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Q54C64

- PIGL_DICDI

UniProt

Q54C64 - PIGL_DICDI

Protein

Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

pigl

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol By similarity.By similarity

    Catalytic activityi

    6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

    Pathwayi

    GO - Molecular functioni

    1. N-acetylglucosaminylphosphatidylinositol deacetylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_223860. Synthesis of glycosylphosphatidylinositol (GPI).
    UniPathwayiUPA00196.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
    Alternative name(s):
    Phosphatidylinositol-glycan biosynthesis class L protein
    Short name:
    PIG-L
    Gene namesi
    Name:pigl
    ORF Names:DDB_G0293136
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0293136. pigL.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylasePRO_0000328582Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0191808.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54C64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi148 – 16720Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PIGL family.Curated

    Phylogenomic databases

    eggNOGiCOG2120.
    KOiK03434.
    OMAiHTQDVLF.
    PhylomeDBiQ54C64.

    Family and domain databases

    Gene3Di3.40.50.10320. 1 hit.
    InterProiIPR003737. GlcNAc_PI_deacetylase-related.
    IPR024078. LmbE-like_dom.
    [Graphical view]
    PANTHERiPTHR12993. PTHR12993. 1 hit.
    PfamiPF02585. PIG-L. 1 hit.
    [Graphical view]
    SUPFAMiSSF102588. SSF102588. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q54C64-1 [UniParc]FASTAAdd to Basket

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    MKNHLNNNED NSTLIKKKVL FVIAHPDDEC MFFTPTIQHY NFIGSEIFVA    50
    CLSNGNAVGL GKIREKELID SCIDMGINQE NVFFDQTNNF QDGMNIIWDT 100
    DLVEKTILSF IKQTSADIVI SFDECGISSH PNHISISNGL KQLMKNKSSS 150
    TTTTSTTSSS SSSSSLSNRT TNNLNKEIKA YKLETVNIIR KYIGIADIPL 200
    TKLLSYDENS TQTFISTQLF PPSSYSPMTK HKSQFVWFRY LFVFLSRYSF 250
    INTLIEIK 258
    Length:258
    Mass (Da):29,237
    Last modified:May 24, 2005 - v1
    Checksum:iC83B099E30F24125
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000199 Genomic DNA. Translation: EAL60920.1.
    RefSeqiXP_629355.1. XM_629353.1.

    Genome annotation databases

    EnsemblProtistsiDDB0235227; DDB0235227; DDB_G0293136.
    GeneIDi8629079.
    KEGGiddi:DDB_G0293136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000199 Genomic DNA. Translation: EAL60920.1 .
    RefSeqi XP_629355.1. XM_629353.1.

    3D structure databases

    ProteinModelPortali Q54C64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0191808.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0235227 ; DDB0235227 ; DDB_G0293136 .
    GeneIDi 8629079.
    KEGGi ddi:DDB_G0293136.

    Organism-specific databases

    dictyBasei DDB_G0293136. pigL.

    Phylogenomic databases

    eggNOGi COG2120.
    KOi K03434.
    OMAi HTQDVLF.
    PhylomeDBi Q54C64.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .
    Reactomei REACT_223860. Synthesis of glycosylphosphatidylinositol (GPI).

    Miscellaneous databases

    PROi Q54C64.

    Family and domain databases

    Gene3Di 3.40.50.10320. 1 hit.
    InterProi IPR003737. GlcNAc_PI_deacetylase-related.
    IPR024078. LmbE-like_dom.
    [Graphical view ]
    PANTHERi PTHR12993. PTHR12993. 1 hit.
    Pfami PF02585. PIG-L. 1 hit.
    [Graphical view ]
    SUPFAMi SSF102588. SSF102588. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPIGL_DICDI
    AccessioniPrimary (citable) accession number: Q54C64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3