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Q54C45

- FRDA_DICDI

UniProt

Q54C45 - FRDA_DICDI

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Protein

Frataxin, mitochondrial

Gene

fxn

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+. May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

GO - Molecular functioni

  1. enzyme regulator activity Source: dictyBase
  2. ferric iron binding Source: InterPro
  3. ferrous iron binding Source: dictyBase
  4. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: dictyBase
  2. heme biosynthetic process Source: UniProtKB-KW
  3. ion transport Source: UniProtKB-KW
  4. iron incorporation into metallo-sulfur cluster Source: dictyBase
  5. regulation of catalytic activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Ion transport, Iron storage, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiREACT_208193. Mitochondrial iron-sulfur cluster biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Frataxin, mitochondrial (EC:1.16.3.1)
Short name:
Fxn
Gene namesi
Name:fxn
ORF Names:DDB_G0293246
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293246. fxn.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7272MitochondrionSequence AnalysisAdd
BLAST
Chaini73 – 193121Frataxin, mitochondrialPRO_0000328230Add
BLAST

Interactioni

Subunit structurei

Monomer. Oligomer (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0191848.

Structurei

3D structure databases

ProteinModelPortaliQ54C45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 454Poly-Asn
Compositional biasi64 – 674Poly-Gln

Sequence similaritiesi

Belongs to the frataxin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1965.
InParanoidiQ54C45.
OMAiILSEANT.
PhylomeDBiQ54C45.

Family and domain databases

Gene3Di3.30.920.10. 1 hit.
InterProiIPR017789. Frataxin.
IPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
[Graphical view]
PANTHERiPTHR16821. PTHR16821. 1 hit.
PfamiPF01491. Frataxin_Cyay. 1 hit.
[Graphical view]
SUPFAMiSSF55387. SSF55387. 1 hit.
TIGRFAMsiTIGR03421. FeS_CyaY. 1 hit.
TIGR03422. mito_frataxin. 1 hit.
PROSITEiPS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54C45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFNFLNKAS NKTHTKLLLF SSIRNRILIN NISSTSKWSS INNNNKQSSV
60 70 80 90 100
SKTNIFIITT HNKQQQQLSK SFSTINNNTK PISDVNLFHD IVDEEFELFV
110 120 130 140 150
DRLEILSEAN TCEGFEVEGN DGVLTIIVGN KGTYVINKQT PNRQIWWSSP
160 170 180 190
LSGPKRFDYD SVEKRWVDNR DGTPLRQLLN SEINTLCKYD MEI
Length:193
Mass (Da):22,206
Last modified:May 24, 2005 - v1
Checksum:i0B21618EE5DFAC71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000200 Genomic DNA. Translation: EAL60822.1.
RefSeqiXP_629221.1. XM_629219.1.

Genome annotation databases

EnsemblProtistsiDDB0266646; DDB0266646; DDB_G0293246.
GeneIDi8629103.
KEGGiddi:DDB_G0293246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000200 Genomic DNA. Translation: EAL60822.1 .
RefSeqi XP_629221.1. XM_629219.1.

3D structure databases

ProteinModelPortali Q54C45.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0191848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0266646 ; DDB0266646 ; DDB_G0293246 .
GeneIDi 8629103.
KEGGi ddi:DDB_G0293246.

Organism-specific databases

dictyBasei DDB_G0293246. fxn.

Phylogenomic databases

eggNOGi COG1965.
InParanoidi Q54C45.
OMAi ILSEANT.
PhylomeDBi Q54C45.

Enzyme and pathway databases

Reactomei REACT_208193. Mitochondrial iron-sulfur cluster biogenesis.

Family and domain databases

Gene3Di 3.30.920.10. 1 hit.
InterProi IPR017789. Frataxin.
IPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
[Graphical view ]
PANTHERi PTHR16821. PTHR16821. 1 hit.
Pfami PF01491. Frataxin_Cyay. 1 hit.
[Graphical view ]
SUPFAMi SSF55387. SSF55387. 1 hit.
TIGRFAMsi TIGR03421. FeS_CyaY. 1 hit.
TIGR03422. mito_frataxin. 1 hit.
PROSITEi PS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiFRDA_DICDI
AccessioniPrimary (citable) accession number: Q54C45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3