENS TQTFISTQLF PPSSYSPMTK HKSQFVWFRY LFVFLSRYSF 250
INTLIEIK 258
Length:258
Mass (Da):29,237
Last modified:May 24, 2005 - v1
Checksum:iC83B099E30F24125
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000199 Genomic DNA. Translation: EAL60920.1.
RefSeqiXP_629355.1. XM_629353.1.

Genome annotation databases

EnsemblProtistsiDDB0235227; DDB0235227; DDB_G0293136.
GeneIDi8629079.
KEGGiddi:DDB_G0293136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000199 Genomic DNA. Translation: EAL60920.1 .
RefSeqi XP_629355.1. XM_629353.1.

3D structure databases

ProteinModelPortali Q54C64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0191808.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0235227 ; DDB0235227 ; DDB_G0293136 .
GeneIDi 8629079.
KEGGi ddi:DDB_G0293136.

Organism-specific databases

dictyBasei DDB_G0293136. pigL.

Phylogenomic databases

eggNOGi COG2120.
KOi K03434.
OMAi HTQDVLF.
PhylomeDBi Q54C64.

Enzyme and pathway databases

UniPathwayi UPA00196 .
Reactomei REACT_223860. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

PROi Q54C64.

Family and domain databases

Gene3Di 3.40.50.10320. 1 hit.
InterProi IPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
[Graphical view ]
PANTHERi PTHR12993. PTHR12993. 1 hit.
Pfami PF02585. PIG-L. 1 hit.
[Graphical view ]
SUPFAMi SSF102588. SSF102588. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPIGL_DICDI
AccessioniPrimary (citable) accession number: Q54C64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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