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Protein

Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

pigl

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity).By similarity

Catalytic activityi

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-DDI-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class L protein
Short name:
PIG-L
Gene namesi
Name:pigl
ORF Names:DDB_G0293136
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293136 pigL

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003285821 – 258Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseAdd BLAST258

Proteomic databases

PaxDbiQ54C64

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0235227

Structurei

3D structure databases

ProteinModelPortaliQ54C64
SMRiQ54C64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi148 – 167Ser-richAdd BLAST20

Sequence similaritiesi

Belongs to the PIGL family.Curated

Phylogenomic databases

eggNOGiKOG3332 Eukaryota
COG2120 LUCA
InParanoidiQ54C64
KOiK03434
OMAiLVWFRWL
PhylomeDBiQ54C64

Family and domain databases

Gene3Di3.40.50.10320, 1 hit
InterProiView protein in InterPro
IPR003737 GlcNAc_PI_deacetylase-related
IPR024078 LmbE-like_dom_sf
PANTHERiPTHR12993 PTHR12993, 1 hit
PfamiView protein in Pfam
PF02585 PIG-L, 1 hit
SUPFAMiSSF102588 SSF102588, 1 hit

Sequencei

Sequence statusi: Complete.

Q54C64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNHLNNNED NSTLIKKKVL FVIAHPDDEC MFFTPTIQHY NFIGSEIFVA
60 70 80 90 100
CLSNGNAVGL GKIREKELID SCIDMGINQE NVFFDQTNNF QDGMNIIWDT
110 120 130 140 150
DLVEKTILSF IKQTSADIVI SFDECGISSH PNHISISNGL KQLMKNKSSS
160 170 180 190 200
TTTTSTTSSS SSSSSLSNRT TNNLNKEIKA YKLETVNIIR KYIGIADIPL
210 220 230 240 250
TKLLSYDENS TQTFISTQLF PPSSYSPMTK HKSQFVWFRY LFVFLSRYSF

INTLIEIK
Length:258
Mass (Da):29,237
Last modified:May 24, 2005 - v1
Checksum:iC83B099E30F24125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000199 Genomic DNA Translation: EAL60920.1
RefSeqiXP_629355.1, XM_629353.1

Genome annotation databases

EnsemblProtistsiEAL60920; EAL60920; DDB_G0293136
GeneIDi8629079
KEGGiddi:DDB_G0293136

Similar proteinsi

Entry informationi

Entry nameiPIGL_DICDI
AccessioniPrimary (citable) accession number: Q54C64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health