Q54C45 (FRDA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Frataxin, mitochondrial
Short name=Fxn
EC=1.16.3.1

Gene names

Name:	fxn
ORF Names:	DDB_G0293246

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+. May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Monomer. Oligomer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the frataxin family.

Ontologies

Keywords
Biological process	Heme biosynthesis Ion transport Iron storage Iron transport Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Iron
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from sequence or structural similarity. Source: dictyBase heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW ion transport Inferred from electronic annotation. Source: UniProtKB-KW iron incorporation into metallo-sulfur cluster Inferred from sequence or structural similarity. Source: dictyBase
Cellular_component	mitochondrion Inferred from sequence or structural similarity. Source: dictyBase
Molecular_function	enzyme regulator activity Inferred from sequence or structural similarity. Source: dictyBase ferric iron binding Inferred from electronic annotation. Source: InterPro ferrous iron binding Inferred from sequence or structural similarity. Source: dictyBase ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 72	72	Mitochondrion Potential
	Chain	73 – 193	121	Frataxin, mitochondrial		PRO_0000328230
Regions
	Compositional bias	42 – 45	4	Poly-Asn
	Compositional bias	64 – 67	4	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q54C45 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 0B21618EE5DFAC71	FASTA	193	22,206
	10 20 30 40 50 60 MIFNFLNKAS NKTHTKLLLF SSIRNRILIN NISSTSKWSS INNNNKQSSV SKTNIFIITT 70 80 90 100 110 120 HNKQQQQLSK SFSTINNNTK PISDVNLFHD IVDEEFELFV DRLEILSEAN TCEGFEVEGN 130 140 150 160 170 180 DGVLTIIVGN KGTYVINKQT PNRQIWWSSP LSGPKRFDYD SVEKRWVDNR DGTPLRQLLN 190 SEINTLCKYD MEI

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000200 Genomic DNA. Translation: EAL60822.1.
RefSeq	XP_629221.1. XM_629219.1.
3D structure databases
ProteinModelPortal	Q54C45.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDBDRAFT_0191848.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0266646; DDB0266646; DDB_G0293246.
GeneID	8629103.
KEGG	ddi:DDB_G0293246.
Organism-specific databases
dictyBase	DDB_G0293246. fxn.
Phylogenomic databases
eggNOG	COG1965.
OMA	QIWWSSP.
Family and domain databases
Gene3D	3.30.920.10. 1 hit.
InterPro	IPR017789. Frataxin. IPR002908. Frataxin/CyaY. IPR020895. Frataxin_CS. [Graphical view]
PANTHER	PTHR16821. PTHR16821. 1 hit.
Pfam	PF01491. Frataxin_Cyay. 1 hit. [Graphical view]
SUPFAM	SSF55387. Frataxin_like. 1 hit.
TIGRFAMs	TIGR03421. FeS_CyaY. 1 hit. TIGR03422. mito_frataxin. 1 hit.
PROSITE	PS01344. FRATAXIN_1. 1 hit. PS50810. FRATAXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRDA_DICDI

Accession

Primary (citable) accession number: Q54C45

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	May 29, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)